<?xml version="1.0"  encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2" version="1" level="2" xmlns:html="http://www.w3.org/1999/xhtml">
<model id="DROME_metabolic_network_metabolic_network" name="Drosophila melanogaster">
<listOfCompartments>
<compartment id="cytoplasm"/>
</listOfCompartments>
<listOfSpecies>
  <species id="GLUCURONATE" name="glucuronate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PECTIN" name="pectin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Ribonucleoside__45__Monophosphates__124__" name="a ribonucleoside monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7221" name="3-cis-dodecenoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7222" name="2-trans-dodecenoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__DIHYDROXY__45__PHENYLALANINE" name="L-dopa" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CARBON__45__MONOXIDE" name="CO" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__D__45__Amino__45__Acids__124__" name="a D-amino acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__GAMMA__45__GLUTAMYLCYSTEINE" name="L-&amp;gamma;-glutamylcysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP" name="GDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="APS" name="adenosine 5&apos;-phosphosulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" name="an L-1-phosphatidyl-ethanolamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__SEDOHEPTULOSE__45__7__45__P" name="D-sedoheptulose-7-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROFOLATE" name="7,8-dihydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Acceptor__124__" name="an oxidized electron acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ILE" name="L-isoleucine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__ADENOSYLMETHIONINAMINE" name="S-adenosyl-L-methioninamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N4__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__F6" name="N4-{N-acetyl-&amp;beta;-D-glucosaminyl-(1,2)-&amp;alpha;-D-mannosyl-(1,3)-[N-acetyl-&amp;beta;-D-glucosaminyl-(1,2)-&amp;alpha;-D-mannosyl-(1,6)]-&amp;beta;-D-mannosyl-(1,4)-N-acetyl-&amp;beta;-D-glucosaminyl-(1,4)-[&amp;alpha;-L-fucosyl-(1,6)]-N-acetyl-&amp;beta;-D-glucosaminyl}asparagine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__302" name="D-aspartate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ARG" name="L-arginine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__CHLORO__45__24__45__DINITROBENZENE" name="1-chloro-2,4-dinitrobenzene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7213" name="[heparan sulfate]-N-sulfoglucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__882" name="1,6-anhMurNAc" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXY__45__PROPIONATE" name="3-hydroxypropionate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="IMP" name="inosine-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROCOLLAGEN__45__5__45__HYDROXY__45__L__45__LYSINE" name="procollagen-5-hydroxy-L-lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MANNOSE" name="D-mannose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7418" name="coumarinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7417" name="coumarinic acid-&amp;beta;-D-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__ALLANTOIN" name="S-allantoin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHATIDYLINOSITOL__45__345__45__TRIPHOSPHATE" name="1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__335" name="(R)-3-hydroxybutanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__2__45__HYDROXYACYLSPHINGOSINE" name="2-(2-hydroxyacyl)sphingosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP__45__D__45__GLUCOSE" name="GDP-&amp;alpha;-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NUC__45__5__45__PHOSPHATE" name="a nucleoside-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LIPOAMIDE" name="lipoamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__331" name="3-dehydroecdysone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_23__45__EPOXY__45__23__45__DIHYDRO__45__2__45__METHYL__45__14__45__NAPHTHOQ" name="vitamin K 2,3-epoxide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTEIN__45__L__45__BETA__45__ISOSPARTATE__45__METHYL__45__ESTERS" name="a protein L-&amp;beta;-isoaspartate &amp;alpha;-methyl ester" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FORMYL__45__L__45__METHIONYL__45__PEPTIDE" name="formyl-L-methionyl peptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ASPARTATE" name="L-aspartate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ASN" name="L-asparagine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MALONATE__45__S__45__ALD" name="malonate semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UBIQUINONE__45__8" name="ubiquinone-8" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Donor__45__H2__124__" name="a reduced electron acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACRYLATE" name="acrylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__CYSTATHIONINE" name="cystathionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="INOSITOL__45__1__45__3__45__4__45__TRIPHOSPHATE" name="D-myo-inositol (1,3,4)-trisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HYPOTAURINE" name="hypotaurine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" name="D-myo-inositol (3)-monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__2__45__Arylethylamines__124__" name="a 2-arylethylamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TREHALOSE__45__6P" name="trehalose 6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYADENOSINE" name="deoxyadenosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ATP" name="ATP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__N__45__ACETYL__45__GALACTOSAMINE" name="UDP-N-acetyl-D-galactosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSINE5TRIPHOSPHO5ADENOSINE" name="5&apos;,5&apos;-diadenosine triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OXALYL__45__COA" name="oxalyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GALACTOSE" name="&amp;beta;-D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLUCOSAMINYL__45__ETCETERA__45__MANNOSYL__45__R" name="(N-acetyl-&amp;beta;-D-glucosaminyl-1,2)-&amp;alpha;-D-mannosyl-1,3-(&amp;beta;-N-acetyl-D-glucosaminyl-1,2-&amp;alpha;-D-mannosyl-1,6)-&amp;beta;-D-mannosyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7000" name="isobutanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__318" name="monodehydroascorbate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCOLLATE" name="glycolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NADH__45__P__45__OR__45__NOP" name="NAD(P)H" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__TETRADECANOYLGLYCYL__45__PEPTIDE" name="N-tetradecanoylglycyl-peptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" name="dTDP-4-dehydro-6-deoxy-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CDPDIACYLGLYCEROL" name="a CDP-diacylglycerol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__LACTATE" name="D-lactate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" name="a 2,3,4-saturated fatty acyl CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__352" name="estradiol-17&amp;beta;" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__353" name="GDP-D-rhamnose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N4__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__F" name="N(4)-{N-acetyl-&amp;beta;-D-glucosaminyl-(1,2)-&amp;alpha;-D-mannosyl-(1,3)-[N-acetyl-&amp;beta;-D-glucosaminyl-(1,2)-&amp;alpha;-D-mannosyl-(1,6)]-&amp;beta;-D-mannosyl-(1,4)-N-acetyl-&amp;beta;-D-glucosaminyl-(1,4)-[&amp;alpha;-L-fucosyl-(1,3)]-N-acetyl-&amp;beta;-D-glucosaminyl}asparagine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXY__45__PROPIONYL__45__COA" name="3-hydroxypropionyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CANAVANINE" name="canavanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOSE__45__1__45__ARSENATE" name="ribose-1-arsenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__3__45__HYDROXYACYL__45__COA" name="a (3S)-3-hydroxyacyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ARSENATE" name="arsenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TYR" name="L-tyrosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5678__45__TETRAHYDROPTERIDINE" name="5,6,7,8-tetrahydropteridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__D__45__GLUCOSAMINE" name="N-acetyl-D-glucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8188" name="glycoprotein N-acetyl-D-galactosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THREO__45__DS__45__ISO__45__CITRATE" name="D-isocitrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LYS" name="L-lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_44__45__DIMETHYL__45__5ALPHA__45__CHOLEST__45__7__45__EN__45__3BET" name="4,4-dimethyl-5&amp;alpha;-cholest-7-en-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENYLOSUCC" name="adenylo-succinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__BETA__45__D__45__GALACTOSYL__45__2__45__2__45__HYDROXYACYLS" name="1-(&amp;beta;-D-galactosyl)-2-(2-hydroxyacyl)sphingosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAL_PHOSPHATE" name="pyridoxal 5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DUMP" name="dUMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1242" name="3-keto-&amp;beta;-D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OXALO__45__SUCCINATE" name="oxalosuccinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__DOPACHROME" name="L-dopachrome" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTOPORPHYRIN_IX" name="protoporphyrin IX" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="A__45__3__45__OXO__45__ACYL__45__COA" name="a 3-oxo-acyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__371" name="1-octanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UROPORPHYRINOGEN__45__III" name="uroporphyrinogen-III" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCERATE" name="D-glycerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7035" name="2-phenylethanol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__374" name="sepiapterin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIETHYLTHIOPHOSPHATE" name="diethylthiophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__L__45__1__45__phosphatidyl__45__inositols__124__" name="an L-1-phosphatidyl-inositol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7037" name="methionol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7036" name="3-methylthiopropanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7031" name="3-methylbutanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7032" name="isoamyl alcohol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7033" name="2-methylbutanol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_56__45__DIHYDROXYINDOLE__45__2__45__CARBOXYLATE" name="5,6-dihydroxyindole-2-carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="POLYPEPTIDE" name="a polypeptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__369" name="L-iditol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Protein__45__L__45__lysine__124__" name="a protein L-lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Keto__45__Acid__124__" name="a keto acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CHOLESTEROL" name="cholesterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__BETA__45__GLUCOSAMINYLAMINE" name="N-acetyl-&amp;beta;-glucosaminylamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROXY__45__ACETONE__45__PHOSPHATE" name="dihydroxy-acetone phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HYDROXYMETHYLBILANE" name="hydroxymethylbilane" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Nucleoside__45__Triphosphates__124__" name="a nucleoside triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLC" name="&amp;beta;-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Carboxylates__124__" name="a carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__190" name="N-acetylglucosaminyl-diphosphodolichol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__782" name="3,4-dihydroxyphenylacetate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__194" name="4-nitrophenyl phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__195" name="octanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__196" name="octanoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__MALEYL__45__ACETOACETATE" name="4-maleyl-acetoacetate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYLARYLAMINE" name="N-acetylarylamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__SULFINYL__45__PYRUVATE" name="3-sulfinyl-pyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LONG__45__CHAIN__45__KETONE" name="a ketone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__397" name="S-methyl-L-methionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OXIDIZED__45__ACCEPTOR" name="an oxidized acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Fatty__45__Acids__124__" name="a fatty acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HISTAMINE" name="histamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SACCHAROPINE" name="saccharopine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__D__45__GALACTOSE" name="&amp;alpha;-D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__S__45__Substituted__45__Glutathione__124__" name="a glutathione-toxin conjugate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__TYROSINE__45__METHYL__45__ESTER" name="L-tyrosine-methyl-ester" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__189" name="CMP-N-acylneuraminate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__385" name="1,2-benzoquinone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__592" name="4-guanidinobutyrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__596" name="NG,NG-dimethyl-L-arginine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP" name="UDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__2__45__Oxo__45__Acids__124__" name="a 2-oxo acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PORPHOBILINOGEN" name="porphobilinogen" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__3141" name="genistein" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__3__45__CARBOXY__45__3__45__AMINOPROPYL__45__L__45__HISTIDINE" name="2-(3-carboxy-3-aminopropyl)-L-histidine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACYL__45__COA" name="an acyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="P__45__NITROPHENOL" name="4-nitrophenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FRUCTOSE__45__16__45__DIPHOSPHATE" name="fructose-1,6-bisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NICOTINAMIDE_RIBOSE" name="nicotinamide riboside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__D__45__MANNOSYL__45__13__45__R1__45__BETA__45__D__45__MANNOSY" name="&amp;alpha;-D-mannosyl-1,3-(R1)-&amp;beta;-D-mannosyl-R2" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Fatty__45__Aldehydes__124__" name="a fatty aldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHENYL__45__PYRUVATE" name="phenylpyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PECTATE" name="a pectate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NOREPINEPHRINE" name="noradrenaline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSYL__45__HOMO__45__CYS" name="S-adenosyl-L-homocysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ARGININO__45__SUCCINATE" name="L-arginino-succinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MANNOSYL__45__ETCETERA__45__MANNOSYL__45__R" name="&amp;alpha;-D-mannosyl-1,6-(N-acetyl-&amp;beta;-D-glucosaminyl-1,2-&amp;alpha;-D-mannosyl-1,3)-&amp;beta;-D-mannosyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MET" name="L-methionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="CPD__45__2747" name="cotinine-glucuronide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACRYLYL__45__COA" name="acrylyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__2742" name="cotinine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THF__45__GLU__45__N" name="a tetrahydrofolate polyglutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHATIDYLCHOLINE" name="a phosphatidylcholine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__2744" name="nicotine-Glucuronide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__2743" name="nicotine-1&apos;-N-oxide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MALTOPENTAOSE" name="maltopentaose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7610" name="soyasapogenol B" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DGTP" name="dGTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7612" name="soyasapogenol B-3-O-&amp;beta;-glucuronide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SORBITOL" name="D-sorbitol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENINE" name="adenine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HOMOGENTISATE" name="homogentisate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__P__45__HYDROXYPYRUVATE" name="3-phospho-hydroxypyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Primary__45__Alcohols__124__" name="a primary alcohol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_44__45__DIMETHYL__45__824__45__CHOLESTADIENOL" name="4,4-dimethylzymosterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__KYNURENINE" name="kynurenine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Long__45__linear__45__glucans__124__" name="a long-linear glucan" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8630" name="(5&apos;)ppPur-mRNA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8631" name="G(5&apos;)ppPur-mRNA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SO3" name="sulfite" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NN__45__DIMETHYLANILINE__45__N__45__OXIDE" name="nn-dimethylaniline-n-oxide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" name="1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__7__45__Beta__45__Hydroxysteroids__124__" name="a 7-&amp;beta;-hydroxysteroid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Alcohols__124__" name="an alcohol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__10__45__METHENYL__45__THF" name="5,10-methenyltetrahydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Myo__45__inositol__45__penta__45__kis__45__phosphates__124__" name="a myo-inositol penta kis phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TETRADECANOYL__45__COA" name="myristoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UREA" name="urea" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CHONDROITIN__45__6__45__SULFATE" name="chondroitin-6-sulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DATP" name="dATP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8624" name="peptidylproline (&amp;omega; = 180)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8625" name="peptidylproline (&amp;omega; = 0)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DCTP" name="dCTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8622" name="&amp;beta;-D-glucuronosyl-(1->3)-&amp;beta;-D-galactosyl-(1->3)-&amp;beta;-D-galactosyl-(1->4)-&amp;beta;-D-xylosyl-proteoglycan" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8628" name="m7G(5&apos;)pppAm" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8629" name="m7G(5&apos;)pppm6Am" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYNUCLEOTIDESM" name="(deoxynucleotides)(m)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
</listOfSpecies>
<listOfReactions>
  <reaction id="ATP__45__CITRATE__45__PRO__45__S__45____45__LYASE__45__RXN" name="ATP-citrate (pro-S-)-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ATPCL ) or ( ATPCL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ATP citrate lyase CG8322-PB, isoform B ) or ( ATP citrate lyase CG8322-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: acetyl-CoA biosynthesis (from citrate)</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: OXALACETIC_ACID</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AKBLIG__45__RXN" name="Glycine C-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG10361 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG10361 CG10361-PA )</html:p>
<html:p>SUBSYSTEM: threonine degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.29</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__OXOBUT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LONG__45__CHAIN__45__ENOYL__45__COA__45__HYDRATASE__45__RXN" name="Long-chain-enoyl-CoA hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG4389 ) or ( CG4389 ) or ( CG4389 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG4389 CG4389-PB, isoform B ) or ( CG4389 CG4389-PC, isoform C ) or ( CG4389 CG4389-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.74</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GST__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG17639 ) or ( GstE10 ) or ( CG1702 ) or ( CG33177 ) or ( GstD4 ) or ( GstS1 ) or ( CG6776 ) or ( CG1681 ) or ( GstD8 ) or ( GstD2 ) or ( GstE9 ) or ( gfzf ) or ( GstD1 ) or ( GstE1 ) or ( Mgstl ) or ( CG6673 ) or ( GstE3 ) or ( GstD7 ) or ( GstD6 ) or ( GstD9 ) or ( GstE2 ) or ( GstE5 ) or ( Mgstl ) or ( GstD1 ) or ( CG11784 ) or ( CG9362 ) or ( gfzf ) or ( CG6662 ) or ( se ) or ( GstE4 ) or ( GstD3 ) or ( GstS1 ) or ( GstE6 ) or ( GstS1 ) or ( CG9363 ) or ( CG4688 ) or ( CG6673 ) or ( CG16936 ) or ( CG9363 ) or ( GstD5 ) or ( GstD10 ) or ( CG9363 ) or ( GstE7 ) or ( CG5224 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG17639 CG17639-PA ) or ( Glutathione S transferase E10 CG17522-PA ) or ( CG1702 CG1702-PA ) or ( CG33177 CG33177-PA ) or ( Glutathione S transferase D23 ) or ( Glutathione S transferase S1 CG8938-PC, isoform C ) or ( CG6776 CG6776-PA ) or ( CG1681 CG1681-PA ) or ( Glutathione S transferase D27 ) or ( Glutathione S transferase D2 CG4181-PA ) or ( Glutathione S transferase E9 CG17534-PA ) or ( GST-containing FLYWCH zinc-finger protein CG33546-PC, isoform C ) or ( CG10045 Glutathione S-transferase ) or ( Glutathione S transferase E1 CG5164-PA ) or ( Microsomal glutathione S-transferase-like CG1742-PA, isoform A ) or ( CG6673 CG6673-PA, isoform A ) or ( Glutathione S transferase E3 CG17524-PA ) or ( Glutathione S transferase D26 ) or ( Glutathione S transferase D25 ) or ( Glutathione S transferase D9 CG10091-PA ) or ( Glutathione S transferase E2 CG17523-PA ) or ( Glutathione S transferase E5 CG17527-PA ) or ( Microsomal glutathione S-transferase-like CG1742-PB, isoform B ) or ( CG10045 Glutathione S-transferase ) or ( CG11784 CG11784-PA ) or ( CG9362 CG9362-PA ) or ( GST-containing FLYWCH zinc-finger protein CG33546-PB, isoform B ) or ( CG6662 CG6662-PA ) or ( CG6781-PA ) or ( Glutathione S transferase E4 CG17525-PA ) or ( Glutathione S transferase D22 ) or ( Glutathione S transferase S1 CG8938-PB, isoform B ) or ( Glutathione S transferase E6 CG17530-PA ) or ( Glutathione S transferase S1 CG8938-PA, isoform A ) or ( CG9363 CG9363-PA, isoform A ) or ( CG4688 CG4688-PA ) or ( CG6673 CG6673-PB, isoform B ) or ( CG16936 CG16936-PA ) or ( CG9363 CG9363-PC, isoform C ) or ( Glutathione S transferase D24 ) or ( Glutathione S transferase D10 CG18548-PA ) or ( CG9363 CG9363-PB, isoform B ) or ( Glutathione S transferase E7 CG17531-PA ) or ( CG5224 CG5224-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__CHLORO__45__24__45__DINITROBENZENE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="S__45__24__45__DINITROPHENYLGLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__45__PHOSPHATIDYLINOSITOL__45__KINASE__45__RXN" name="1-phosphatidylinositol 4-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( fwd ) or ( fwd ) or ( fwd ) or ( Pi4KIIalpha ) or ( Pi4KIIalpha ) or ( CG10260 ) or ( Pi4KIIalpha )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( four wheel drive CG7004-PB, isoform B ) or ( four wheel drive CG7004-PA, isoform A ) or ( four wheel drive CG7004-PC, isoform C ) or ( Pi4KIIalpha CG2929-PA, isoform A ) or ( Pi4KIIalpha CG2929-PC, isoform C ) or ( CG10260 CG10260-PB ) or ( Pi4KIIalpha CG2929-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.67</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__L__45__1__45__phosphatidyl__45__inositols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1108" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEPARITIN__45__SULFOTRANSFERASE__45__RXN" name="Heparitin sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( sfl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfateless CG8339-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.8</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HEPARIN__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7213" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__22" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9510 ) or ( CG9510 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9510-PB, isoform B ) or ( CG9510-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CANAVANINOSUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
      <speciesReference species="CANAVANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MONOPHENOL__45__MONOOXYGENASE__45__RXN" name="Monophenol monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG8193 ) or ( Bc ) or ( Dox-A3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG8193 CG8193-PA ) or ( Black cells CG5779-PA ) or ( Diphenol oxidase A3 CG2952-PA )</html:p>
<html:p>SUBSYSTEM: betalain biosynthesis (to betalamic acid)</html:p>
<html:p>PROTEIN_CLASS: 1.14.18.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: DOPAQUINONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYR" stoichiometry="1"/>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOPAQUINONE" stoichiometry="1"/>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERPHOSPHA__45__RXN" name="Phosphoserine phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( aay )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( astray CG3705-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Phosphoserines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Serines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDHDEHYDROG__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh-III ) or ( CG9629 ) or ( Aldh-III ) or ( CG31075 ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aldehyde dehydrogenase type III CG11140-PD, isoform D ) or ( CG9629 CG9629-PA ) or ( Aldehyde dehydrogenase type III CG11140-PA, isoform A ) or ( CG31075 CG31075-PA ) or ( Aldehyde dehydrogenase type III CG11140-PH, isoform H ) or ( Aldehyde dehydrogenase type III CG11140-PE, isoform E ) or ( Aldehyde dehydrogenase type III CG11140-PC, isoform C ) or ( Aldehyde dehydrogenase CG3752-PA ) or ( Aldehyde dehydrogenase type III CG11140-PB, isoform B ) or ( Aldehyde dehydrogenase type III CG11140-PI, isoform I ) or ( Aldehyde dehydrogenase type III CG11140-PG, isoform G ) or ( Aldehyde dehydrogenase type III CG11140-PF, isoform F )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANOSINE__45__DIPHOSPHATASE__45__RXN" name="Guanosine-diphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NTPase ) or ( NTPase ) or ( NTPase ) or ( NTPase )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NTPase CG3059-PC, isoform C ) or ( NTPase CG3059-PD, isoform D ) or ( NTPase CG3059-PB, isoform B ) or ( NTPase CG3059-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.42</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCINATE__45__SEMIALDEHYDE__45__DEHYDROGENASE__45__RXN" name="Succinate-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG4685 ) or ( CG4685 ) or ( CG4685 ) or ( CG4685 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG4685 CG4685-PB, isoform B ) or ( CG4685 CG4685-PD, isoform D ) or ( CG4685 CG4685-PC, isoform C ) or ( CG4685 CG4685-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation I</html:p>
<html:p>SUBSYSTEM: glutamate degradation IV</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.24</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R15__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1461 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1461 CG1461-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Amino__45__Acids__45__20__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__479" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="__124__Keto__45__Acid__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="F16ALDOLASE__45__RXN" name="Fructose-bisphosphate aldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ald ) or ( Ald ) or ( Ald ) or ( Ald ) or ( Ald ) or ( CG5432 ) or ( Ald ) or ( Ald ) or ( Ald )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aldolase CG6058-PC, isoform C ) or ( Aldolase CG6058-PE, isoform E ) or ( Aldolase CG6058-PD, isoform D ) or ( Aldolase CG6058-PF, isoform F ) or ( Aldolase CG6058-PB, isoform B ) or ( CG5432 CG5432-PA ) or ( Aldolase CG6058-PG, isoform G ) or ( Aldolase CG6058-PA, isoform A ) or ( Aldolase CG6058-PH, isoform H )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7607" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG2862 ) or ( CG11883 ) or ( CG1961 ) or ( CG11883 ) or ( CG2862 ) or ( CG4827 ) or ( CG11883 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG11126 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2862 CG2862-PA, isoform A ) or ( CG11883 CG11883-PA, isoform A ) or ( CG1961 CG1961-PA ) or ( CG11883 CG11883-PC, isoform C ) or ( CG2862 CG2862-PB, isoform B ) or ( CG4827 CG4827-PA ) or ( CG11883 CG11883-PB, isoform B ) or ( CG32549 CG32549-PE, isoform E ) or ( CG32549 CG32549-PA, isoform A ) or ( CG32549 CG32549-PB, isoform B ) or ( CG32549 CG32549-PC, isoform C ) or ( CG32549 CG32549-PF, isoform F ) or ( CG32549 CG32549-PD, isoform D ) or ( CG11126 CG11126-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7609" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG2862 ) or ( CG11883 ) or ( CG1961 ) or ( CG11883 ) or ( CG2862 ) or ( CG4827 ) or ( CG11883 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG11126 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2862 CG2862-PA, isoform A ) or ( CG11883 CG11883-PA, isoform A ) or ( CG1961 CG1961-PA ) or ( CG11883 CG11883-PC, isoform C ) or ( CG2862 CG2862-PB, isoform B ) or ( CG4827 CG4827-PA ) or ( CG11883 CG11883-PB, isoform B ) or ( CG32549 CG32549-PE, isoform E ) or ( CG32549 CG32549-PA, isoform A ) or ( CG32549 CG32549-PB, isoform B ) or ( CG32549 CG32549-PC, isoform C ) or ( CG32549 CG32549-PF, isoform F ) or ( CG32549 CG32549-PD, isoform D ) or ( CG11126 CG11126-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENETHFDEHYDROG__45__NADP__45__RXN" name="Methylenetetrahydrofolate dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pug ) or ( pug ) or ( Nmdmc ) or ( Nmdmc ) or ( pug ) or ( pug )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pugilist CG4067-PD, isoform D ) or ( pugilist CG4067-PA, isoform A ) or ( NAD-dependent methylenetetrahydrofolate dehydrogenase CG18466-PB, isoform B ) or ( NAD-dependent methylenetetrahydrofolate dehydrogenase CG18466-PA, isoform A ) or ( pugilist CG4067-PC, isoform C ) or ( pugilist CG4067-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation V (tetrahydrofolate pathway)</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__SYN__45__NH3__45__RXN" name="GMP synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bur )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( burgundy CG9242-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1483" name="Ferroxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5959 ) or ( CG3759 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5959 CG5959-PA ) or ( CG3759 CG3759-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.16.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FE__43__2" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FE__43__3" stoichiometry="4"/>
    </listOfProducts>
  </reaction>
  <reaction id="SARCOSINE__45__DEHYDROGENASE__45__RXN" name="Sarcosine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6385 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6385 CG6385-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYL__45__SULFOTRANSFERASE__45__RXN" name="Aryl sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG16733 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG16733 CG16733-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.1</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aryl__45__sulfates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__6__46__1__46__17__45__RXN" name="Bis(5&apos;-nucleosyl)-tetraphosphatase (asymmetrical)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Apf )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diadenosine tetraphosphate hydrolase CG31713-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__609" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSE__45__DEHYDROGENASE__45__ACCEPTOR__45__RXN" name="Glucose dehydrogenase (acceptor)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG12539 ) or ( Gld ) or ( CG12398 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG12539 CG12539-PA ) or ( Glucose dehydrogenase CG1152-PA ) or ( CG12398 CG12398-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.10</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANPHOSPHOR__45__RXN" name="Guanosine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG16758 ) or ( CG16758 ) or ( CG16758 ) or ( CG16758 ) or ( CG18128 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG16758 CG16758-PD, isoform D ) or ( CG16758 CG16758-PE, isoform E ) or ( CG16758 CG16758-PB, isoform B ) or ( CG16758 CG16758-PF, isoform F ) or ( CG18128 CG18128-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__4__46__1__45__RXN" name="Pyrimidodiazepine synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( se )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6781-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.4.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Pyrimidodiazepines__124__" stoichiometry="1"/>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
      <speciesReference species="_6__45__PYRUVOYL__45__5678__45__TETRAHYDROPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLDIALKYL__45__PHOSPHATASE__45__RXN" name="aryldialkyl phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG18473 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG18473 CG18473-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PARATHION" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIETHYLTHIOPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__198__45__RXN" name="Phosphatidylinositol N-acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG12077 ) or ( CG6401 ) or ( Gpi1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG12077 CG12077-PA ) or ( CG6401 CG6401-PA ) or ( Gpi1 CG32578-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.198</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__L__45__1__45__phosphatidyl__45__inositols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__452" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALKYLGLYCERONE__45__PHOSPHATE__45__SYNTHASE__45__RXN" name="Alkylglycerone-phosphate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG10253 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG10253 CG10253-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.26</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__a__45__long__45__chain__45__alcohol__124__" stoichiometry="1"/>
      <speciesReference species="_1__45__ACYL__45__GLYCERONE__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__Chain__45__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="_1__45__ALKYL__45__GLYCERONE__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1826" name="starch phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GlyP ) or ( CG16965 ) or ( GlyP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glycogen phosphorylase CG7254-PA, isoform A ) or ( CG16965 CG16965-PA ) or ( Glycogen phosphorylase CG7254-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__linear__45__glucans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1828" name="disproportionating enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9485 ) or ( CG9485 ) or ( CG9485 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9485 CG9485-PA, isoform A ) or ( CG9485 CG9485-PB, isoform B ) or ( CG9485 CG9485-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.25</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Short__45__glucans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__linear__45__glucans__124__" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__10" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1315 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1315 CG1315-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="O__45__UREIDOHOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CANAVANINOSUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTEIN__45__LYSINE__45__6__45__OXIDASE__45__RXN" name="Protein-lysine 6-oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( lox ) or ( lox2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lysyl oxidase-like CG11335-PA ) or ( lysyl oxidase-like 2 CG4402-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.13</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__L__45__lysine__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8649" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__761" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tps1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Trehalose-6-phosphate synthase 1 CG4104-PA )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
      <speciesReference species="ADP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALCOHOL__45__DEHYDROGENASE__45__NADPORNOP__43____45__RXN" name="Alcohol dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG2767 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2767 CG2767-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.2</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__969" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG18003 ) or ( CG18003 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG18003 CG18003-PB, isoform B ) or ( CG18003-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROTOX__45__RXN" name="Dihydroorotate oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( su(r) ) or ( Dhod ) or ( Dhod ) or ( Dhod ) or ( su(r) )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2194-PB, isoform B ) or ( Dihydroorotate dehydrogenase CG9741-PB, isoform B ) or ( Dihydroorotate dehydrogenase CG9741-PA, isoform A ) or ( Dihydroorotate dehydrogenase CG9741-PC, isoform C ) or ( CG2194-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_13__45__BETA__45__GLUCAN__45__SYNTHASE__45__RXN" name="1,3-&amp;beta;-glucan synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG2781 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2781 CG2781-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.34</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__40__1__44__3__45__BETA__45__D__45__GLUCOSYL__41____40__N__41__" stoichiometry="1"/>
      <speciesReference species="__124__1__45__3__45__beta__45__D__45__Glucans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__40__1__44__3__45__BETA__45__D__45__GLUCOSYL__41____40__N__43__1__41__" stoichiometry="1"/>
      <speciesReference species="__124__1__45__3__45__beta__45__D__45__Glucans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__3__45__PHOSPHATE__45__DEHYDROGENASE__45__RXN" name="Glycerol-3-phosphate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( l(2)k05713 ) or ( l(2)k05713 ) or ( l(2)k05713 ) or ( CG7311 ) or ( CG31169 ) or ( Dhc36C ) or ( CG8046 ) or ( CG31169 ) or ( l(2)k05713 ) or ( CG2137 ) or ( Gpdh ) or ( Gpdh ) or ( CG8046 ) or ( CG3215 ) or ( Gpdh ) or ( CG7311 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lethal (2) k05713 CG8256-PA, isoform A ) or ( lethal (2) k05713 CG8256-PC, isoform C ) or ( lethal (2) k05713 CG8256-PB, isoform B ) or ( CG7311 CG7311-PB, isoform B ) or ( CG31169 CG31169-PA, isoform A ) or ( Dynein heavy chain at 36C CG5526-PA ) or ( CG8046 CG8046-PB, isoform B ) or ( CG31169 CG31169-PB, isoform B ) or ( lethal (2) k05713 CG8256-PD, isoform D ) or ( CG2137 CG2137-PA ) or ( Glycerol 3 phosphate dehydrogenase CG9042-PC, isoform C ) or ( Glycerol 3 phosphate dehydrogenase CG9042-PB, isoform B ) or ( CG8046 CG8046-PA, isoform A ) or ( CG3215 CG3215-PA ) or ( Glycerol 3 phosphate dehydrogenase CG9042-PA, isoform A ) or ( CG7311 CG7311-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1823" name="&amp;alpha;-amylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Amy-d ) or ( Amy-p ) or ( Amyrel )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Amylase distal CG17876-PA ) or ( Amylase proximal CG18730-PA ) or ( Amyrel CG8221-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Starch__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Large__45__branched__45__glucans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCISOM__45__RXN" name="Xylose isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( beta4GalNAcTA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta4GalNAcTA CG8536-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1825" name="&amp;alpha;-amylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Amy-d ) or ( Amy-p ) or ( Amyrel )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Amylase distal CG17876-PA ) or ( Amylase proximal CG18730-PA ) or ( Amyrel CG8221-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__linear__45__glucans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Short__45__glucans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TREHALOSE6PSYN__45__RXN" name="&amp;alpha;,&amp;alpha;-trehalose-phosphate synthase (UDP-forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tps1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Trehalose-6-phosphate synthase 1 CG4104-PA )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.15</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STEROID__45__DELTA__45__ISOMERASE__45__RXN" name="Steroid &amp;delta;-isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7724 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7724 CG7724-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__3__45__oxo__45__D5__45__steroids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__3__45__Oxo__45__Delta__45__4__45__Steroids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANSALDOL__45__RXN" name="Transaldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Tal )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Tal CG2827-PA )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__CAROTENE__45__1515__45__DIOXYGENASE__45__RXN" name="&amp;beta;-carotene 15,15&apos;-dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ninaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-carotene dioxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.36</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__129" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RETINAL" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__117__45__RXN" name="Dolichyl-phosphate &amp;beta;-glucosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7870 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7870 CG7870-PA )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.117</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__166" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DOLICHOL__45__KINASE__45__RXN" name="Dolichol kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG8311 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG8311 CG8311-PA )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.108</html:p>
<html:p>COFACTOR: CDP</html:p>
<html:p>COFACTOR: CTP</html:p>
<html:p>SIDE: CDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOLICHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP_TO_GDP_COF_RXN" name="GTP_TO_GDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__NITROPHENYLPHOSPHATASE__45__RXN" name="4-nitrophenylphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG11291 ) or ( CG5577 ) or ( CG2680 ) or ( CG17294 ) or ( CG32487 ) or ( CG32488 ) or ( CG5567 ) or ( CG10352 ) or ( CG15739 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG11291 CG11291-PA ) or ( CG5577 CG5577-PA ) or ( CG2680 CG2680-PA ) or ( CG17294 CG17294-PA ) or ( CG32487 CG32487-PA ) or ( CG32488 CG32488-PA ) or ( CG5567 CG5567-PA ) or ( CG10352 CG10352-PA ) or ( CG15739 CG15739-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.41</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__194" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADPH_TO_NADP_COF_RXN" name="NADPH_TO_NADP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NADPH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6102" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG2543 ) or ( CG31773 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2543 CG2543-PA ) or ( CG31773 CG31773-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THF" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5725" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOLIPASE__45__A1__45__RXN" name="Phospholipase A1" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG17192 ) or ( CG10163 ) or ( sxe2 ) or ( CG8552 ) or ( CG6296 ) or ( CG4267 ) or ( CG6295 ) or ( CG6271 ) or ( CG17191 ) or ( CG6277 ) or ( CG6283 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG17192 CG17192-PA ) or ( CG10163 CG10163-PA ) or ( sex-specific enzyme 2 CG4979-PA ) or ( CG8552 CG8552-PA ) or ( CG6296 CG6296-PA ) or ( CG4267 CG4267-PA ) or ( CG6295 CG6295-PA ) or ( CG6271 CG6271-PA ) or ( CG17191 CG17191-PA ) or ( CG6277 CG6277-PA ) or ( CG6283 CG6283-PA )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.32</html:p>
<html:p>SIDE: __124__Carboxylates__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="__124__2__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__77__45__RXN" name="Protein-L-isoaspartate(D-aspartate) O-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pcmt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Protein-L-isoaspartate (D-aspartate) O-methyltransferase CG2152-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.77</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTEIN__45__L__45__BETA__45__ISOASPARTATES" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTEIN__45__L__45__BETA__45__ISOSPARTATE__45__METHYL__45__ESTERS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__N__45__ACETYL__45__GALACTOSAMINE_TO_UDP_COF_RXN" name="UDP-N-ACETYL-GALACTOSAMINE_TO_UDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__GALACTOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__122__45__RXN" name="Glycoprotein-N-acetylgalactosamine 3-&amp;beta;-galactosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9520 ) or ( CG9520 ) or ( CG9520 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9520 CG9520-PA, isoform A ) or ( CG9520 CG9520-PC, isoform C ) or ( CG9520 CG9520-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.122</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8188" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GALACTOSAMINY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLN_TO_GLT_COF_RXN" name="GLN_TO_GLT_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GLN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__41__45__RXN" name="Polypeptide N-acetylgalactosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pgant35A ) or ( CG10000 ) or ( pgant6 ) or ( CG7579 ) or ( pgant5 ) or ( GalNAc-T1 ) or ( CG31776 ) or ( pgant3 ) or ( GalNAc-T1 ) or ( pgant4 ) or ( CG30463 ) or ( CG30463 ) or ( pgant8 ) or ( CG30463 ) or ( CG30463 ) or ( CG30463 ) or ( GalNAc-T2 ) or ( pgant6 ) or ( CG7304 ) or ( pgant5 ) or ( pgant2 ) or ( GalNAc-T2 ) or ( CG7304 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Polypeptide N-acetylgalactosaminyltransferase 35A CG7480-PA ) or ( CG10000 CG10000-PA ) or ( polypeptide GalNAc transferase 6 CG2103-PB, isoform B ) or ( CG7579 CG7579-PA ) or ( polypeptide GalNAc transferase 5 CG31651-PA, isoform A ) or ( GalNAc-T1 CG8182-PA, isoform A ) or ( CG31776 CG31776-PA ) or ( polypeptide GalNAc transferase 3 CG4445-PA ) or ( GalNAc-T1 CG8182-PB, isoform B ) or ( polypeptide GalNAc transferase 4 CG31956-PA ) or ( CG30463 CG30463-PB, isoform B ) or ( CG30463 CG30463-PC, isoform C ) or ( polypeptide GalNAc transferase 8 CG7297-PA ) or ( CG30463 CG30463-PA, isoform A ) or ( CG30463 CG30463-PE, isoform E ) or ( CG30463 CG30463-PD, isoform D ) or ( UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 CG6394-PA, isoform A ) or ( polypeptide GalNAc transferase 6 CG2103-PA, isoform A ) or ( CG7304 CG7304-PA, isoform A ) or ( polypeptide GalNAc transferase 5 CG31651-PB, isoform B ) or ( polypeptide GalNAc transferase 2 CG3254-PA ) or ( UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 CG6394-PB, isoform B ) or ( CG7304 CG7304-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.41</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__GALACTOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="POLYPEPTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GALACTOSAMINYL__45__POLYPEPTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SAICARSYN__45__RXN" name="Phosphoribosylaminoimidazole-succinocarboxamide synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG17024 ) or ( ade5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG17024 CG17024-PA ) or ( ade5 CG3989-PA )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMYLOMALT__45__RXN" name="4-&amp;alpha;-glucanotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9485 ) or ( CG9485 ) or ( CG9485 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9485 CG9485-PA, isoform A ) or ( CG9485 CG9485-PB, isoform B ) or ( CG9485 CG9485-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.25</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOTRIOSE" stoichiometry="1"/>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERTRANSAMPYR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG11899 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG11899 CG11899-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.52</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3OH__45__4P__45__OH__45__ALPHA__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__PHOSPHONOOXY__45__THREONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHORYL__45__RXN" name="Phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GlyP ) or ( CG16965 ) or ( GlyP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glycogen phosphorylase CG7254-PA, isoform A ) or ( CG16965 CG16965-PA ) or ( Glycogen phosphorylase CG7254-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANS__45__HEXAPRENYLTRANSTRANSFERASE__45__RXN" name="trans-hexaprenyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG31005 ) or ( CG10585 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG31005 CG31005-PA ) or ( CG10585 CG10585-PA )</html:p>
<html:p>SUBSYSTEM: heptaprenyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.30</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALL__45__TRANS__45__HEXAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALL__45__TRANS__45__HEPTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R314__45__RXN" name="Amidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7910 ) or ( CG5191 ) or ( CG8839 ) or ( gatA ) or ( CG5191 ) or ( CG5191 ) or ( CG8839 ) or ( CG5191 ) or ( CG5191 ) or ( PGRP-LB ) or ( PGRP-LB ) or ( CG5112 ) or ( CG8839 ) or ( CG7900 ) or ( CG8839 ) or ( PGRP-LB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7910 CG7910-PA ) or ( CG5191 CG5191-PD, isoform D ) or ( CG8839 CG8839-PC, isoform C ) or ( benedict ) or ( CG5191 CG5191-PC, isoform C ) or ( CG5191 CG5191-PA, isoform A ) or ( CG8839 CG8839-PD, isoform D ) or ( CG5191 CG5191-PB, isoform B ) or ( CG5191 CG5191-PE, isoform E ) or ( Peptidoglycan recognition protein LB CG14704-PB, isoform B ) or ( Peptidoglycan recognition protein LB CG14704-PA, isoform A ) or ( CG5112 CG5112-PA ) or ( CG8839 CG8839-PA, isoform A ) or ( CG7900 CG7900-PB ) or ( CG8839 CG8839-PE, isoform E ) or ( Peptidoglycan recognition protein LB CG14704-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URPHOS__45__RXN" name="Uridine phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG17224 ) or ( CG3788 ) or ( CG6330 ) or ( CG17224 ) or ( CG6330 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG17224 CG17224-PA, isoform A ) or ( CG3788 CG3788-PA ) or ( CG6330 CG6330-PA, isoform A ) or ( CG17224 CG17224-PB, isoform B ) or ( CG6330 CG6330-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="URACIL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDEAM2__45__RXN" name="Cytidine deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG8360 ) or ( CG8353 ) or ( CG8349 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG8360 CG8360-PA ) or ( CG8353 CG8353-PA ) or ( CG8349 CG8349-PA )</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOLACTOSE__45__RXN" name="&amp;beta;-galactosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gal ) or ( Ect3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta galactosidase CG9092-PA ) or ( Ect3 CG3132-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.23</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOLACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1242" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__271__45__RXN" name="GDP-L-fucose synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gmd ) or ( Gmer )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-mannose 4,6-dehydratase CG8890-PA ) or ( GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase CG3495-PA )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis I (from GDP-D-mannose)</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.271</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALTODEXGLUCOSID__45__RXN" name="&amp;alpha;-glucosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG11909 ) or ( LvpD ) or ( CG6453 ) or ( CG7685 ) or ( CG14935 ) or ( CG14934 ) or ( CG14476 ) or ( CG11669 ) or ( CG14476 ) or ( CG8690 ) or ( CG8693 ) or ( CG33080 ) or ( CG33080 ) or ( CG14935 ) or ( LvpH ) or ( LvpL ) or ( CG14476 ) or ( CG14476 ) or ( CG14476 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG11909 CG11909-PA ) or ( Larval visceral protein D CG8694-PA ) or ( CG6453 CG6453-PA ) or ( CG7685 CG7685-PA ) or ( CG14935 CG14935-PA, isoform A ) or ( CG14934 CG14934-PA ) or ( CG14476 CG14476-PB, isoform B ) or ( CG11669 CG11669-PA ) or ( CG14476 CG14476-PC, isoform C ) or ( CG8690 CG8690-PA ) or ( CG8693 CG8693-PA ) or ( CG33080 CG33080-PB, isoform B ) or ( CG33080 CG33080-PA, isoform A ) or ( CG14935 CG14935-PB, isoform B ) or ( Larval visceral protein H CG8696-PA ) or ( Larval visceral protein L CG8695-PA ) or ( CG14476 CG14476-PA, isoform A ) or ( CG14476 CG14476-PD, isoform D ) or ( CG14476 CG14476-PE, isoform E )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.20</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4142" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh-III ) or ( CG9629 ) or ( Aldh-III ) or ( CG31075 ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aldehyde dehydrogenase type III CG11140-PD, isoform D ) or ( CG9629 CG9629-PA ) or ( Aldehyde dehydrogenase type III CG11140-PA, isoform A ) or ( CG31075 CG31075-PA ) or ( Aldehyde dehydrogenase type III CG11140-PH, isoform H ) or ( Aldehyde dehydrogenase type III CG11140-PE, isoform E ) or ( Aldehyde dehydrogenase type III CG11140-PC, isoform C ) or ( Aldehyde dehydrogenase CG3752-PA ) or ( Aldehyde dehydrogenase type III CG11140-PB, isoform B ) or ( Aldehyde dehydrogenase type III CG11140-PI, isoform I ) or ( Aldehyde dehydrogenase type III CG11140-PG, isoform G ) or ( Aldehyde dehydrogenase type III CG11140-PF, isoform F )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;alpha;-oxidation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERILEU__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1673 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1673 CG1673-PA )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation I</html:p>
<html:p>SUBSYSTEM: isoleucine degradation II</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ILE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__METHYL__45__VALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SEPIAPTERIN__45__REDUCTASE__45__RXN" name="Sepiapterin reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Es2 ) or ( Sptr ) or ( CG12116 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Es2 CG1474-PA ) or ( Sepiapterin reductase CG12117-PA ) or ( CG12116 CG12116-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.153</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BIOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__374" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCOSE_TO_UDP_COF_RXN" name="UDP-GLUCOSE_TO_UDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__1__46__2__45__RXN" name="Dihydropyrimidine dehydrogenase (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( su(r) ) or ( su(r) )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2194-PB, isoform B ) or ( CG2194-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.2</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DI__45__H__45__URACIL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIAMIN__45__PYROPHOSPHOKINASE__45__RXN" name="Thiamine pyrophosphokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG14721 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG14721 CG14721-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.2</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THIAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THIAMINE__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREDEHYD__45__RXN" name="Threonine dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG8129 ) or ( CG8129 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG8129 CG8129-PB, isoform B ) or ( CG8129 CG8129-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.19</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLNEURAMINATE__45__CYTIDYLYLTRANSFERASE__45__RXN" name="Acylneuraminate cytidylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG32220 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG32220 CG32220-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.43</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1119" stoichiometry="1"/>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__189" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_AMP_COF_RXN" name="ATP_TO_AMP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6601" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG4829 ) or ( CG4829 ) or ( CG4829 ) or ( CG4829 ) or ( CG1492 ) or ( CG17636 ) or ( CG6461 ) or ( CG4829 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG4829 CG4829-PD, isoform D ) or ( CG4829 CG4829-PE, isoform E ) or ( CG4829 CG4829-PA, isoform A ) or ( CG4829 CG4829-PB, isoform B ) or ( CG1492 CG1492-PA ) or ( CG17636 CG17636-PA ) or ( CG6461 CG6461-PA ) or ( CG4829 CG4829-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>PROTEIN_CLASS: 2.3.2.2</html:p>
<html:p>SIDE: __124__Amino__45__Acids__45__20__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="__124__Amino__45__Acids__45__20__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYS__45__GLY" stoichiometry="1"/>
      <speciesReference species="_5__45__L__45__GLUTAMYL__45__L__45__AMINO__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROTPDECARB__45__RXN" name="Orotidine-5&apos;-phosphate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( r-l )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UMP synthase )</html:p>
<html:p>SUBSYSTEM: uridine-5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.23</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OROTIDINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDEHYDE__45__DEHYDROGENASE__45__NADORNOP__43____45__RXN" name="Aldehyde dehydrogenase (NAD(P)+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aldehyde dehydrogenase type III CG11140-PD, isoform D ) or ( Aldehyde dehydrogenase type III CG11140-PA, isoform A ) or ( Aldehyde dehydrogenase type III CG11140-PH, isoform H ) or ( Aldehyde dehydrogenase type III CG11140-PE, isoform E ) or ( Aldehyde dehydrogenase type III CG11140-PC, isoform C ) or ( Aldehyde dehydrogenase type III CG11140-PI, isoform I ) or ( Aldehyde dehydrogenase type III CG11140-PB, isoform B ) or ( Aldehyde dehydrogenase type III CG11140-PG, isoform G ) or ( Aldehyde dehydrogenase type III CG11140-PF, isoform F )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.5</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAG6PDEACET__45__RXN" name="N-acetylglucosamine-6-phosphate deacetylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG17065 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG17065 CG17065-PA )</html:p>
<html:p>SUBSYSTEM: N-acetylglucosamine degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.25</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNITHINE__45__GLU__45__AMINOTRANSFORASE__45__RXN" name="Ornithine--oxo-acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Oat ) or ( CG8745 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ornithine aminotransferase precursor CG8782-PA ) or ( CG8745 CG8745-PA )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.13</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROT__45__RXN" name="Dihydroorotase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( r ) or ( r )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( rudimentary CG18572-PA, isoform A ) or ( rudimentary CG18572-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: uridine-5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMYUL__45__L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARNITINE__45__O__45__OCTANOYLTRANSFERASE__45__RXN" name="Carnitine O-octanoyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG12428 ) or ( CG12428 ) or ( CG12428 ) or ( CG12428 ) or ( CG12428 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG12428 CG12428-PB, isoform B ) or ( CG12428 CG12428-PC, isoform C ) or ( CG12428 CG12428-PD, isoform D ) or ( CG12428 CG12428-PA, isoform A ) or ( CG12428 CG12428-PE, isoform E )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.137</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OCTANOYL__45__COA" stoichiometry="1"/>
      <speciesReference species="CPD__45__196" stoichiometry="1"/>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="L__45__OCTANOYLCARNITINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6902" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7433 ) or ( CG7433 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7433 CG7433-PA, isoform A ) or ( CG7433 CG7433-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: glutamate degradation IV</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.19</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYC3PDEHYDROG__45__RXN" name="Glycerol-3-phosphate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( l(2)k05713 ) or ( l(2)k05713 ) or ( l(2)k05713 ) or ( CG7311 ) or ( CG31169 ) or ( Dhc36C ) or ( CG8046 ) or ( CG31169 ) or ( l(2)k05713 ) or ( CG2137 ) or ( Gpdh ) or ( Gpdh ) or ( CG8046 ) or ( CG3215 ) or ( Gpdh ) or ( CG7311 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lethal (2) k05713 CG8256-PA, isoform A ) or ( lethal (2) k05713 CG8256-PC, isoform C ) or ( lethal (2) k05713 CG8256-PB, isoform B ) or ( CG7311 CG7311-PB, isoform B ) or ( CG31169 CG31169-PA, isoform A ) or ( Dynein heavy chain at 36C CG5526-PA ) or ( CG8046 CG8046-PB, isoform B ) or ( CG31169 CG31169-PB, isoform B ) or ( lethal (2) k05713 CG8256-PD, isoform D ) or ( CG2137 CG2137-PA ) or ( Glycerol 3 phosphate dehydrogenase CG9042-PC, isoform C ) or ( Glycerol 3 phosphate dehydrogenase CG9042-PB, isoform B ) or ( CG8046 CG8046-PA, isoform A ) or ( CG3215 CG3215-PA ) or ( Glycerol 3 phosphate dehydrogenase CG9042-PA, isoform A ) or ( CG7311 CG7311-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINOL__45__8" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCERALDEHYDE__45__DEHYDRO__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9629 ) or ( CG31075 ) or ( Aldh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9629 CG9629-PA ) or ( CG31075 CG31075-PA ) or ( Aldehyde dehydrogenase CG3752-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCERALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTOKIN__45__RXN" name="Galactokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5288 ) or ( CG5288 ) or ( CG5288 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5288 CG5288-PC, isoform C ) or ( CG5288 CG5288-PA, isoform A ) or ( CG5288 CG5288-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__Galactose__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GALACTOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7793" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GlcT-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GlcT-1 CG6437-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.80</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Plant__45__Ceramides__45__I__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Glucosyl__45__Ceramides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMPCYCLOHYDROLASE__45__RXN" name="IMP cyclohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG11089 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG11089 CG11089-PA )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__34__45__RXN" name="Hydroxymethylglutaryl-CoA reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hmgcr ) or ( Hmgcr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxy-3-methylglutaryl coenzyme A reductase ) or ( 3-hydroxy-3-methylglutaryl coenzyme A reductase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="MEVALONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHD__45__RXN" name="Choline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9518 ) or ( CG9514 ) or ( CG9521 ) or ( CG9512 ) or ( CG9522 ) or ( CG9519 ) or ( CG9509 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9518 CG9518-PA ) or ( CG9514 CG9514-PA ) or ( CG9521 CG9521-PA ) or ( CG9512 CG9512-PA ) or ( CG9522 CG9522-PA ) or ( CG9519 CG9519-PA ) or ( CG9509 CG9509-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__901" name="Xanthine dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6045 ) or ( ry )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6045 CG6045-PA ) or ( Xanthine DH )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLPHOSPHATASE__45__RXN" name="Acylphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG10970 ) or ( Acyp2 ) or ( CG11052 ) or ( CG14022 ) or ( CG18371 ) or ( Acyp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG10970 CG10970-PA ) or ( Acylphosphatase 2 CG18505-PA ) or ( CG11052 CG11052-PA ) or ( CG14022 CG14022-PA ) or ( CG18371 CG18371-PA ) or ( Acylphosphatase CG16870-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.7</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Acyl__45__Phosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__239__45__RXN" name="3-&amp;alpha; (17-&amp;beta;)-hydroxysteroid dehydrogenase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( scu )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( scully CG7113-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.239</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TESTOSTERONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ANDROST4ENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPDECARBOX__45__RXN" name="Aspartate 1-decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( b )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( black CG7811-PA )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.11</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R222__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9629 ) or ( CG31075 ) or ( Aldh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9629 CG9629-PA ) or ( CG31075 CG31075-PA ) or ( Aldehyde dehydrogenase CG3752-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__371" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__195" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__15__45__RXN" name="UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5287 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5287 CG5287-PA )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.15</html:p>
<html:p>SIDE: UMP</html:p>
<html:p>SIDE: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
      <speciesReference species="CPD__45__190" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENMETSYN__45__RXN" name="Methionine adenosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( M(2)21AB ) or ( M(2)21AB ) or ( M(2)21AB ) or ( M(2)21AB ) or ( M(2)21AB ) or ( M(2)21AB ) or ( M(2)21AB ) or ( M(2)21AB ) or ( M(2)21AB ) or ( M(2)21AB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Minute (2) 21AB CG2674-PE, isoform E ) or ( Minute (2) 21AB CG2674-PB, isoform B ) or ( Minute (2) 21AB CG2674-PC, isoform C ) or ( Minute (2) 21AB CG2674-PG, isoform G ) or ( Minute (2) 21AB CG2674-PD, isoform D ) or ( Minute (2) 21AB CG2674-PJ, isoform J ) or ( Minute (2) 21AB CG2674-PF, isoform F ) or ( Minute (2) 21AB CG2674-PH, isoform H ) or ( Minute (2) 21AB CG2674-PA, isoform A ) or ( Minute (2) 21AB CG2674-PI, isoform I )</html:p>
<html:p>SUBSYSTEM: methionine degradation I (to homocysteine)</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>SUBSYSTEM: S-adenosylmethionine biosynthesis</html:p>
<html:p>SUBSYSTEM: ethylene biosynthesis from methionine</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNP__45__RXN" name="Purine-nucleoside phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG16758 ) or ( CG16758 ) or ( CG16758 ) or ( CG16758 ) or ( CG18128 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG16758 CG16758-PE, isoform E ) or ( CG16758 CG16758-PD, isoform D ) or ( CG16758 CG16758-PB, isoform B ) or ( CG16758 CG16758-PF, isoform F ) or ( CG18128 CG18128-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Purine__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Bases__124__" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DOPACHROME__45__DELTA__45__ISOMERASE__45__RXN" name="Dopachrome isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yellow-f2 ) or ( yellow-f )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( yellow-f2 CG8063-PA ) or ( yellow f )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DOPACHROME" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_56__45__DIHYDROXYINDOLE__45__2__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7082" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG33090 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG33090 CG33090-PB )</html:p>
<html:p>SUBSYSTEM: DIMBOA-glucoside degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.21</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6562" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="CPD__45__6366" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANIDINOBUTANAMIDE__45__NH3__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7910 ) or ( CG5191 ) or ( CG8839 ) or ( gatA ) or ( CG5191 ) or ( CG5191 ) or ( CG8839 ) or ( CG5191 ) or ( CG5191 ) or ( PGRP-LB ) or ( PGRP-LB ) or ( CG5112 ) or ( CG8839 ) or ( CG7900 ) or ( CG8839 ) or ( PGRP-LB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7910 CG7910-PA ) or ( CG5191 CG5191-PD, isoform D ) or ( CG8839 CG8839-PC, isoform C ) or ( benedict ) or ( CG5191 CG5191-PC, isoform C ) or ( CG5191 CG5191-PA, isoform A ) or ( CG8839 CG8839-PD, isoform D ) or ( CG5191 CG5191-PB, isoform B ) or ( CG5191 CG5191-PE, isoform E ) or ( Peptidoglycan recognition protein LB CG14704-PB, isoform B ) or ( Peptidoglycan recognition protein LB CG14704-PA, isoform A ) or ( CG5112 CG5112-PA ) or ( CG8839 CG8839-PA, isoform A ) or ( CG7900 CG7900-PB ) or ( CG8839 CG8839-PE, isoform E ) or ( Peptidoglycan recognition protein LB CG14704-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: arginine degradation X (arginine monooxygenase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__GUANIDO__45__BUTYRAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__592" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MRNA__45__GUANYLYLTRANSFERASE__45__RXN" name="mRNA guanylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mRNA-capping-enzyme )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mRNA-capping-enzyme CG1810-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.50</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
      <speciesReference species="CPD__45__8630" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8631" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7644" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG4836 ) or ( Sodh-2 ) or ( Sodh-1 ) or ( CG4836 ) or ( CG4836 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG4836 CG4836-PA, isoform A ) or ( Sorbitol dehydrogenase-2 CG4649-PA ) or ( Sorbitol dehydrogenase 1 CG1982-PA ) or ( CG4836 CG4836-PB, isoform B ) or ( CG4836 CG4836-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: sorbitol utilization</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.14</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SORBITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__SYN__45__RXN" name="glutathione synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GS ) or ( CG32495 ) or ( GS ) or ( GS ) or ( CG32495 ) or ( CG32495 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glutathione Synthetase CG6835-PA, isoform A ) or ( CG32495 CG32495-PA, isoform A ) or ( Glutathione Synthetase CG6835-PC, isoform C ) or ( Glutathione Synthetase CG6835-PD, isoform D ) or ( CG32495 CG32495-PB, isoform B ) or ( CG32495 CG32495-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>SUBSYSTEM: glutathione biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GAMMA__45__GLUTAMYLCYSTEINE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPTIDYLAMIDOGLYCOLATE__45__LYASE__45__RXN" name="Peptidylamidoglycolate lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pal ) or ( Pal ) or ( Pal ) or ( CG12130 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase CG5472-PC, isoform C ) or ( Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase CG5472-PB, isoform B ) or ( Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase CG5472-PA, isoform A ) or ( CG12130 CG12130-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__39" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PEPTIDAMIDE__45__CPD" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLAMINE__45__N__45__ACETYLTRANSFERASE__45__RXN" name="Arylamine N-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dat ) or ( Dat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dopamine N acetyltransferase CG3318-PB, isoform B ) or ( Dopamine N acetyltransferase CG3318-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.5</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Amines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYLARYLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7181" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( slgA ) or ( slgA ) or ( slgA ) or ( slgA ) or ( slgA ) or ( slgA ) or ( slgA ) or ( slgA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sluggish A CG1417-PE, isoform E ) or ( sluggish A CG1417-PA, isoform A ) or ( sluggish A CG1417-PH, isoform H ) or ( sluggish A CG1417-PG, isoform G ) or ( sluggish A CG1417-PF, isoform F ) or ( sluggish A CG1417-PD, isoform D ) or ( sluggish A CG1417-PB, isoform B ) or ( sluggish A CG1417-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: proline degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.8</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__224__45__RXN" name="Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-&amp;alpha;-N- acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ext2 ) or ( Ext2 ) or ( ttv )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG8433-PB, isoform B ) or ( CG8433-PA, isoform A ) or ( tout-velu CG10117-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.224</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8599" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8600" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7183" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG33092 ) or ( CG33092 ) or ( CG33092 ) or ( CG7145 ) or ( CG7145 ) or ( CG7145 ) or ( CG33092 ) or ( CG6661 ) or ( CG33092 ) or ( CG33092 ) or ( CG33092 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG33092 CG33092-PD, isoform D ) or ( CG33092 CG33092-PE, isoform E ) or ( CG33092 CG33092-PG, isoform G ) or ( CG7145 CG7145-PD, isoform D ) or ( CG7145 CG7145-PA, isoform A ) or ( CG7145 CG7145-PB, isoform B ) or ( CG33092 CG33092-PA, isoform A ) or ( CG6661 CG6661-PA ) or ( CG33092 CG33092-PB, isoform B ) or ( CG33092 CG33092-PC, isoform C ) or ( CG33092 CG33092-PF, isoform F )</html:p>
<html:p>SUBSYSTEM: proline degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="JUVENILE__45__HORMONE__45__ESTERASE__45__RXN" name="Juvenile-hormone esterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Jhe ) or ( Jhebp29 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Juvenile hormone esterase CG8425-PA ) or ( Juvenile hormone esterase binding protein 29 CG3776-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.59</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__EPOXYTRIDECADIENOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METOH" stoichiometry="1"/>
      <speciesReference species="CPD__45__2021" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__100__45__RXN" name="Protein-S isoprenylcysteine O-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG11268 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG11268 CG11268-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.100</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTEIN__45__C__45__TERMINAL__45__S__45__ETC__45__CYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTEIN__45__C__45__TERMINAL__45__S__45__FARNESYL__45__L__45__CYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__710" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7724 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7724 CG7724-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.145</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__708" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__698" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYSOPHOSPHOLIPASE__45__RXN" name="Lysophospholipase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6567 ) or ( CG8526 ) or ( CG6428 ) or ( CG11029 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6567 CG6567-PB ) or ( CG8526 CG8526-PA ) or ( CG6428 CG6428-PA ) or ( CG11029 CG11029-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__GLYCERO__45__PHOSPHORYLCHOLINE" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENYLALANINE__45__4__45__MONOOXYGENASE__45__RXN" name="Phenylalanine 4-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hn ) or ( Hn ) or ( Trh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Henna CG7399-PA, isoform A ) or ( Henna CG7399-PB, isoform B ) or ( Tryptophan hydroxylase CG9122-PA )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.14.16.1</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHE" stoichiometry="1"/>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TYR" stoichiometry="1"/>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4122" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;alpha;-oxidation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2R__45__HYDROPEROXY__45__FATTY__45__ACIDS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYL__45__COA__45__OXIDASE__45__RXN" name="Acyl-CoA oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Acox57D-d ) or ( Acox57D-p ) or ( CG4586 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-Coenzyme A oxidase at 57D distal CG9709-PA ) or ( acyl-Coenzyme A oxidase at 57D proximal CG9707-PA ) or ( CG4586 CG4586-PA )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation II (core pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.6</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHACYL__45__COA__45__DEHYDROG__45__RXN" name="3-hydroxyacyl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( scu )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( scully CG7113-PA )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation II (core pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.35</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__11__46__1__45__RXN" name="&amp;gamma;-butyrobetaine dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG14630 ) or ( CG5321 ) or ( CG4335 ) or ( CG10814 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG14630 CG14630-PA ) or ( CG5321 CG5321-PA ) or ( CG4335 CG4335-PA ) or ( CG10814 CG10814-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.1</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAMMA__45__BUTYROBETAINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYMIDYLATESYN__45__RXN" name="Thymidylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ts )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ts CG3181-PA )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.45</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: DIHYDROFOLATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XYLULOKIN__45__RXN" name="Xylulokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG3544 ) or ( CG3534 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG3544 CG3544-PA ) or ( CG3534 CG3534-PA )</html:p>
<html:p>SUBSYSTEM: xylitol degradation</html:p>
<html:p>SUBSYSTEM: xylose degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7657" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG18814 ) or ( Adh ) or ( Fdh ) or ( Adh ) or ( Adh ) or ( Adh ) or ( Fbp2 ) or ( Adh ) or ( T3dh ) or ( CG4842 ) or ( Pdh ) or ( Pdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG18814 CG18814-PA ) or ( CG3481-PE, isoform E ) or ( Formaldehyde dehydrogenase CG6598-PA ) or ( CG3481-PC, isoform C ) or ( CG3481-PI, isoform I ) or ( CG3481-PH, isoform H ) or ( Fat body protein 2 CG3763-PA ) or ( CG3481-PF, isoform F ) or ( Type III alcohol dehydrogenase CG3425-PA ) or ( CG4842 CG4842-PA ) or ( Photoreceptor dehydrogenase CG4899-PA, isoform A ) or ( Photoreceptor dehydrogenase CG4899-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: valine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7000" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOBUTANOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG15547 ) or ( nmdyn-D7 ) or ( awd ) or ( nmdyn-D6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG15547 CG15547-PA ) or ( nmdyn-D7 CG8362-PA ) or ( Killer of prune ) or ( nmdyn-D6 CG5310-PA )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BILIVERDIN__45__REDUCTASE__45__RXN" name="Biliverdin reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9471 ) or ( CG9471 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Biliverdin IX-beta reductase ) or ( Biliverdin IX-beta reductase )</html:p>
<html:p>SUBSYSTEM: heme degradation</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.24</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BILIVERDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BILIRUBIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPHINGANINE__45__1__45__PHOSPHATE__45__ALDOLASE__45__RXN" name="Sphinganine-1-phosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sply ) or ( Sply )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Sphingosine-1-phosphate lyase CG8946-PA, isoform A ) or ( Sphingosine-1-phosphate lyase CG8946-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.27</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__649" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PALMITALDEHYDE" stoichiometry="1"/>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DADP_TO_DATP_COF_RXN" name="DADP_TO_DATP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="DADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DATP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOSIDE__45__DIPHOSPHATASE__45__RXN" name="Nucleoside-diphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5276 ) or ( NTPase ) or ( NTPase ) or ( NTPase ) or ( NTPase )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5276 CG5276-PA ) or ( NTPase CG3059-PC, isoform C ) or ( NTPase CG3059-PD, isoform D ) or ( NTPase CG3059-PB, isoform B ) or ( NTPase CG3059-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleotides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ASPARTATE_TO_OXALACETIC_ACID_COF_RXN" name="L-ASPARTATE_TO_OXALACETIC_ACID_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__SULFOGLUCOSAMINE__45__SULFOHYDROLASE__45__RXN" name="N-sulfoglucosamine sulfohydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG14291 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG14291 CG14291-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.10.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__550" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCOSAMINE" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7869" name="&amp;alpha;-1,6-mannosyl-glycoprotein &amp;beta;-1,2-N-acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mgat2 ) or ( Mgat2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Mgat2 CG7921-PA, isoform A ) or ( Mgat2 CG7921-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.143</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSYL__45__ETCETERA__45__MANNOSYL__45__R" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__GLUCOSAMINYL__45__ETCETERA__45__MANNOSYL__45__R" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__18__45__RXN" name="[Myosin light-chain] kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( bt ) or ( Strn-Mlck ) or ( Strn-Mlck ) or ( Strn-Mlck ) or ( Strn-Mlck ) or ( Strn-Mlck ) or ( sls ) or ( Strn-Mlck ) or ( bt ) or ( bt ) or ( bt ) or ( sls ) or ( CG1776 ) or ( Strn-Mlck )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bent CG32019-PE, isoform E ) or ( Stretchin-Mlck CG18255-PC, isoform C ) or ( Stretchin-Mlck CG18255-PF, isoform F ) or ( Stretchin-Mlck CG18255-PB, isoform B ) or ( Stretchin-Mlck CG18255-PG, isoform G ) or ( Stretchin-Mlck CG18255-PD, isoform D ) or ( sallimus CG1915-PA, isoform A ) or ( Stretchin-Mlck CG18255-PE, isoform E ) or ( bent CG32019-PA, isoform A ) or ( bent CG32019-PD, isoform D ) or ( bent CG32019-PC, isoform C ) or ( sallimus CG1915-PC, isoform C ) or ( CG1776 CG1776-PA ) or ( Stretchin-Mlck CG18255-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.18</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8564" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8563" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2624" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mus81 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mus81 CG3026-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.22.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__DNA__45__Combined__45__With__45__Exogenous__45__DNA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Resolution__45__of__45__Recombinational__45__Junction__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__OXOACID__45__COA__45__TRANSFERASE__45__RXN" name="3-oxoacid CoA-transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1140 ) or ( CG1140 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1140 CG1140-PB, isoform B ) or ( CG1140 CG1140-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="A__45__3__45__OXO__45__ACID" stoichiometry="1"/>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="A__45__3__45__OXO__45__ACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1404" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG8129 ) or ( NitFhit ) or ( CG8132 ) or ( CG8129 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG8129 CG8129-PB, isoform B ) or ( Nitrilase and fragile histidine triad fusion protein CG7067-PA ) or ( CG8132 CG8132-PA ) or ( CG8129 CG8129-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.5.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLEYL__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URIDINEKIN__45__RXN" name="Uridine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( l(2)k01209 ) or ( CG6364 ) or ( l(2)k01209 ) or ( Adk1 ) or ( Adk1 ) or ( l(2)k01209 ) or ( l(2)k01209 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lethal (2) k01209 CG4798-PA, isoform A ) or ( CG6364 CG6364-PA ) or ( lethal (2) k01209 CG4798-PB, isoform B ) or ( Adenylate kinase-1 CG17146-PB, isoform B ) or ( Adenylate kinase-1 CG17146-PA, isoform A ) or ( lethal (2) k01209 CG4798-PD, isoform D ) or ( lethal (2) k01209 CG4798-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.48</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP_TO_UTP_COF_RXN" name="UDP_TO_UTP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHITIN__45__SYNTHASE__45__RXN" name="Chitin synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CS-2 ) or ( kkv ) or ( kkv ) or ( kkv )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Chitin synthase 2 CG7464-PA ) or ( Chitin Synthase B ) or ( Chitin Synthase B ) or ( Chitin Synthase B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.16</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHITIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHITIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__AMINO__45__ACID__45__OXIDASE__45__RXN" name="D-amino acid oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG11236 ) or ( CG12338 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG11236 CG11236-PA ) or ( CG12338 CG12338-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBULOSE__45__BISPHOSPHATE__45__CARBOXYLASE__45__RXN" name="Ribulose-bisphosphate carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( y )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( yellow CG3757-PA )</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.39</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__RIBULOSE__45__15__45__P2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="CERAMIDASE__45__YEAST__45__RXN" name="Ceramidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CDase ) or ( CDase ) or ( CDase ) or ( bwa ) or ( CDase ) or ( CDase )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ceramidase CG1471-PB, isoform B ) or ( Ceramidase CG1471-PC, isoform C ) or ( Ceramidase CG1471-PA, isoform A ) or ( brain washing CG13969-PA ) or ( Ceramidase CG1471-PD, isoform D ) or ( Ceramidase CG1471-PE, isoform E )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.23</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Phytoceramides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="PHYTOSPINGOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7668" name="Glycogen (starch) synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6904 ) or ( CG6904 ) or ( CG6904 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6904 CG6904-PC, isoform C ) or ( CG6904 CG6904-PA, isoform A ) or ( CG6904 CG6904-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis II (from UDP-D-Glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.11</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="POLY__45__GLUCOSYLATED__45__GLYCOGENINS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="POLY__45__GLUCOSYLATED__45__GLYCOGENINS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2921" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG2543 ) or ( CG31773 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2543 CG2543-PA ) or ( CG31773 CG31773-PA )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="METHYLENE__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLENE__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7669" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG33138 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG33138 CG33138-PA )</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis II (from UDP-D-Glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="POLY__45__GLUCOSYLATED__45__GLYCOGENINS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Ubiquinones__124___TO___124__Ubiquinols__124___COF_RXN" name="|Ubiquinones|_TO_|Ubiquinols|_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Ubiquinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ubiquinols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTSEMIALDEHYDROG__45__RXN" name="Glutamate-5-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7470 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7470 CG7470-PA )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.41</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GLUTAMATE__45__5__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1461" name="Coproporphyrinogen oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Coprox )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Coproporphyrinogen oxidase CG3433-PA )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPORPHYRINOGEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEME__45__OXYGENASE__45__DECYCLIZING__45__RXN" name="Heme oxygenase (decyclizing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ho )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Heme oxygenase CG14716-PA )</html:p>
<html:p>SUBSYSTEM: heme degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.3</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>SIDE: CARBON__45__MONOXIDE</html:p>
<html:p>SIDE: FE__43__2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BILIVERDINE" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
      <speciesReference species="CARBON__45__MONOXIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSYLCERAMIDASE__45__RXN" name="Glucosylceramidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG31148 ) or ( CG31414 ) or ( CG31413 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG31148 CG31148-PA ) or ( CG31414 CG31414-PB ) or ( CG31413 CG31413-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.45</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCOSYL_CERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="CERAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONATE_TO_UDP_COF_RXN" name="UDP-GLUCURONATE_TO_UDP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFINOALANINE__45__DECARBOXYLASE__45__RXN" name="Sulfinoalanine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5618 ) or ( CG5618 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5618 CG5618-PA, isoform A ) or ( CG5618 CG5618-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: taurine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.29</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__SULFINOALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYPOTAURINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSMANMUT__45__RXN" name="Phosphomannomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pmm45A ) or ( CG10202 ) or ( Pmm45A ) or ( CG10688 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphomannomutase 45A CG8073-PA, isoform A ) or ( CG10202 CG10202-PA ) or ( Phosphomannomutase 45A CG8073-PB, isoform B ) or ( CG10688 CG10688-PA )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MANNOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7781" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( qm ) or ( Fpps )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quemao CG8593-PA ) or ( Farnesyl pyrophosphate synthase CG12389-PA )</html:p>
<html:p>SUBSYSTEM: wighteone and luteone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__3141" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6721" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7780" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( qm ) or ( Fpps )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quemao CG8593-PA ) or ( Farnesyl pyrophosphate synthase CG12389-PA )</html:p>
<html:p>SUBSYSTEM: wighteone and luteone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__3141" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6722" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMIDASE__45__RXN" name="Amidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7910 ) or ( CG5191 ) or ( CG8839 ) or ( gatA ) or ( CG5191 ) or ( CG5191 ) or ( CG8839 ) or ( CG5191 ) or ( CG5191 ) or ( PGRP-LB ) or ( PGRP-LB ) or ( CG5112 ) or ( CG8839 ) or ( CG7900 ) or ( CG8839 ) or ( PGRP-LB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7910 CG7910-PA ) or ( CG5191 CG5191-PD, isoform D ) or ( CG8839 CG8839-PC, isoform C ) or ( benedict ) or ( CG5191 CG5191-PC, isoform C ) or ( CG5191 CG5191-PA, isoform A ) or ( CG8839 CG8839-PD, isoform D ) or ( CG5191 CG5191-PB, isoform B ) or ( CG5191 CG5191-PE, isoform E ) or ( Peptidoglycan recognition protein LB CG14704-PB, isoform B ) or ( Peptidoglycan recognition protein LB CG14704-PA, isoform A ) or ( CG5112 CG5112-PA ) or ( CG8839 CG8839-PA, isoform A ) or ( CG7900 CG7900-PB ) or ( CG8839 CG8839-PE, isoform E ) or ( Peptidoglycan recognition protein LB CG14704-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Monocarboxylic__45__Acid__45__Amides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Monocarboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__37" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9629 ) or ( CG31075 ) or ( Aldh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9629 CG9629-PA ) or ( CG31075 CG31075-PA ) or ( Aldehyde dehydrogenase CG3752-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__30" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__35" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__34" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG4293 ) or ( CG4293 ) or ( CG4293 ) or ( CG4293 ) or ( arg )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG4293 CG4293-PC, isoform C ) or ( CG4293 CG4293-PA, isoform A ) or ( CG4293 CG4293-PD, isoform D ) or ( CG4293 CG4293-PB, isoform B ) or ( arginase CG18104-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CANAVANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="L__45__CANALINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7682" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6045 ) or ( ry )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6045 CG6045-PA ) or ( Xanthine DH )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DESULFOHEPARIN__45__SULFOTRANSFERASE__45__RXN" name="Desulfoheparin sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( sfl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfateless CG8339-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.8</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__DESULFOHEPARIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HEPARIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__127__45__RXN" name="1D-myo-inositol-trisphosphate 3-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG10082 ) or ( CG18854 ) or ( IP3K2 ) or ( CG18854 ) or ( Ipk2 ) or ( CG10082 ) or ( CG18854 ) or ( IP3K2 ) or ( IP3K2 ) or ( IP3K1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG10082 CG10082-PB, isoform B ) or ( CG18854 CG18854-PA, isoform A ) or ( CG34359-PB, isoform B ) or ( CG18854 CG18854-PC, isoform C ) or ( Ipk2 CG13688-PA ) or ( CG10082 CG10082-PA, isoform A ) or ( CG18854 CG18854-PB, isoform B ) or ( CG34359-PA, isoform A ) or ( CG34359-PC, isoform C ) or ( Inositol 1,4,5-triphosphate kinase 1 CG4026-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.127</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__506" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENPRIBOSYLTRAN__45__RXN" name="Adenine phosphoribosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aprt ) or ( Aprt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Adenine phosphoribosyltransferase CG18315-PA, isoform A ) or ( Adenine phosphoribosyltransferase CG18315-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.7</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1603" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: triacylglycerol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__409" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__504" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7873" name="&amp;alpha;-1,3-mannosyl-glycoprotein &amp;beta;-1,4-N-acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG17173 ) or ( CG9384 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG17173 CG17173-PA ) or ( CG9384 CG9384-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.145</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCOSAMINYL__45__ETCETERA__45__MANNOSYL__45__R" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCOSAMINYL__45__14__45__ETCETERA__45__MANNOSYL__45__R" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENE__45__THF_TO_DIHYDROFOLATE_COF_RXN" name="METHYLENE-THF_TO_DIHYDROFOLATE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UGD__45__RXN" name="UDP-glucose 6-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sgl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sugarless CG10072-PA )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.22</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4113" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG18814 ) or ( Adh ) or ( Fdh ) or ( Adh ) or ( Adh ) or ( Adh ) or ( Fbp2 ) or ( Adh ) or ( T3dh ) or ( CG4842 ) or ( Pdh ) or ( Pdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG18814 CG18814-PA ) or ( CG3481-PE, isoform E ) or ( Formaldehyde dehydrogenase CG6598-PA ) or ( CG3481-PC, isoform C ) or ( CG3481-PI, isoform I ) or ( CG3481-PH, isoform H ) or ( Fat body protein 2 CG3763-PA ) or ( CG3481-PF, isoform F ) or ( Type III alcohol dehydrogenase CG3425-PA ) or ( CG4842 CG4842-PA ) or ( Photoreceptor dehydrogenase CG4899-PA, isoform A ) or ( Photoreceptor dehydrogenase CG4899-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDRPHENYLAC__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3O__45__4151" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLINE__45__O__45__ACETYLTRANSFERASE__45__RXN" name="Choline O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Cha ) or ( Cha )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Choline acetyltransferase CG12345-PB, isoform B ) or ( Choline acetyltransferase CG12345-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.6</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYLCHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATEDEHYDR__45__RXN" name="Aconitate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Irp-1A ) or ( CG4706 ) or ( Acon ) or ( Acon ) or ( Irp-1B )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Iron regulatory protein 1A CG4900-PA ) or ( CG4706 CG4706-PA ) or ( Aconitase CG9244-PB, isoform B ) or ( Aconitase CG9244-PC, isoform C ) or ( Iron regulatory protein 1B CG6342-PA )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: itaconate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSEUDOURIDYLATE__45__SYNTHASE__45__RXN" name="Pseudouridylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG4159 ) or ( Nop60B ) or ( RluA-1 ) or ( Nop60B ) or ( RluA-2 ) or ( RluA-1 ) or ( CG3045 ) or ( RluA-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG4159 CG4159-PA ) or ( Nucleolar protein at 60B CG3333-PB, isoform B ) or ( RluA-1 CG31719-PC, isoform C ) or ( Nucleolar protein at 60B CG3333-PA, isoform A ) or ( RluA-2 CG6187-PA ) or ( RluA-1 CG31719-PB, isoform B ) or ( CG3045 CG3045-PA ) or ( RluA-1 CG31719-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.70</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PSEUDOURIDINE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRIACYLGLYCEROL__45__LIPASE__45__RXN" name="Triacylglycerol lipase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG11055 ) or ( CG11055 ) or ( CG5966 ) or ( CG7367 ) or ( CG5932 ) or ( CG6753 ) or ( CG17097 ) or ( Lip2 ) or ( CG6847 ) or ( CG8093 ) or ( CG11406 ) or ( CG11406 ) or ( CG11600 ) or ( CG31872 ) or ( CG3635 ) or ( CG6271 ) or ( bmm ) or ( CG17191 ) or ( CG6277 ) or ( CG31091 ) or ( CG6283 ) or ( CG10357 ) or ( CG6296 ) or ( CG6431 ) or ( CG7329 ) or ( CG33174 ) or ( CG18530 ) or ( CG17192 ) or ( CG6113 ) or ( CG11055 ) or ( CG11598 ) or ( CG33174 ) or ( CG17292 ) or ( CG13282 ) or ( CG6295 ) or ( Lip1 ) or ( CG11608 ) or ( CG2772 ) or ( Lip3 ) or ( CG31089 ) or ( CG31871 ) or ( CG17292 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG11055 CG11055-PA, isoform A ) or ( CG11055 CG11055-PB, isoform B ) or ( CG5966 CG5966-PA ) or ( CG7367 CG7367-PA ) or ( CG5932 CG5932-PA ) or ( CG6753 CG6753-PA ) or ( CG17097 CG17097-PC ) or ( Lipase 2 CG17116-PA ) or ( CG6847 CG6847-PA ) or ( CG8093 CG8093-PA ) or ( CG11406 CG11406-PA, isoform A ) or ( CG11406 CG11406-PB, isoform B ) or ( CG11600 CG11600-PA ) or ( CG31872 CG31872-PA ) or ( CG3635 CG3635-PA ) or ( CG6271 CG6271-PA ) or ( brummer CG5295-PA ) or ( CG17191 CG17191-PA ) or ( CG6277 CG6277-PA ) or ( CG31091 CG31091-PA ) or ( CG6283 CG6283-PA ) or ( CG10357 CG10357-PA ) or ( CG6296 CG6296-PA ) or ( CG6431 CG6431-PA ) or ( CG7329 CG7329-PA ) or ( CG33174 CG33174-PD, isoform D ) or ( CG18530 CG18530-PA ) or ( CG17192 CG17192-PA ) or ( CG6113 CG6113-PA ) or ( CG11055 CG11055-PC, isoform C ) or ( CG11598 CG11598-PB ) or ( CG33174 CG33174-PA, isoform A ) or ( CG17292 CG17292-PA, isoform A ) or ( CG13282 CG13282-PA ) or ( CG6295 CG6295-PA ) or ( Lipase 1 CG7279-PA ) or ( CG11608 CG11608-PA ) or ( CG2772 CG2772-PA ) or ( Lip3 CG8823-PA ) or ( CG31089 CG31089-PA ) or ( CG31871 CG31871-PA ) or ( CG17292 CG17292-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: triacylglycerol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Fatty__45__Acids__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Triacylglycerols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="__124__Diacylglycerides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXNN__45__404" name="indole acetamide hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7910 ) or ( CG5191 ) or ( CG8839 ) or ( gatA ) or ( CG5191 ) or ( CG5191 ) or ( CG8839 ) or ( CG5191 ) or ( CG5191 ) or ( PGRP-LB ) or ( PGRP-LB ) or ( CG5112 ) or ( CG8839 ) or ( CG7900 ) or ( CG8839 ) or ( PGRP-LB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7910 CG7910-PA ) or ( CG5191 CG5191-PD, isoform D ) or ( CG8839 CG8839-PC, isoform C ) or ( benedict ) or ( CG5191 CG5191-PC, isoform C ) or ( CG5191 CG5191-PA, isoform A ) or ( CG8839 CG8839-PD, isoform D ) or ( CG5191 CG5191-PB, isoform B ) or ( CG5191 CG5191-PE, isoform E ) or ( Peptidoglycan recognition protein LB CG14704-PB, isoform B ) or ( Peptidoglycan recognition protein LB CG14704-PA, isoform A ) or ( CG5112 CG5112-PA ) or ( CG8839 CG8839-PA, isoform A ) or ( CG7900 CG7900-PB ) or ( CG8839 CG8839-PE, isoform E ) or ( Peptidoglycan recognition protein LB CG14704-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__237" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATE_TO_L__45__ALPHA__45__ALANINE_COF_RXN" name="PYRUVATE_TO_L-ALPHA-ALANINE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7779" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( qm ) or ( Fpps )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quemao CG8593-PA ) or ( Farnesyl pyrophosphate synthase CG12389-PA )</html:p>
<html:p>SUBSYSTEM: wighteone and luteone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__6641" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6643" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENOYL__45__COA__45__DELTA__45__ISOM__45__RXN" name="Dodecenoyl-CoA &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG4594 ) or ( CG4592 ) or ( CG4598 ) or ( CG13890 ) or ( CG5844 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG4594 CG4594-PA ) or ( CG4592 CG4592-PA ) or ( CG4598 CG4598-PA ) or ( CG13890 CG13890-PA ) or ( CG5844 CG5844-PA )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__DELTA3__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7143" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( qm ) or ( Fpps )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quemao CG8593-PA ) or ( Farnesyl pyrophosphate synthase CG12389-PA )</html:p>
<html:p>SUBSYSTEM: wighteone and luteone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__3141" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6644" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7142" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( qm ) or ( Fpps )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quemao CG8593-PA ) or ( Farnesyl pyrophosphate synthase CG12389-PA )</html:p>
<html:p>SUBSYSTEM: wighteone and luteone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__6641" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6642" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__6__46__1__46__52__45__RXN" name="Diphosphoinositol-polyphosphate diphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aps ) or ( Aps ) or ( Aps )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aps CG6391-PB, isoform B ) or ( Aps CG6391-PA, isoform A ) or ( Aps CG6391-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.52</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Diphospho__45__myo__45__inositol__45__polyphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Myo__45__inositol__45__polyphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LIPOPROTEIN__45__LIPASE__45__RXN" name="Lipoprotein lipase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG4582 ) or ( CG10116 ) or ( CG5665 ) or ( CG1986 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG4582 CG4582-PA ) or ( CG10116 CG10116-PA ) or ( CG5665 CG5665-PA ) or ( CG1986 CG1986-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.34</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Triacylglycerols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__GLN__45__FRUCT__45__6__45__P__45__AMINOTRANS__45__RXN" name="Glucosamine--fructose-6-phosphate aminotransferase (isomerizing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gfat2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glutamine:fructose-6-phosphate aminotransferase 2 CG1345-PA )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.16</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FARNESYLTRANSTRANSFERASE__45__RXN" name="Farnesyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( qm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quemao CG8593-PA )</html:p>
<html:p>SUBSYSTEM: heptaprenyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.29</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENOYL__45__COA__45__HYDRAT__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6984 ) or ( CG6543 ) or ( CG8778 ) or ( CG6543 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6984 CG6984-PA ) or ( CG6543 CG6543-PA, isoform A ) or ( CG8778 CG8778-PA ) or ( CG6543 CG6543-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation II (core pathway)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOHEMEFERROCHELAT__45__RXN" name="Ferrochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ferrochelatase ) or ( ferrochelatase ) or ( ferrochelatase )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ferrochelatase CG2098-PB, isoform B ) or ( ferrochelatase CG2098-PC, isoform C ) or ( ferrochelatase CG2098-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.99.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FE__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOPORPHYRIN_IX" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARAGHYD__45__RXN" name="Asparaginase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5241 ) or ( CG7860 ) or ( SP2637 ) or ( CG8526 ) or ( CG6428 ) or ( SP2637 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5241 CG5241-PA ) or ( CG7860 CG7860-PA ) or ( SP2637 CG5473-PA, isoform A ) or ( CG8526 CG8526-PA ) or ( CG6428 CG6428-PA ) or ( SP2637 CG5473-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: asparagine degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PALMITYL__45__COA_TO_CO__45__A_COF_RXN" name="PALMITYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PALMITYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOHMETRANS__45__RXN" name="glycine hydroxymethyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG3011 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG3011 CG3011-PA )</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.1</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREONINE__45__ALDOLASE__45__RXN" name="Threonine aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG10184 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG10184 CG10184-PA )</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.5</html:p>
<html:p>SIDE: ACETALD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPTOPHAN__45__23__45__DIOXYGENASE__45__RXN" name="Tryptophan 2,3-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( v )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( vermilion CG2155-PA )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.11</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__FORMYLKYNURENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTURIDYLYLTRANS__45__RXN" name="UDP-glucose--hexose-1-phosphate uridylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9232 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9232 CG9232-PA )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__ASPARTATE__45__OXIDASE__45__RXN" name="D-aspartate oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG11236 ) or ( CG12338 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG11236 CG11236-PA ) or ( CG12338 CG12338-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__302" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5781" name="Diacylglycerol cholinephosphotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7149 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7149 CG7149-PA )</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis</html:p>
<html:p>SUBSYSTEM: choline biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.2</html:p>
<html:p>SIDE: DIACYLGLYCEROL</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="CDP__45__CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__11__45__RXN" name="cAMP-dependent protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pka-C3 ) or ( Pka-R2 ) or ( Pka-R1 ) or ( Pka-R2 ) or ( Pka-R1 ) or ( Pka-R2 ) or ( Pka-C1 ) or ( Pka-R2 ) or ( Pka-C1 ) or ( Pka-R2 ) or ( Pka-R1 ) or ( Pka-R1 ) or ( Pka-C1 ) or ( Pka-R1 ) or ( Pka-R1 ) or ( Pka-R1 ) or ( Pka-R1 ) or ( Pka-R1 ) or ( Pka-R1 ) or ( Pka-C3 ) or ( Pka-C2 ) or ( Pka-C2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cAMP-dependent protein kinase 3 CG6117-PB, isoform B ) or ( cAMP-dependent protein kinase R2 CG15862-PE, isoform E ) or ( cAMP-dependent protein kinase R1 CG3263-PF, isoform F ) or ( cAMP-dependent protein kinase R2 CG15862-PD, isoform D ) or ( cAMP-dependent protein kinase R1 CG3263-PC, isoform C ) or ( cAMP-dependent protein kinase R2 CG15862-PC, isoform C ) or ( cAMP-dependent protein kinase 1 CG4379-PB, isoform B ) or ( cAMP-dependent protein kinase R2 CG15862-PB, isoform B ) or ( cAMP-dependent protein kinase 1 CG4379-PC, isoform C ) or ( cAMP-dependent protein kinase R2 CG15862-PA, isoform A ) or ( cAMP-dependent protein kinase R1 CG3263-PI, isoform I ) or ( cAMP-dependent protein kinase R1 CG3263-PH, isoform H ) or ( cAMP-dependent protein kinase 1 CG4379-PA, isoform A ) or ( cAMP-dependent protein kinase R1 CG3263-PG, isoform G ) or ( cAMP-dependent protein kinase R1 CG3263-PA, isoform A ) or ( cAMP-dependent protein kinase R1 CG3263-PB, isoform B ) or ( cAMP-dependent protein kinase R1 CG3263-PD, isoform D ) or ( cAMP-dependent protein kinase R1 CG3263-PE, isoform E ) or ( cAMP-dependent protein kinase R1 CG3263-PJ, isoform J ) or ( cAMP-dependent protein kinase 3 CG6117-PA, isoform A ) or ( cAMP-dependent protein kinase 2 CG12066-PA, isoform A ) or ( cAMP-dependent protein kinase 2 CG12066-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__3__46__9__45__RXN" name="Phosphoenolpyruvate--protein phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ik2 ) or ( ik2 ) or ( Mst36Fb )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ik2 CG2615-PB, isoform B ) or ( ik2 CG2615-PA, isoform A ) or ( Male-specific transcript 36Fb CG31791-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.3.9</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__Histidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__3__45__phospho__45__L__45__histidines__124__" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__PEROXIDASE__45__RXN" name="glutathione peroxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Prx2540-2 ) or ( Prx6005 ) or ( GstS1 ) or ( GstD2 ) or ( GstD8 ) or ( PHGPx ) or ( GstS1 ) or ( GstS1 ) or ( CG15116 ) or ( PHGPx ) or ( PHGPx ) or ( PHGPx ) or ( Prx2540-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Peroxiredoxin 2540 CG11765-PA ) or ( Peroxiredoxin 6005 CG3083-PA ) or ( Glutathione S transferase S1 CG8938-PC, isoform C ) or ( Glutathione S transferase D2 CG4181-PA ) or ( Glutathione S transferase D27 ) or ( PHGPx CG12013-PA, isoform A ) or ( Glutathione S transferase S1 CG8938-PB, isoform B ) or ( Glutathione S transferase S1 CG8938-PA, isoform A ) or ( CG15116 CG15116-PA ) or ( PHGPx CG12013-PB, isoform B ) or ( PHGPx CG12013-PD, isoform D ) or ( PHGPx CG12013-PC, isoform C ) or ( Peroxiredoxin 2540 CG12405-PA )</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions I</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.9</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__22__45__RXN" name="Cyclin-dependent kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Cdk4 ) or ( Cks30A ) or ( Cdk7 ) or ( Cks85A ) or ( Cdk9 ) or ( Cdk8 ) or ( Cdk4 ) or ( Cdk5 ) or ( Cdk4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cyclin-dependent kinase 4 CG5072-PC, isoform C ) or ( Cyclin-dependent kinase subunit 30A CG3738-PA ) or ( Cyclin-dependent kinase 7 CG3319-PA ) or ( Cyclin-dependent kinase subunit 85A CG9790-PA ) or ( Cyclin-dependent kinase 9 CG5179-PA ) or ( Cyclin-dependent kinase 8 CG10572-PA ) or ( Cyclin-dependent kinase 4 CG5072-PB, isoform B ) or ( Cyclin-dependent kinase 5 CG8203-PA ) or ( Cyclin-dependent kinase 4 CG5072-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.22</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXI__45__RXN" name="Lactoylglutathione lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1707 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1707 CG1707-PA )</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.5</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__LACTOYL__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__2__45__HYDROXY__45__ACID__45__OXIDASE__45__RXN" name="(S)-2-hydroxy-acid oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG18003 ) or ( CG18003 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG18003 CG18003-PB, isoform B ) or ( CG18003-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.15</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__S__45__2__45__Hydroxyacids1__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYSACET__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mof )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( males absent on the first CG3025-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.32</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__567" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_CAFFEOYL__45__COA_COF_RXN" name="CO-A_TO_CAFFEOYL-COA_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CAFFEOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCITDEH__45__RXN" name="Isocitrate dehydrogenase (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Idh ) or ( Idh ) or ( Idh ) or ( Idh ) or ( Idh ) or ( Idh ) or ( Idh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Isocitrate dehydrogenase CG7176-PG, isoform G ) or ( Isocitrate dehydrogenase CG7176-PC, isoform C ) or ( Isocitrate dehydrogenase CG7176-PB, isoform B ) or ( Isocitrate dehydrogenase CG7176-PD, isoform D ) or ( Isocitrate dehydrogenase CG7176-PE, isoform E ) or ( Isocitrate dehydrogenase CG7176-PA, isoform A ) or ( Isocitrate dehydrogenase CG7176-PF, isoform F )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.42</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROGENDECARBOX__45__RXN" name="Uroporphyrinogen decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Updo )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Updo CG1818-PA )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.37</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDP__45__4__45__DEHYDRO__45__D__45__RHAMNOSE__45__REDUCTASE__45__RXN" name="GDP-4-dehydro-D-rhamnose reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gmer )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase CG3495-PA )</html:p>
<html:p>SUBSYSTEM: GDP-D-rhamnose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.187</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__353" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLINESTERASE__45__RXN" name="Cholinesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( alpha-Est2 ) or ( alpha-Est9 ) or ( Ace ) or ( alpha-Est10 ) or ( alpha-Est9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-Esterase-2 CG2505-PA ) or ( alpha-Esterase-9 CG1128-PB, isoform B ) or ( Acetylcholine esterase CG17907-PA ) or ( alpha-Esterase-10 CG1131-PA ) or ( alpha-Esterase-9 CG1128-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Acylcholines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLY3KIN__45__RXN" name="Glycerate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9886 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9886 CG9886-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.31</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__56__45__RXN" name="Inositol-1,4,5-trisphosphate 5-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( synj ) or ( CG3573 ) or ( synj ) or ( 5PtaseI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( synaptojanin CG6562-PA, isoform A ) or ( CG3573 CG3573-PA ) or ( synaptojanin CG6562-PB, isoform B ) or ( 5PtaseI CG31107-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.56</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL__45__1__45__4__45__BISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PAPS_TO_PAP_COF_RXN" name="PAPS_TO_PAP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PAPS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1623" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG4753 ) or ( CG4729 ) or ( CG3209 ) or ( CG3812 ) or ( CG15450 ) or ( CG3812 ) or ( fu12 ) or ( CG3209 ) or ( CG4729 ) or ( fu12 ) or ( CG4729 ) or ( CG4729 ) or ( CG4753 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG4753 CG4753-PA, isoform A ) or ( CG4729 CG4729-PD, isoform D ) or ( CG3209 CG3209-PB, isoform B ) or ( CG3812 CG3812-PB, isoform B ) or ( CG15450 CG15450-PA ) or ( CG3812 CG3812-PA, isoform A ) or ( fu12 CG17608-PA, isoform A ) or ( CG3209 CG3209-PA, isoform A ) or ( CG4729 CG4729-PB, isoform B ) or ( fu12 CG17608-PB, isoform B ) or ( CG4729 CG4729-PC, isoform C ) or ( CG4729 CG4729-PA, isoform A ) or ( CG4753 CG4753-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: triacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis II</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.51</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__SN__45__GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYL__45__COA__45__CARBOXYLTRANSFER__45__RXN" name="Acetyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG11198 ) or ( CG11198 ) or ( CG11198 ) or ( CG11198 ) or ( CG17108 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG11198 CG11198-PD, isoform D ) or ( CG11198 CG11198-PC, isoform C ) or ( CG11198 CG11198-PA, isoform A ) or ( CG11198 CG11198-PB, isoform B ) or ( CG17108 CG17108-PA )</html:p>
<html:p>SUBSYSTEM: superpathway of fatty acid biosynthesis initiation (E. coli)</html:p>
<html:p>SUBSYSTEM: fatty acid biosynthesis initiation I</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERVAL__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1673 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1673 CG1673-PA )</html:p>
<html:p>SUBSYSTEM: valine degradation II</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG15547 ) or ( nmdyn-D7 ) or ( awd ) or ( nmdyn-D6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG15547 CG15547-PA ) or ( nmdyn-D7 CG8362-PA ) or ( Killer of prune ) or ( nmdyn-D6 CG5310-PA )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DCTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALCOHOL__45__DEHYDROG__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG18814 ) or ( Adh ) or ( Fdh ) or ( Adh ) or ( Adh ) or ( Adh ) or ( Fbp2 ) or ( Adh ) or ( T3dh ) or ( CG4842 ) or ( Pdh ) or ( Pdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG18814 CG18814-PA ) or ( CG3481-PE, isoform E ) or ( Formaldehyde dehydrogenase CG6598-PA ) or ( CG3481-PC, isoform C ) or ( CG3481-PI, isoform I ) or ( CG3481-PH, isoform H ) or ( Fat body protein 2 CG3763-PA ) or ( CG3481-PF, isoform F ) or ( Type III alcohol dehydrogenase CG3425-PA ) or ( CG4842 CG4842-PA ) or ( Photoreceptor dehydrogenase CG4899-PA, isoform A ) or ( Photoreceptor dehydrogenase CG4899-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDP__45__MANNOSE_TO_GDP_COF_RXN" name="GDP-MANNOSE_TO_GDP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__211__45__RXN" name="Long-chain-3-hydroxyacyl-CoA dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Thiolase ) or ( CG4389 ) or ( CG4389 ) or ( CG4389 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Thiolase CG4581-PA ) or ( CG4389 CG4389-PB, isoform B ) or ( CG4389 CG4389-PC, isoform C ) or ( CG4389 CG4389-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.211</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHATIDATE__45__PHOSPHATASE__45__RXN" name="Phosphatidate phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mod(mdg4) ) or ( mod(mdg4) ) or ( mod(mdg4) ) or ( mod(mdg4) ) or ( CG11437 ) or ( mod(mdg4) ) or ( mod(mdg4) ) or ( mod(mdg4) ) or ( mod(mdg4) ) or ( CG11426 ) or ( mod(mdg4) ) or ( mod(mdg4) ) or ( mod(mdg4) ) or ( mod(mdg4) ) or ( mod(mdg4) ) or ( mod(mdg4) ) or ( mod(mdg4) ) or ( mod(mdg4) ) or ( mod(mdg4) ) or ( wun2 ) or ( CG11438 ) or ( laza ) or ( wun ) or ( mod(mdg4) ) or ( mod(mdg4) ) or ( CG12746 ) or ( mod(mdg4) ) or ( CG12746 ) or ( CG11425 ) or ( mod(mdg4) ) or ( mod(mdg4) ) or ( CG12746 ) or ( CG12746 ) or ( wun )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Enhancer of variegation 93D ) or ( Enhancer of variegation 93D ) or ( Enhancer of variegation 93D ) or ( Enhancer of variegation 93D ) or ( CG11437 CG11437-PA ) or ( Enhancer of variegation 93D ) or ( Enhancer of variegation 93D ) or ( Enhancer of variegation 93D ) or ( Enhancer of variegation 93D ) or ( CG11426 CG11426-PA ) or ( Enhancer of variegation 93D ) or ( Enhancer of variegation 93D ) or ( Enhancer of variegation 93D ) or ( Enhancer of variegation 93D ) or ( Enhancer of variegation 93D ) or ( Enhancer of variegation 93D ) or ( Enhancer of variegation 93D ) or ( Enhancer of variegation 93D ) or ( Enhancer of variegation 93D ) or ( wunen-2 CG8805-PA ) or ( CG11438 CG11438-PA ) or ( lazaro CG11440-PA ) or ( wunen CG8804-PA, isoform A ) or ( Enhancer of variegation 93D ) or ( Enhancer of variegation 93D ) or ( CG12746 CG12746-PB, isoform B ) or ( Enhancer of variegation 93D ) or ( CG12746 CG12746-PD, isoform D ) or ( CG11425 CG11425-PA ) or ( Enhancer of variegation 93D ) or ( Enhancer of variegation 93D ) or ( CG12746 CG12746-PC, isoform C ) or ( CG12746 CG12746-PA, isoform A ) or ( wunen CG8804-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: triacylglycerol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__11__45__RXN" name="CDP-diacylglycerol--inositol 3-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pis ) or ( Pis )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphatidylinositol synthase CG9245-PB, isoform B ) or ( Phosphatidylinositol synthase CG9245-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.11</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="__124__L__45__1__45__phosphatidyl__45__inositols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__317" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1998 ) or ( CG11162 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1998 CG1998-PA ) or ( CG11162 CG11162-PA )</html:p>
<html:p>SUBSYSTEM: zymosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4580" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4702" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARNITINE__45__O__45__PALMITOYLTRANSFERASE__45__RXN" name="Carnitine O-palmitoyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CPTI ) or ( CPTI ) or ( CG2107 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mitochondrial carnitine palmitoyltransferase I CG12891-PA, isoform A ) or ( mitochondrial carnitine palmitoyltransferase I CG12891-PB, isoform B ) or ( CG2107 CG2107-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.21</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: PALMITYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__419" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__GLUCURONID__45__RXN" name="&amp;beta;-glucuronidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG2135 ) or ( CG15117 ) or ( CG15117 ) or ( CG15117 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2135 CG2135-PA ) or ( CG15117 CG15117-PA, isoform A ) or ( CG15117 CG15117-PB, isoform B ) or ( CG15117 CG15117-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.31</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Beta__45__D__45__Glucuronides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCURONATE" stoichiometry="1"/>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROPYRIMIDINASE__45__RXN" name="Dihydropyrimidinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CRMP ) or ( CRMP ) or ( CRMP ) or ( CRMP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Collapsin Response Mediating Protein ) or ( Collapsin Response Mediating Protein ) or ( Collapsin Response Mediating Protein ) or ( Collapsin Response Mediating Protein )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__URACIL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__UREIDO__45__PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYISOBUTYRATE__45__DEHYDROGENASE__45__RXN" name="3-hydroxyisobutyrate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG15093 ) or ( CG15093 ) or ( CG4747 ) or ( CG15093 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG15093 CG15093-PA, isoform A ) or ( CG15093 CG15093-PB, isoform B ) or ( CG4747 CG4747-PA ) or ( CG15093 CG15093-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.31</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CH3__45__MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__316" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1998 ) or ( CG11162 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1998 CG1998-PA ) or ( CG11162 CG11162-PA )</html:p>
<html:p>SUBSYSTEM: zymosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4579" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4580" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BHBDCLOS__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( scu )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( scully CG7113-PA )</html:p>
<html:p>SUBSYSTEM: glutaryl-CoA degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.35</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__32__45__RXN" name="Phosphoenolpyruvate carboxykinase (GTP)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pepck ) or ( CG10924 ) or ( Pepck ) or ( CG10924 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoenolpyruvate carboxykinase CG17725-PB, isoform B ) or ( CG10924 CG10924-PA, isoform A ) or ( Phosphoenolpyruvate carboxykinase CG17725-PA, isoform A ) or ( CG10924 CG10924-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.32</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__315" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1998 ) or ( CG11162 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1998 CG1998-PA ) or ( CG11162 CG11162-PA )</html:p>
<html:p>SUBSYSTEM: zymosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__METHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4579" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARNITINE__45__O__45__ACETYLTRANSFERASE__45__RXN" name="Carnitine O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1041 ) or ( CG1041 ) or ( CG5265 ) or ( CG5122 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1041 CG1041-PB, isoform B ) or ( CG1041 CG1041-PA, isoform A ) or ( CG5265 CG5265-PA ) or ( CG5122 CG5122-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.7</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__ACETYLCARNITINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__42__45__RXN" name="Glycerone-phosphate O-acyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dhap-at )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dihydroxyacetone phosphate acyltransferase CG4625-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.42</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__415" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGINASE__45__RXN" name="Arginase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG4293 ) or ( CG4293 ) or ( CG4293 ) or ( CG4293 ) or ( arg )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG4293 CG4293-PC, isoform C ) or ( CG4293 CG4293-PA, isoform A ) or ( CG4293 CG4293-PD, isoform D ) or ( CG4293 CG4293-PB, isoform B ) or ( arginase CG18104-PA )</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGININE__45__KINASE__45__RXN" name="Arginine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Argk ) or ( Argk ) or ( Argk ) or ( Argk ) or ( Argk ) or ( CG5144 ) or ( CG4546 ) or ( Argk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Arginine kinase CG32031-PF, isoform F ) or ( Arginine kinase CG32031-PC, isoform C ) or ( Arginine kinase CG32031-PB, isoform B ) or ( Arginine kinase CG32031-PA, isoform A ) or ( Arginine kinase CG32031-PE, isoform E ) or ( CG5144 CG5144-PA ) or ( CG4546 CG4546-PA ) or ( Arginine kinase CG32031-PD, isoform D )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.3.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ARGININE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLATECYC__45__RXN" name="Adenylate cyclase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ACXC ) or ( CG32305 ) or ( ACXA ) or ( ACXD ) or ( ACXB ) or ( CG3216 ) or ( CG32158 ) or ( CG32158 ) or ( Gyc-89Da ) or ( CG32158 ) or ( Ac3 ) or ( CG32158 ) or ( CG32301 ) or ( CG32158 ) or ( CG32158 ) or ( Ac13E ) or ( rut ) or ( Ac3 ) or ( Ac3 ) or ( ACXE ) or ( ACXC ) or ( Gyc-89Da ) or ( Ac13E ) or ( Ac78C ) or ( Lap1 ) or ( CG32158 ) or ( CG3216 ) or ( Ac76E )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ACXC CG5983-PB, isoform B ) or ( CG32305 CG32305-PA ) or ( ACXA CG17176-PA ) or ( ACXD CG5712-PA ) or ( ACXB CG17174-PA ) or ( CG3216 CG3216-PB, isoform B ) or ( CG32158 CG32158-PD, isoform D ) or ( CG32158 CG32158-PE, isoform E ) or ( Guanylyl cyclase at 89Da CG14885-PB, isoform B ) or ( CG32158 CG32158-PG, isoform G ) or ( Ac3 CG1506-PC, isoform C ) or ( CG32158 CG32158-PF, isoform F ) or ( CG32301 CG32301-PA ) or ( CG32158 CG32158-PC, isoform C ) or ( CG32158 CG32158-PA, isoform A ) or ( Adenylyl cyclase 35C CG9210-PA, isoform A ) or ( rutabaga CG9533-PA ) or ( Ac3 CG1506-PB, isoform B ) or ( Ac3 CG1506-PA, isoform A ) or ( ACXE CG17178-PA ) or ( ACXC CG5983-PA, isoform A ) or ( Guanylyl cyclase at 89Da CG14885-PC, isoform C ) or ( Adenylyl cyclase 35C CG9210-PB, isoform B ) or ( Adenylyl cyclase 78C CG10564-PA ) or ( Lap1 CG10255-PA ) or ( CG32158 CG32158-PB, isoform B ) or ( CG3216 CG3216-PA, isoform A ) or ( Adenylyl cyclase 76E CG7978-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.6.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CAMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROTATE__45__DEHYDROGENASE__45__RXN" name="Dihydroorotate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( su(r) ) or ( Dhod ) or ( Dhod ) or ( Dhod ) or ( su(r) )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2194-PB, isoform B ) or ( Dihydroorotate dehydrogenase CG9741-PB, isoform B ) or ( Dihydroorotate dehydrogenase CG9741-PA, isoform A ) or ( Dihydroorotate dehydrogenase CG9741-PC, isoform C ) or ( CG2194-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: uridine-5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.11</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXYLATE__45__REDUCTASE__45__NADP__43____45__RXN" name="Glyoxylate reductase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG31674 ) or ( CG31673 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG31674 CG31674-PA ) or ( CG31673 CG31673-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.79</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LCYSDESULF__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG12264 ) or ( Eip55E )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG12264 CG12264-PA ) or ( Eip55E CG5345-PA )</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ASCORBATE__45__OXIDASE__45__RXN" name="L-ascorbate oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5959 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5959 CG5959-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ASCORBATE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DEHYDRO__45__ASCORBATE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__45__45__RXN" name="2-hydroxyacylsphingosine 1-&amp;beta;-galactosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG10170 ) or ( CG17322 ) or ( CG17322 ) or ( Ugt86Dc ) or ( CG17322 ) or ( CG10168 ) or ( CG16732 ) or ( CG17322 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG10170 CG10170-PA ) or ( CG17322 CG17322-PA, isoform A ) or ( CG17322 CG17322-PD, isoform D ) or ( Ugt86Dc CG4739-PA ) or ( CG17322 CG17322-PB, isoform B ) or ( CG10168 CG10168-PA ) or ( CG16732 CG16732-PA ) or ( CG17322 CG17322-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.45</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__2__45__HYDROXYACYLSPHINGOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__BETA__45__D__45__GALACTOSYL__45__2__45__2__45__HYDROXYACYLS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__11__45__RXN" name="1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Plc21C ) or ( Plc21C ) or ( sl ) or ( Plc21C ) or ( norpA ) or ( Plc21C ) or ( norpA ) or ( norpA ) or ( norpA ) or ( Plc21C )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phospholipase C at 21C CG4574-PB, isoform B ) or ( Phospholipase C at 21C CG4574-PF, isoform F ) or ( small wing CG4200-PA ) or ( Phospholipase C at 21C CG4574-PC, isoform C ) or ( no receptor potential A CG3620-PA, isoform A ) or ( Phospholipase C at 21C CG4574-PA, isoform A ) or ( no receptor potential A CG3620-PD, isoform D ) or ( no receptor potential A CG3620-PB, isoform B ) or ( no receptor potential A CG3620-PC, isoform C ) or ( Phospholipase C at 21C CG4574-PD, isoform D )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCITRATE__45__DEHYDROGENASE__45__NAD__43____45__RXN" name="Isocitrate dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG32026 ) or ( l(1)G0156 ) or ( CG3483 ) or ( CG5028 ) or ( l(1)G0156 ) or ( CG5028 ) or ( CG5028 ) or ( CG5028 ) or ( CG5028 ) or ( CG6439 ) or ( CG7755 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG32026 CG32026-PA ) or ( lethal (1) G0156 CG12233-PB, isoform B ) or ( CG3483 CG3483-PA ) or ( CG5028 CG5028-PE, isoform E ) or ( lethal (1) G0156 CG12233-PA, isoform A ) or ( CG5028 CG5028-PB, isoform B ) or ( CG5028 CG5028-PD, isoform D ) or ( CG5028 CG5028-PA, isoform A ) or ( CG5028 CG5028-PC, isoform C ) or ( CG6439 CG6439-PA ) or ( CG7755 CG7755-PA )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.41</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__310" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1998 ) or ( CG11162 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1998 CG1998-PA ) or ( CG11162 CG11162-PA )</html:p>
<html:p>SUBSYSTEM: zymosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_44__45__DIMETHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4575" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__311" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1998 ) or ( CG11162 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1998 CG1998-PA ) or ( CG11162 CG11162-PA )</html:p>
<html:p>SUBSYSTEM: zymosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4575" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4576" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__312" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1998 ) or ( CG11162 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1998 CG1998-PA ) or ( CG11162 CG11162-PA )</html:p>
<html:p>SUBSYSTEM: zymosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4576" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4577" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7920" name="multiple inositol-polyphosphate phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mipp2 ) or ( Mipp1 ) or ( Mipp1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Multiple inositol polyphosphate phosphatase 2 CG4317-PA ) or ( Multiple inositol polyphosphate phosphatase 1 CG4123-PB, isoform B ) or ( Multiple inositol polyphosphate phosphatase 1 CG4123-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.62</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MI__45__HEXAKISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Myo__45__inositol__45__penta__45__kis__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__99__46__1__45__RXN" name="&amp;beta;-galactosamide &amp;alpha;-2,6-sialyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ST6Gal ) or ( ST6Gal )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Sialyltransferase CG4871-PA, isoform A ) or ( Sialyltransferase CG4871-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.99.1</html:p>
<html:p>COFACTOR: CMP__45__N__45__ACETYL__45__NEURAMINATE</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__N__45__ACETYLNEURAMINYL__45__26__45__BETA__45__D__45__GALA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__223__45__RXN" name="Glucuronyl-galactosyl-proteoglycan 4-&amp;alpha;-N- acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( botv )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( brother of tout-velu CG15110-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.223</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8622" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8603" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDOSE1EPIM__45__RXN" name="ALDOSE-1-EPIMERASE" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9008 ) or ( CG10996 ) or ( CG32445 ) or ( CG4988 ) or ( CG10467 ) or ( CG9008 ) or ( CG32444 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9008 CG9008-PB, isoform B ) or ( CG10996 CG10996-PA ) or ( CG32445 CG32445-PA ) or ( CG4988 CG4988-PA ) or ( CG10467 CG10467-PA ) or ( CG9008 CG9008-PA, isoform A ) or ( CG32444 CG32444-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__D__45__GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIB5PISOM__45__RXN" name="Ribose 5-phosphate epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG30410 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG30410 CG30410-PA )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCDEHYDROG__45__RXN" name="Glucose dehydrogenase (pyrroloquinoline-quinone)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9517 ) or ( CG9517 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9517 CG9517-PB, isoform B ) or ( CG9517 CG9517-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.5.2</html:p>
<html:p>COFACTOR: __124__Ubiquinols__124__</html:p>
<html:p>COFACTOR: __124__Ubiquinones__124__</html:p>
<html:p>SIDE: __124__Ubiquinols__124__</html:p>
<html:p>SIDE: __124__Ubiquinones__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IPPISOM__45__RXN" name="Isopentenyl-diphosphate &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5919 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5919 CG5919-PA )</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ETHANOLAMINEPHOSPHOTRANSFERASE__45__RXN" name="Ethanolaminephosphotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6016 ) or ( CG6016 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6016 CG6016-PB, isoform B ) or ( CG6016 CG6016-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: phosphatidylethanolamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.1</html:p>
<html:p>SIDE: DIACYLGLYCEROL</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDP__45__ETHANOLAMINE" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOACETYL__45__COA__45__REDUCTASE__45__RXN" name="Acetoacetyl-CoA reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( scu )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( scully CG7113-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.36</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__15__45__RXN" name="Methylenetetrahydrofolate dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nmdmc ) or ( Nmdmc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD-dependent methylenetetrahydrofolate dehydrogenase CG18466-PB, isoform B ) or ( NAD-dependent methylenetetrahydrofolate dehydrogenase CG18466-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.15</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__P__45__OR__45__NOP_TO_NADH__45__P__45__OR__45__NOP_COF_RXN" name="NAD-P-OR-NOP_TO_NADH-P-OR-NOP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NAD__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADH__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERTRANSAM__45__RXN" name="Phosphoserine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG11899 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG11899 CG11899-PA )</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.52</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__P__45__HYDROXYPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__P__45__SERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDEHYDE__45__REDUCTASE__45__RXN" name="Aldehyde reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6084 ) or ( CG12766 ) or ( CG6083 ) or ( CG9436 ) or ( CG10863 ) or ( CG6084 ) or ( CG10638 ) or ( CG10638 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6084-PB, isoform B ) or ( CG12766 CG12766-PA ) or ( CG6083 CG6083-PA ) or ( CG9436 CG9436-PA ) or ( CG10863 CG10863-PA ) or ( CG6084-PA, isoform A ) or ( CG10638 CG10638-PB, isoform B ) or ( CG10638 CG10638-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.21</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALDITOL" stoichiometry="1"/>
      <speciesReference species="__124__Alditols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALDOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSGLYPHOS__45__RXN" name="Phosphoglycerate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pgk ) or ( CG9961 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoglycerate kinase CG3127-PA ) or ( CG9961 CG9961-PA )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7839" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6984 ) or ( CG6543 ) or ( CG8778 ) or ( CG6543 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6984 CG6984-PA ) or ( CG6543 CG6543-PA, isoform A ) or ( CG8778 CG8778-PA ) or ( CG6543 CG6543-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHONDROITIN__45__6__45__SULFOTRANSFERASE__45__RXN" name="Chondroitin 6-sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9550 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9550 CG9550-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.17</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHONDROITIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHONDROITIN__45__6__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1501" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sPLA2 ) or ( Egfr ) or ( CG10133 ) or ( CG6718 ) or ( SK ) or ( SK ) or ( DNApol-delta ) or ( SK ) or ( rad ) or ( GIIIspla2 ) or ( GXIVsPLA2 ) or ( SK ) or ( CG3009 ) or ( SK ) or ( GXIVsPLA2 ) or ( SK ) or ( Egfr ) or ( SK ) or ( CG6718 ) or ( sPLA2 ) or ( CG6718 ) or ( CG6718 ) or ( CG32741 ) or ( CG30184 ) or ( sPLA2 ) or ( CG7351 ) or ( CG14507 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( secretory Phospholipase A2 CG11124-PB, isoform B ) or ( Epidermal growth factor receptor CG10079-PB, isoform B ) or ( CG10133 CG10133-PA ) or ( CG6718 CG6718-PD, isoform D ) or ( small conductance calcium-activated potassium channel CG10706-PE, isoform E ) or ( small conductance calcium-activated potassium channel CG10706-PG, isoform G ) or ( DNA-polymerase-delta CG5949-PA ) or ( small conductance calcium-activated potassium channel CG10706-PB, isoform B ) or ( radish CG4346-PA ) or ( CG1583 CG1583-PA ) or ( GXIVsPLA2 CG17035-PA, isoform A ) or ( small conductance calcium-activated potassium channel CG10706-PD, isoform D ) or ( CG3009 CG3009-PA ) or ( small conductance calcium-activated potassium channel CG10706-PC, isoform C ) or ( GXIVsPLA2 CG17035-PB, isoform B ) or ( small conductance calcium-activated potassium channel CG10706-PA, isoform A ) or ( Epidermal growth factor receptor CG10079-PA, isoform A ) or ( small conductance calcium-activated potassium channel CG10706-PF, isoform F ) or ( CG6718 CG6718-PA, isoform A ) or ( secretory Phospholipase A2 CG11124-PC, isoform C ) or ( CG6718 CG6718-PB, isoform B ) or ( CG6718 CG6718-PC, isoform C ) or ( CG32741 CG32741-PA ) or ( CG30184 CG30184-PA ) or ( secretory Phospholipase A2 CG11124-PA, isoform A ) or ( CG7351 CG7351-PA ) or ( CG14507 CG14507-PC )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
      <speciesReference species="LINOLENIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7836" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG4594 ) or ( CG4592 ) or ( CG4598 ) or ( CG13890 ) or ( CG5844 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG4594 CG4594-PA ) or ( CG4592 CG4592-PA ) or ( CG4598 CG4598-PA ) or ( CG13890 CG13890-PA ) or ( CG5844 CG5844-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Trans__45__3__45__enoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PGLUCONDEHYDROG__45__RXN" name="Phosphogluconate dehydrogenase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG15093 ) or ( CG15093 ) or ( Pgi ) or ( Pgi ) or ( Pgd ) or ( CG4747 ) or ( CG15093 ) or ( Pgi )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG15093 CG15093-PA, isoform A ) or ( CG15093 CG15093-PB, isoform B ) or ( Phosphoglucose isomerase CG8251-PA, isoform A ) or ( Phosphoglucose isomerase CG8251-PB, isoform B ) or ( Phosphogluconate dehydrogenase CG3724-PA ) or ( CG4747 CG4747-PA ) or ( CG15093 CG15093-PC, isoform C ) or ( Phosphoglucose isomerase CG8251-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.44</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7931" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG4594 ) or ( CG4592 ) or ( CG13890 ) or ( CG4598 ) or ( CG5844 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG4594 CG4594-PA ) or ( CG4592 CG4592-PA ) or ( CG13890 CG13890-PA ) or ( CG4598 CG4598-PA ) or ( CG5844 CG5844-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7221" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7222" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CTPSYN__45__RXN" name="CTP synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6854 ) or ( CG6854 ) or ( CG6854 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6854 CG6854-PB, isoform B ) or ( CG6854 CG6854-PC, isoform C ) or ( CG6854 CG6854-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides interconversion</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7838" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6984 ) or ( CG6543 ) or ( CG8778 ) or ( CG6543 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6984 CG6984-PA ) or ( CG6543 CG6543-PA, isoform A ) or ( CG8778 CG8778-PA ) or ( CG6543 CG6543-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Cis__45__2__45__enoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__SYNTH__45__GLN__45__RXN" name="NAD(+) synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9940 ) or ( CG9940 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9940 CG9940-PA, isoform A ) or ( CG9940 CG9940-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THF_TO_METHYLENE__45__THF_COF_RXN" name="THF_TO_METHYLENE-THF_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMYLTHFGLUSYNTH__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG2543 ) or ( CG31773 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2543 CG2543-PA ) or ( CG31773 CG31773-PA )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINOACYLASE__45__RXN" name="Aminoacylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG17109 ) or ( CG6738 ) or ( CG6733 ) or ( CG6726 ) or ( CG17110 ) or ( CG6465 ) or ( CG6726 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG17109 CG17109-PA ) or ( CG6738 CG6738-PA ) or ( CG6733 CG6733-PA ) or ( CG6726 CG6726-PA, isoform A ) or ( CG17110 CG17110-PA ) or ( CG6465 CG6465-PA ) or ( CG6726 CG6726-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.14</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__N__45__Acylated__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__L__45__Amino__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7001" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG16758 ) or ( CG16758 ) or ( CG16758 ) or ( CG16758 ) or ( CG18128 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG16758 CG16758-PE, isoform E ) or ( CG16758 CG16758-PD, isoform D ) or ( CG16758 CG16758-PB, isoform B ) or ( CG16758 CG16758-PF, isoform F ) or ( CG18128 CG18128-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARSENATE" stoichiometry="1"/>
      <speciesReference species="__124__Purine__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Bases__124__" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1__45__ARSENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7706" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG18814 ) or ( Adh ) or ( Fdh ) or ( Adh ) or ( Adh ) or ( Adh ) or ( Fbp2 ) or ( Adh ) or ( T3dh ) or ( CG4842 ) or ( Pdh ) or ( Pdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG18814 CG18814-PA ) or ( CG3481-PE, isoform E ) or ( Formaldehyde dehydrogenase CG6598-PA ) or ( CG3481-PC, isoform C ) or ( CG3481-PI, isoform I ) or ( CG3481-PH, isoform H ) or ( Fat body protein 2 CG3763-PA ) or ( CG3481-PF, isoform F ) or ( Type III alcohol dehydrogenase CG3425-PA ) or ( CG4842 CG4842-PA ) or ( Photoreceptor dehydrogenase CG4899-PA, isoform A ) or ( Photoreceptor dehydrogenase CG4899-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7036" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7037" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANINE__45__DEAMINASE__45__RXN" name="Guanine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG18143 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG18143 CG18143-PA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.3</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANYL__45__KIN__45__RXN" name="Guanylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sdt ) or ( sdt ) or ( skf ) or ( pyd ) or ( szar ) or ( dlg1 ) or ( pyd ) or ( pyd ) or ( pyd ) or ( szar ) or ( pyd ) or ( pyd ) or ( CG11811 ) or ( dlg1 ) or ( dlg1 ) or ( dlg1 ) or ( Magi ) or ( sdt ) or ( sdt ) or ( szar ) or ( sdt ) or ( Caki ) or ( dlg1 ) or ( Caki ) or ( dlg1 ) or ( Caki ) or ( dlg1 ) or ( dlg1 ) or ( Caki ) or ( sdt ) or ( Caki ) or ( sdt ) or ( dlg1 ) or ( dlg1 ) or ( dlg1 ) or ( dlg1 ) or ( pyd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( stardust CG32717-PB, isoform B ) or ( stardust CG32717-PF, isoform F ) or ( skiff CG30021-PA ) or ( extra verticals ) or ( senz-aria CG9326-PD, isoform D ) or ( discs large 1 CG1725-PD, isoform D ) or ( extra verticals ) or ( extra verticals ) or ( extra verticals ) or ( senz-aria CG9326-PB, isoform B ) or ( extra verticals ) or ( extra verticals ) or ( CG11811 CG11811-PA ) or ( discs large 1 CG1725-PA, isoform A ) or ( discs large 1 CG1725-PG, isoform G ) or ( discs large 1 CG1725-PE, isoform E ) or ( Magi CG30388-PA ) or ( stardust CG32717-PA, isoform A ) or ( stardust CG32717-PH, isoform H ) or ( senz-aria CG9326-PC, isoform C ) or ( stardust CG32717-PG, isoform G ) or ( Calcium/calmodulin-dependent protein kinase CG6703-PE, isoform E ) or ( discs large 1 CG1725-PK, isoform K ) or ( Calcium/calmodulin-dependent protein kinase CG6703-PA, isoform A ) or ( discs large 1 CG1725-PF, isoform F ) or ( Calcium/calmodulin-dependent protein kinase CG6703-PD, isoform D ) or ( discs large 1 CG1725-PI, isoform I ) or ( discs large 1 CG1725-PJ, isoform J ) or ( Calcium/calmodulin-dependent protein kinase CG6703-PB, isoform B ) or ( stardust CG32717-PD, isoform D ) or ( Calcium/calmodulin-dependent protein kinase CG6703-PC, isoform C ) or ( stardust CG32717-PE, isoform E ) or ( discs large 1 CG1725-PH, isoform H ) or ( discs large 1 CG1725-PC, isoform C ) or ( discs large 1 CG1725-PB, isoform B ) or ( discs large 1 CG1725-PL, isoform L ) or ( extra verticals )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5442" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aldehyde dehydrogenase type III CG11140-PD, isoform D ) or ( Aldehyde dehydrogenase type III CG11140-PA, isoform A ) or ( Aldehyde dehydrogenase type III CG11140-PH, isoform H ) or ( Aldehyde dehydrogenase type III CG11140-PE, isoform E ) or ( Aldehyde dehydrogenase type III CG11140-PC, isoform C ) or ( Aldehyde dehydrogenase type III CG11140-PI, isoform I ) or ( Aldehyde dehydrogenase type III CG11140-PB, isoform B ) or ( Aldehyde dehydrogenase type III CG11140-PG, isoform G ) or ( Aldehyde dehydrogenase type III CG11140-PF, isoform F )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXIDIZED__45__ACCEPTOR" stoichiometry="1"/>
      <speciesReference species="_3__45__INDOLYLGLYCOLALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE__45__3__45__GLYCOLATE" stoichiometry="1"/>
      <speciesReference species="__124__Donor__45__H2__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__154__45__RXN" name="Phosphatidylinositol-4-phosphate 3-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pi3K92E ) or ( Pi3K68D ) or ( Pi3K68D ) or ( Pi3K92E ) or ( Pi3K68D )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PI 3-kinase ) or ( Phosphotidylinositol 3 kinase 68D CG11621-PB, isoform B ) or ( Phosphotidylinositol 3 kinase 68D CG11621-PA, isoform A ) or ( PI 3-kinase ) or ( Phosphotidylinositol 3 kinase 68D CG11621-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.154</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1108" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__PHOSPHATIDYL__45__1D__45__MYO__45__INOSITOL__45__34__45__BISPH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7700" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG18814 ) or ( Adh ) or ( Fdh ) or ( Adh ) or ( Adh ) or ( Adh ) or ( Fbp2 ) or ( Adh ) or ( T3dh ) or ( CG4842 ) or ( Pdh ) or ( Pdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG18814 CG18814-PA ) or ( CG3481-PE, isoform E ) or ( Formaldehyde dehydrogenase CG6598-PA ) or ( CG3481-PC, isoform C ) or ( CG3481-PI, isoform I ) or ( CG3481-PH, isoform H ) or ( Fat body protein 2 CG3763-PA ) or ( CG3481-PF, isoform F ) or ( Type III alcohol dehydrogenase CG3425-PA ) or ( CG4842 CG4842-PA ) or ( Photoreceptor dehydrogenase CG4899-PA, isoform A ) or ( Photoreceptor dehydrogenase CG4899-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: phenylethanol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7035" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5445" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aldehyde dehydrogenase type III CG11140-PD, isoform D ) or ( Aldehyde dehydrogenase type III CG11140-PA, isoform A ) or ( Aldehyde dehydrogenase type III CG11140-PH, isoform H ) or ( Aldehyde dehydrogenase type III CG11140-PE, isoform E ) or ( Aldehyde dehydrogenase type III CG11140-PC, isoform C ) or ( Aldehyde dehydrogenase type III CG11140-PI, isoform I ) or ( Aldehyde dehydrogenase type III CG11140-PB, isoform B ) or ( Aldehyde dehydrogenase type III CG11140-PG, isoform G ) or ( Aldehyde dehydrogenase type III CG11140-PF, isoform F )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__INDOLEGLYOXAL" stoichiometry="1"/>
      <speciesReference species="OXIDIZED__45__ACCEPTOR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE__45__3__45__GLYOXYLATE" stoichiometry="1"/>
      <speciesReference species="__124__Donor__45__H2__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Acceptor__124___TO___124__Donor__45__H2__124___COF_RXN" name="|Acceptor|_TO_|Donor-H2|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Acceptor__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Donor__45__H2__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URATE__45__OXIDASE__45__RXN" name="Urate oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Uro )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Urate oxidase CG7171-PA )</html:p>
<html:p>SUBSYSTEM: urate degradation to allantoin</html:p>
<html:p>PROTEIN_CLASS: 1.7.3.3</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__HYDROXYISOURATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__72__45__RXN" name="Methylsterol monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1998 ) or ( CG11162 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1998 CG1998-PA ) or ( CG11162 CG11162-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_44__45__DIMETHYL__45__5ALPHA__45__CHOLEST__45__7__45__EN__45__3BET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5847" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMP__45__DEHYDROG__45__RXN" name="IMP dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ras ) or ( ras ) or ( ras )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( raspberry CG1799-PA, isoform A ) or ( raspberry CG1799-PC, isoform C ) or ( raspberry CG1799-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.205</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XMPXAN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG11126 ) or ( CG11883 ) or ( CG1961 ) or ( CG11883 ) or ( CG4827 ) or ( CG11883 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG32549 CG32549-PE, isoform E ) or ( CG32549 CG32549-PA, isoform A ) or ( CG32549 CG32549-PB, isoform B ) or ( CG32549 CG32549-PC, isoform C ) or ( CG32549 CG32549-PF, isoform F ) or ( CG32549 CG32549-PD, isoform D ) or ( CG11126 CG11126-PA ) or ( CG11883 CG11883-PA, isoform A ) or ( CG1961 CG1961-PA ) or ( CG11883 CG11883-PC, isoform C ) or ( CG4827 CG4827-PA ) or ( CG11883 CG11883-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MMUM__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG10623 ) or ( CG10621 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG10623 CG10623-PA ) or ( CG10621 CG10621-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.10</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="CPD__45__397" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__2__46__31__45__RXN" name="NAD(P)(+)--arginine ADP-ribosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Arf51F ) or ( Arf51F ) or ( Arf51F ) or ( Arf51F ) or ( Arf51F ) or ( Arf102F )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP ribosylation factor 51F CG8156-PD, isoform D ) or ( ADP ribosylation factor 51F CG8156-PE, isoform E ) or ( ADP ribosylation factor 51F CG8156-PB, isoform B ) or ( ADP ribosylation factor 51F CG8156-PC, isoform C ) or ( ADP ribosylation factor 51F CG8156-PA, isoform A ) or ( ADP ribosylation factor 102F CG11027-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.31</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAD__45__P__45__OR__45__NOP" stoichiometry="1"/>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__557" stoichiometry="1"/>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOTIDASE__45__RXN" name="Nucleotidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG2862 ) or ( CG2862 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2862 CG2862-PA, isoform A ) or ( CG2862 CG2862-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.31</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nucleotides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7908" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pcd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pterin-4a-carbinolamine dehydratase CG1963-PA )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.96</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHITIN__45__DEACETYLASE__45__RXN" name="Chitin deacetylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LCBP1 ) or ( LCBP1 ) or ( serp ) or ( LCBP1 ) or ( LCBP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( LDLa domain containing chitin binding protein 1 CG8756-PC, isoform C ) or ( LDLa domain containing chitin binding protein 1 CG8756-PB, isoform B ) or ( serpentine CG32209-PB ) or ( LDLa domain containing chitin binding protein 1 CG8756-PA, isoform A ) or ( LDLa domain containing chitin binding protein 1 CG8756-PD, isoform D )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.41</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_14__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYLN1" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="__124__Chitosan__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__200" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__9__46__3__45__RXN" name="Selenide,water dikinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SelD ) or ( SelD ) or ( Sps2 ) or ( Sps2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( selenide,water dikinase CG8553-PA, isoform A ) or ( selenide,water dikinase CG8553-PB, isoform B ) or ( Selenophosphate synthetase 2 CG5025-PB, isoform B ) or ( Selenophosphate synthetase 2 CG5025-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: selenocysteine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.9.3</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__678" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SEPO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__45__PHOSPHOFRUCTO__45__2__45__KINASE__45__RXN" name="6-phosphofructo-2-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pfrx ) or ( Pfrx ) or ( Pfrx ) or ( Pfrx ) or ( Pfrx ) or ( Pfrx ) or ( Pfrx ) or ( Pfrx )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphofructo-2-kinase CG3400-PH, isoform H ) or ( 6-phosphofructo-2-kinase CG3400-PD, isoform D ) or ( 6-phosphofructo-2-kinase CG3400-PE, isoform E ) or ( 6-phosphofructo-2-kinase CG3400-PF, isoform F ) or ( 6-phosphofructo-2-kinase CG3400-PI, isoform I ) or ( 6-phosphofructo-2-kinase CG3400-PA, isoform A ) or ( 6-phosphofructo-2-kinase CG3400-PB, isoform B ) or ( 6-phosphofructo-2-kinase CG3400-PG, isoform G )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.105</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__535" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__145__45__RXN" name="3-&amp;beta;-hydroxy-&amp;delta;(5)-steroid dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7724 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7724 CG7724-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.145</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__3b__45__hydroxy__45__D5__45__steroids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__3__45__oxo__45__D5__45__steroids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__20__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6188 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6188 CG6188-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.20</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__1__46__47__45__RXN" name="2-acetyl-1-alkylglycerophosphocholine esterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Paf-AHalpha ) or ( Paf-AHalpha )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Platelet-activating factor acetylhydrolase alpha CG8962-PB, isoform B ) or ( Platelet-activating factor acetylhydrolase alpha CG8962-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.47</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alkyl__45__acetyl__45__glycero__45__phosphocholines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="__124__1__45__Alkyl__45__sn__45__glycero__45__3__45__phosphocholines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3PGAREARR__45__RXN" name="Phosphoglycerate mutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7059 ) or ( Pglym78 ) or ( Pglym78 ) or ( CG7059 ) or ( Pglym87 ) or ( Pglym78 ) or ( CG7059 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7059 CG7059-PC, isoform C ) or ( Phosphoglyceromutase CG1721-PB, isoform B ) or ( Phosphoglyceromutase CG1721-PC, isoform C ) or ( CG7059 CG7059-PA, isoform A ) or ( Pglym87 CG17645-PA ) or ( Phosphoglyceromutase CG1721-PA, isoform A ) or ( CG7059 CG7059-PD, isoform D )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DGDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG15547 ) or ( nmdyn-D7 ) or ( awd ) or ( nmdyn-D6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG15547 CG15547-PA ) or ( nmdyn-D7 CG8362-PA ) or ( Killer of prune ) or ( nmdyn-D6 CG5310-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TREHALOSEPHOSPHA__45__RXN" name="Trehalose-phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5177 ) or ( CG5171 ) or ( CG5171 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5177 CG5177-PA ) or ( CG5171 CG5171-PB, isoform B ) or ( CG5171 CG5171-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis II</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis III</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.12</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URACIL__45__PRIBOSYLTRANS__45__RXN" name="Uracil phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5537 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5537 CG5537-PA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.9</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45__C__45__PALMITOYLTRANSFERASE__45__RXN" name="Serine C-palmitoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Spt-I ) or ( lace ) or ( Spt-I ) or ( Spt-I )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Serine palmitoyltransferase subunit I CG4016-PC, isoform C ) or ( lace CG4162-PA ) or ( Serine palmitoyltransferase subunit I CG4016-PA, isoform A ) or ( Serine palmitoyltransferase subunit I CG4016-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: ceramide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.50</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: PALMITYL__45__COA</html:p>
<html:p>SIDE: SER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEHYDROSPHINGANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOPHOSPHORYL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GlyP ) or ( CG16965 ) or ( GlyP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glycogen phosphorylase CG7254-PA, isoform A ) or ( CG16965 CG16965-PA ) or ( Glycogen phosphorylase CG7254-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="CPD0__45__971" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__8__46__5__46__1__45__RXN" name="Glutathione dehydrogenase (ascorbate)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6673 ) or ( CG6673 ) or ( CG6776 ) or ( CG6662 ) or ( se )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6673 CG6673-PB, isoform B ) or ( CG6673 CG6673-PA, isoform A ) or ( CG6776 CG6776-PA ) or ( CG6662 CG6662-PA ) or ( CG6781-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.8.5.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DEHYDRO__45__ASCORBATE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7710" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG33138 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG33138 CG33138-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Starch__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7711" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG16935 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG16935 CG16935-PA )</html:p>
<html:p>SUBSYSTEM: very long chain fatty acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.38</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMP__45__DEAMINASE__45__RXN" name="AMP deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG32626 ) or ( CG32626 ) or ( CG32626 ) or ( CG32626 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG32626 CG32626-PB, isoform B ) or ( CG32626 CG32626-PC, isoform C ) or ( CG32626 CG32626-PA, isoform A ) or ( CG32626 CG32626-PD, isoform D )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCMP__45__DEAMINASE__45__RXN" name="dCMP deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6951 ) or ( CG6951 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6951 CG6951-PA, isoform A ) or ( CG6951 CG6951-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__NUCLEOTID__45__RXN" name="5&apos;-nucleotidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG2862 ) or ( CG11883 ) or ( CG11883 ) or ( CG1961 ) or ( CG2862 ) or ( CG4827 ) or ( CG11883 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG11126 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2862 CG2862-PA, isoform A ) or ( CG11883 CG11883-PA, isoform A ) or ( CG11883 CG11883-PC, isoform C ) or ( CG1961 CG1961-PA ) or ( CG2862 CG2862-PB, isoform B ) or ( CG4827 CG4827-PA ) or ( CG11883 CG11883-PB, isoform B ) or ( CG32549 CG32549-PE, isoform E ) or ( CG32549 CG32549-PA, isoform A ) or ( CG32549 CG32549-PB, isoform B ) or ( CG32549 CG32549-PF, isoform F ) or ( CG32549 CG32549-PC, isoform C ) or ( CG32549 CG32549-PD, isoform D ) or ( CG11126 CG11126-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNPISOM__45__RXN" name="Mannose-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG8417 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG8417 CG8417-PA )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: D-mannose degradation</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>SUBSYSTEM: mannitol degradation II</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__11__46__2__45__RXN" name="Procollagen-proline,2-oxoglutarate-4-dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG4174 ) or ( PH4alphaNE3 ) or ( CG4174 ) or ( CG34345 ) or ( CG32199 ) or ( PH4alphaNE2 ) or ( CG32201 ) or ( PH4alphaSG2 ) or ( CG31524 ) or ( PH4alphaPV ) or ( PH4alphaMP ) or ( CG18749 ) or ( CG31016 ) or ( CG9698 ) or ( CG11828 ) or ( CG31524 ) or ( CG15539 ) or ( CG4174 ) or ( PH4alphaNE1 ) or ( CG15539 ) or ( PH4alphaEFB ) or ( PH4alphaSG1 ) or ( PH4alphaSG2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG4174-PA, isoform A ) or ( prolyl-4-hydroxylase-alpha NE3 CG31017-PA ) or ( CG4174-PB, isoform B ) or ( CG34345-PA ) or ( CG32199 CG32199-PA ) or ( prolyl-4-hydroxylase-alpha NE2 CG9720-PA ) or ( CG32201 CG32201-PA ) or ( prolyl-4-hydroxylase-alpha SG2 CG1546-PA, isoform A ) or ( CG31524 CG31524-PB, isoform B ) or ( prolyl-4-hydroxylase-alpha PV CG31015-PA ) or ( alpha subunit ) or ( CG18749-PB, isoform B ) or ( CG31016 CG31016-PA ) or ( CG9698 CG9698-PA ) or ( CG11828 CG11828-PA ) or ( CG31524 CG31524-PA, isoform A ) or ( CG15539 CG15539-PB, isoform B ) or ( CG4174-PC, isoform C ) or ( prolyl-4-hydroxylase-alpha NE1 CG9728-PA ) or ( CG15539 CG15539-PA, isoform A ) or ( prolyl-4-hydroxylase-alpha EFB CG31022-PA ) or ( prolyl-4-hydroxylase-alpha SG1 CG31014-PA ) or ( prolyl-4-hydroxylase-alpha SG2 CG1546-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.2</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROCOLLAGEN__45__L__45__PROLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6321" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__8__46__2__46__23__45__RXN" name="Heparin-glucosamine 3-O-sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hs3st-A ) or ( Hs3st-B )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Heparan sulfate 3-O sulfotransferase-A CG33147-PA ) or ( Heparan sulfate 3-O sulfotransferase-B CG7890-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.23</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HEPARIN__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HEPARIN__45__GLUCOSAMINE__45__3__45__O__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__REDUCT__45__NADPH__45__RXN" name="Glutathione reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Trxr-1 ) or ( Trxr-1 ) or ( Trxr-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Thioredoxin reductase-1 CG2151-PA, isoform A ) or ( Thioredoxin reductase-1 CG2151-PB, isoform B ) or ( Thioredoxin reductase-1 CG2151-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions II</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions I</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7919" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG4365 ) or ( CG4365 ) or ( CG4365 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG4365 CG4365-PC, isoform C ) or ( CG4365 CG4365-PA, isoform A ) or ( CG4365 CG4365-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__hydroxyacyl__45__glutathiones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="__124__2__45__Hydroxy__45__carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7913" name="Cytidylate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dak1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dak1 CG6092-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DCDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNITHINE__45____45__OXO__45__ACID__45__AMINOTRANSFERASE__45__RXN" name="Ornithine--oxo-acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Oat ) or ( CG8745 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ornithine aminotransferase precursor CG8782-PA ) or ( CG8745 CG8745-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.13</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
      <speciesReference species="__124__Amino__45__Acids__45__20__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__4__46__1__45__RXN" name="Vitamin-K-epoxide reductase (warfarin-sensitive)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Vkor )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Vitamin-K epoxide reductase CG33544-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.4.1</html:p>
<html:p>COFACTOR: DITHIOTHREITOL</html:p>
<html:p>COFACTOR: OXIDIZED__45__DITHIOTHREITOL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__METHYL__45__3__45__PHYTYL__45__14__45__NAPHTHOQUINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_23__45__EPOXY__45__23__45__DIHYDRO__45__2__45__METHYL__45__14__45__NAPHTHOQ" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPONTPRO__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: proline biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5841" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG11126 ) or ( CG11883 ) or ( CG1961 ) or ( CG11883 ) or ( CG4827 ) or ( CG11883 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG32549 CG32549-PE, isoform E ) or ( CG32549 CG32549-PA, isoform A ) or ( CG32549 CG32549-PB, isoform B ) or ( CG32549 CG32549-PC, isoform C ) or ( CG32549 CG32549-PF, isoform F ) or ( CG32549 CG32549-PD, isoform D ) or ( CG11126 CG11126-PA ) or ( CG11883 CG11883-PA, isoform A ) or ( CG1961 CG1961-PA ) or ( CG11883 CG11883-PC, isoform C ) or ( CG4827 CG4827-PA ) or ( CG11883 CG11883-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway II</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINAMIDE_RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__133__45__RXN" name="Xylosylprotein 4-&amp;beta;-galactosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( beta4GalT7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-4-galactosyltransferase 7 CG11780-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.133</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8590" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8202" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MEVALONATE__45__KINASE__45__RXN" name="Mevalonate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG33671 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG33671-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.36</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MEVALONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__499" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIACYLGLYKIN__45__RXN" name="Diacylglycerol kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dgkepsilon ) or ( CG16708 ) or ( CG31140 ) or ( Dgk ) or ( CG34384 ) or ( rdgA ) or ( Dgk ) or ( Dgk ) or ( CG16708 ) or ( rdgA ) or ( rdgA ) or ( Sk1 ) or ( CG31140 ) or ( CG31140 ) or ( CG31140 ) or ( Sk2 ) or ( Dgk ) or ( Sk1 ) or ( CG31140 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Diacyl glycerol kinase epsilon CG8657-PA ) or ( CG16708 CG16708-PB, isoform B ) or ( CG31140 CG31140-PE, isoform E ) or ( CG34361-PG, isoform G ) or ( CG14462 ) or ( CG34344-PB, isoform B ) or ( CG34361-PE, isoform E ) or ( CG34361-PF, isoform F ) or ( CG16708 CG16708-PA, isoform A ) or ( CG34344-PC, isoform C ) or ( CG34344-PA, isoform A ) or ( Sphingosine kinase 1 CG1747-PA, isoform A ) or ( CG31140 CG31140-PB, isoform B ) or ( CG31140 CG31140-PC, isoform C ) or ( CG31140 CG31140-PD, isoform D ) or ( Sphingosine kinase 2 CG32484-PA ) or ( CG34361-PC, isoform C ) or ( Sphingosine kinase 1 CG1747-PB, isoform B ) or ( CG31140 CG31140-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.107</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45____45__PYRUVATE__45__AMINOTRANSFERASE__45__RXN" name="Serine--pyruvate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Spat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Serine pyruvate aminotransferase CG3926-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.51</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHMETHYLBILANESYN__45__RXN" name="Hydroxymethylbilane synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( l(3)02640 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lethal (3) 02640 CG9165-PA )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.61</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PORPHOBILINOGEN" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXYMETHYLBILANE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DURIDKI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dnk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxyribonucleoside kinase CG5452-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYURIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIOSULFATE__45__SULFURTRANSFERASE__45__RXN" name="Thiosulfate sulfurtransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG12279 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG12279 CG12279-PA )</html:p>
<html:p>SUBSYSTEM: thiosulfate disproportionation III (rhodanese)</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.1</html:p>
<html:p>SIDE: HCN</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S2O3" stoichiometry="1"/>
      <speciesReference species="HCN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="HSCN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__62__45__RXN" name="mRNA (2&apos;-O-methyladenosine-N6-)-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5933 ) or ( CG7818 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5933 CG5933-PA ) or ( CG7818 CG7818-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.62</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8628" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8629" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLCROTONYL__45__COA__45__CARBOXYLASE__45__RXN" name="Methylcrotonyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG2118 ) or ( CG3267 ) or ( CG2118 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2118 CG2118-PB, isoform B ) or ( CG3267 CG3267-PA ) or ( CG2118 CG2118-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__3__45__METHYL__45__GLUTACONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PFRUCTPHOS__45__RXN" name="6-phosphofructokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pfk ) or ( Pfk ) or ( Pfk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphofructokinase CG4001-PC, isoform C ) or ( Phosphofructokinase CG4001-PB, isoform B ) or ( Phosphofructokinase CG4001-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALCOHOL__45__DEHYDROG__45__GENERIC__45__RXN" name="alcohol dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG18814 ) or ( Adh ) or ( Fdh ) or ( Adh ) or ( Adh ) or ( Adh ) or ( Fbp2 ) or ( Adh ) or ( T3dh ) or ( CG4842 ) or ( Pdh ) or ( Pdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG18814 CG18814-PA ) or ( CG3481-PE, isoform E ) or ( Formaldehyde dehydrogenase CG6598-PA ) or ( CG3481-PC, isoform C ) or ( CG3481-PI, isoform I ) or ( CG3481-PH, isoform H ) or ( Fat body protein 2 CG3763-PA ) or ( CG3481-PF, isoform F ) or ( Type III alcohol dehydrogenase CG3425-PA ) or ( CG4842 CG4842-PA ) or ( Photoreceptor dehydrogenase CG4899-PA, isoform A ) or ( Photoreceptor dehydrogenase CG4899-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__45__Or__45__Ketones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACID__45__PHOSPHATASE__45__RXN" name="Acid phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG15385 ) or ( CG9449 ) or ( primo-2 ) or ( primo-1 ) or ( CG1637 ) or ( Acph-1 ) or ( CG1637 ) or ( CG9452 ) or ( CG6656 ) or ( CG1637 ) or ( CG9451 ) or ( Mipp2 ) or ( Mipp1 ) or ( Mipp1 ) or ( Acph-1 ) or ( CG9449 ) or ( primo-1 ) or ( primo-1 ) or ( primo-2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG15385 CG15385-PA ) or ( CG9449 CG9449-PC, isoform C ) or ( CG33747-PC, isoform C ) or ( CG33748-PC, isoform C ) or ( CG1637 CG1637-PC, isoform C ) or ( Acid phosphatase 1 CG7899-PB, isoform B ) or ( CG1637 CG1637-PA, isoform A ) or ( CG9452 CG9452-PA ) or ( CG6656 CG6656-PA ) or ( CG1637 CG1637-PB, isoform B ) or ( CG9451 CG9451-PA ) or ( Multiple inositol polyphosphate phosphatase 2 CG4317-PA ) or ( Multiple inositol polyphosphate phosphatase 1 CG4123-PB, isoform B ) or ( Multiple inositol polyphosphate phosphatase 1 CG4123-PA, isoform A ) or ( Acid phosphatase 1 CG7899-PA, isoform A ) or ( CG9449 CG9449-PB, isoform B ) or ( CG33748-PA, isoform A ) or ( CG33748-PB, isoform B ) or ( CG33747-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Orthophosphoric__45__Monoesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTATHIONINE__45__BETA__45__SYNTHASE__45__RXN" name="Cystathionine &amp;beta;-synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1753 ) or ( CG1753 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1753 CG1753-PA, isoform A ) or ( CG1753 CG1753-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: homocysteine degradation</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.22</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__150__45__RXN" name="N-acetyllactosaminide &amp;beta;-1,6-N-acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9171 ) or ( CG9171 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9171 CG9171-PA, isoform A ) or ( CG9171 CG9171-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.150</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINYL__45__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__16__45__ETCETERA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__152__45__RXN" name="Inositol-hexakisphosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG10082 ) or ( CG10082 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG10082 CG10082-PB, isoform B ) or ( CG10082 CG10082-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MI__45__HEXAKISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__DIPHOSPHO__45__1D__45__MYO__45__INOSITOL__45__12346P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__SULFINOALANINE__45__AMINOTRANSFERASE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Got1 ) or ( Got2 ) or ( Got1 ) or ( Got2 ) or ( Got2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glutamate oxaloacetate transaminase 1 CG8430-PB, isoform B ) or ( Glutamate oxaloacetate transaminase 2 CG4233-PC, isoform C ) or ( Glutamate oxaloacetate transaminase 1 CG8430-PA, isoform A ) or ( Glutamate oxaloacetate transaminase 2 CG4233-PB, isoform B ) or ( Glutamate oxaloacetate transaminase 2 CG4233-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.1</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__SULFINOALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__SULFINYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__151__45__RXN" name="Inositol-polyphosphate multikinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ipk2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ipk2 CG13688-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.151</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL__45__1456__45__TETRAKISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSCHOL__45__RXN" name="Phospholipase D" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pld ) or ( Pld ) or ( Pld ) or ( Pld ) or ( Pld )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phospholipase D CG12110-PE, isoform E ) or ( Phospholipase D CG12110-PA, isoform A ) or ( Phospholipase D CG12110-PD, isoform D ) or ( Phospholipase D CG12110-PC, isoform C ) or ( Phospholipase D CG12110-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>SUBSYSTEM: choline biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENOSYLMETHIONINE_TO_ADENOSYL__45__HOMO__45__CYS_COF_RXN" name="S-ADENOSYLMETHIONINE_TO_ADENOSYL-HOMO-CYS_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__17__45__RXN" name="3&apos;,5&apos;-cyclic-nucleotide phosphodiesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( dnc ) or ( dnc ) or ( CG31757 ) or ( dnc ) or ( dnc ) or ( Pde6 ) or ( dnc ) or ( dnc ) or ( dnc ) or ( dnc ) or ( dnc ) or ( dnc ) or ( dnc ) or ( dnc ) or ( dnc ) or ( dnc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dunce CG32498-PC, isoform C ) or ( dunce CG32498-PA, isoform A ) or ( CG31757 CG31757-PA ) or ( dunce CG32498-PM, isoform M ) or ( dunce CG32498-PL, isoform L ) or ( Phosphodiesterase 6 CG8279-PA ) or ( dunce CG32498-PK, isoform K ) or ( dunce CG32498-PD, isoform D ) or ( dunce CG32498-PI, isoform I ) or ( dunce CG32498-PJ, isoform J ) or ( dunce CG32498-PB, isoform B ) or ( dunce CG32498-PN, isoform N ) or ( dunce CG32498-PO, isoform O ) or ( dunce CG32498-PG, isoform G ) or ( dunce CG32498-PE, isoform E ) or ( dunce CG32498-PF, isoform F )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.17</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Cyclic__45__3__45__5__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NUC__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTOTHENATE__45__KIN__45__RXN" name="Pantothenate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fbl ) or ( fbl ) or ( fbl ) or ( fbl ) or ( fbl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fumble CG5725-PB, isoform B ) or ( fumble CG5725-PC, isoform C ) or ( fumble CG5725-PD, isoform D ) or ( fumble CG5725-PA, isoform A ) or ( fumble CG5725-PE, isoform E )</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.33</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__P__45__PANTOTHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__OXOPROLINASE__45__ATP__45__HYDROLYSING__45__RXN" name="5-oxoprolinase (ATP-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG4752 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG4752 CG4752-PA )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__OXOPROLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOGEN__45__BRANCH__45__RXN" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG33138 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG33138 CG33138-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AICARTRANSFORM__45__RXN" name="Phosphoribosylaminoimidazolecarboxamide formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG11089 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG11089 CG11089-PA )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.3</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>COFACTOR: _10__45__FORMYL__45__THF</html:p>
<html:p>SIDE: THF</html:p>
<html:p>SIDE: _10__45__FORMYL__45__THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AICAR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENODEAMIN__45__RXN" name="Adenosine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Adgf-C ) or ( Adar ) or ( Adgf-E ) or ( Adgf-D ) or ( Ada ) or ( Adgf-B ) or ( Adar ) or ( Adgf-A ) or ( Adgf-A ) or ( Adar )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Adenosine deaminase-related growth factor C CG9345-PA ) or ( Adenosine deaminase acting on RNA CG12598-PC, isoform C ) or ( Adenosine deaminase-related growth factor E CG10143-PA ) or ( Adenosine deaminase-related growth factor D CG9621-PA ) or ( Adenosine deaminase CG11994-PA ) or ( Adenosine deaminase-related growth factor B CG5998-PA ) or ( Adenosine deaminase acting on RNA CG12598-PB, isoform B ) or ( Adenosine deaminase-related growth factor A CG5992-PB, isoform B ) or ( Adenosine deaminase-related growth factor A CG5992-PA, isoform A ) or ( Adenosine deaminase acting on RNA CG12598-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLACYLYLCOA__45__HYDROXY__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6984 ) or ( CG6543 ) or ( CG8778 ) or ( CG6543 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6984 CG6984-PA ) or ( CG6543 CG6543-PA, isoform A ) or ( CG8778 CG8778-PA ) or ( CG6543 CG6543-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHACRYLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__57__45__RXN" name="Inositol-1,4-bisphosphate 1-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ipp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Inositol polyphosphate 1-phosphatase CG3028-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.57</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__4__45__BISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__MYO__45__INOSITOL__45__4__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2TRANSKETO__45__RXN" name="Transketolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5103 ) or ( CG8036 ) or ( CG8036 ) or ( CG8036 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5103 CG5103-PA ) or ( CG8036 CG8036-PD, isoform D ) or ( CG8036 CG8036-PB, isoform B ) or ( CG8036 CG8036-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1685" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hex-A ) or ( Hex-t1 ) or ( Hex-t2 ) or ( Hex-A ) or ( Hex-C )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Hexokinase A CG3001-PB, isoform B ) or ( Hex-t1 CG33102-PA ) or ( Hex-t2 CG32849-PA ) or ( Hexokinase A CG3001-PA, isoform A ) or ( Hexokinase C CG8094-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5822" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG15385 ) or ( CG9449 ) or ( primo-2 ) or ( primo-1 ) or ( CG1637 ) or ( Acph-1 ) or ( CG1637 ) or ( CG9452 ) or ( CG6656 ) or ( CG1637 ) or ( CG9451 ) or ( Mipp2 ) or ( Mipp1 ) or ( Mipp1 ) or ( Acph-1 ) or ( CG9449 ) or ( primo-1 ) or ( primo-1 ) or ( primo-2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG15385 CG15385-PA ) or ( CG9449 CG9449-PC, isoform C ) or ( CG33747-PC, isoform C ) or ( CG33748-PC, isoform C ) or ( CG1637 CG1637-PC, isoform C ) or ( Acid phosphatase 1 CG7899-PB, isoform B ) or ( CG1637 CG1637-PA, isoform A ) or ( CG9452 CG9452-PA ) or ( CG6656 CG6656-PA ) or ( CG1637 CG1637-PB, isoform B ) or ( CG9451 CG9451-PA ) or ( Multiple inositol polyphosphate phosphatase 2 CG4317-PA ) or ( Multiple inositol polyphosphate phosphatase 1 CG4123-PB, isoform B ) or ( Multiple inositol polyphosphate phosphatase 1 CG4123-PA, isoform A ) or ( Acid phosphatase 1 CG7899-PA, isoform A ) or ( CG9449 CG9449-PB, isoform B ) or ( CG33748-PA, isoform A ) or ( CG33748-PB, isoform B ) or ( CG33747-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway II</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIMETHYLARGININASE__45__RXN" name="Dimethylargininase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1764 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1764 CG1764-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__596" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMETHYLAMINE" stoichiometry="1"/>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYPYRROLINEDEH__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG33092 ) or ( CG33092 ) or ( CG33092 ) or ( CG7145 ) or ( CG7145 ) or ( CG7145 ) or ( CG33092 ) or ( CG6661 ) or ( CG33092 ) or ( CG33092 ) or ( CG33092 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG33092 CG33092-PD, isoform D ) or ( CG33092 CG33092-PE, isoform E ) or ( CG33092 CG33092-PG, isoform G ) or ( CG7145 CG7145-PD, isoform D ) or ( CG7145 CG7145-PA, isoform A ) or ( CG7145 CG7145-PB, isoform B ) or ( CG33092 CG33092-PA, isoform A ) or ( CG6661 CG6661-PA ) or ( CG33092 CG33092-PB, isoform B ) or ( CG33092 CG33092-PC, isoform C ) or ( CG33092 CG33092-PF, isoform F )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyproline degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRROLINE__45__HYDROXY__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ERYTHRO__45__4__45__HYDROXY__45__GLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLDIALKYLPHOSPHATASE__45__RXN" name="Aryldialkylphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG18473 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG18473 CG18473-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Dialkyl__45__Phosphate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
      <speciesReference species="__124__Dialkyl__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5581" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aldehyde dehydrogenase type III CG11140-PD, isoform D ) or ( Aldehyde dehydrogenase type III CG11140-PA, isoform A ) or ( Aldehyde dehydrogenase type III CG11140-PH, isoform H ) or ( Aldehyde dehydrogenase type III CG11140-PE, isoform E ) or ( Aldehyde dehydrogenase type III CG11140-PC, isoform C ) or ( Aldehyde dehydrogenase type III CG11140-PI, isoform I ) or ( Aldehyde dehydrogenase type III CG11140-PB, isoform B ) or ( Aldehyde dehydrogenase type III CG11140-PG, isoform G ) or ( Aldehyde dehydrogenase type III CG11140-PF, isoform F )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.5</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE_ACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATE__45__CARBOXYLASE__45__RXN" name="Pyruvate carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1516 ) or ( CG1516 ) or ( CG1516 ) or ( CG1516 ) or ( CG1516 ) or ( CG1516 ) or ( CG1516 ) or ( CG1516 ) or ( CG1516 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1516 CG1516-PE, isoform E ) or ( CG1516 CG1516-PL, isoform L ) or ( CG1516 CG1516-PD, isoform D ) or ( CG1516 CG1516-PA, isoform A ) or ( CG1516 CG1516-PB, isoform B ) or ( CG1516 CG1516-PI, isoform I ) or ( CG1516 CG1516-PJ, isoform J ) or ( CG1516 CG1516-PK, isoform K ) or ( CG1516 CG1516-PG, isoform G )</html:p>
<html:p>SUBSYSTEM: itaconate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPGLUCEPIM__45__RXN" name="UDP-glucose 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG12030 ) or ( CG4988 ) or ( CG5955 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG12030 CG12030-PA ) or ( CG4988 CG4988-PA ) or ( CG5955 CG5955-PA )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LTAA__45__RXN" name="L-allo-threonine aldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG10184 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG10184 CG10184-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ALLO__45__THREONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALKAPHOSPHA__45__RXN" name="Alkaline phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG3292 ) or ( CG5361 ) or ( CG3264 ) or ( CG8147 ) or ( Aph-4 ) or ( Aph-4 ) or ( CG5150 ) or ( CG16771 ) or ( CG1809 ) or ( CG10592 ) or ( CG5656 ) or ( CG10827 ) or ( CG8105 ) or ( CG3290 ) or ( CG8147 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG3292 CG3292-PA ) or ( CG5361 CG5361-PA ) or ( CG3264 CG3264-PA ) or ( CG8147 CG8147-PB, isoform B ) or ( Alkaline phosphatase ) or ( Alkaline phosphatase ) or ( CG5150 CG5150-PA ) or ( CG16771 CG16771-PA ) or ( CG1809 CG1809-PA ) or ( CG10592 CG10592-PA ) or ( CG5656 CG5656-PA ) or ( CG10827 CG10827-PA ) or ( CG8105 CG8105-PA ) or ( CG3290 CG3290-PA ) or ( CG8147 CG8147-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Orthophosphoric__45__Monoesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXNI__45__2" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1140 ) or ( CG1140 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1140 CG1140-PB, isoform B ) or ( CG1140 CG1140-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__1__46__99__46__4__45__RXN" name="&amp;alpha;-methylacyl-CoA racemase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9319 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9319 CG9319-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.99.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__2__45__METHYLACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="R__45__2__45__METHYLACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PGLUCONOLACT__45__RXN" name="6-phosphogluconolactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG17333 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG17333 CG17333-PA )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.31</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R542__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG18814 ) or ( Adh ) or ( Fdh ) or ( Adh ) or ( Adh ) or ( Adh ) or ( Fbp2 ) or ( Adh ) or ( T3dh ) or ( CG4842 ) or ( Pdh ) or ( Pdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG18814 CG18814-PA ) or ( CG3481-PE, isoform E ) or ( Formaldehyde dehydrogenase CG6598-PA ) or ( CG3481-PC, isoform C ) or ( CG3481-PI, isoform I ) or ( CG3481-PH, isoform H ) or ( Fat body protein 2 CG3763-PA ) or ( CG3481-PF, isoform F ) or ( Type III alcohol dehydrogenase CG3425-PA ) or ( CG4842 CG4842-PA ) or ( Photoreceptor dehydrogenase CG4899-PA, isoform A ) or ( Photoreceptor dehydrogenase CG4899-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__863" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__864" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ECDYSONE__45__20__45__MONOOXYGENASE__45__RXN" name="Ecdysone 20-monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( shd ) or ( shd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( shade CG13478-PB, isoform B ) or ( shade CG13478-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.22</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ECDYSONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__276" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R81__45__RXN" name="Hexokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hex-A ) or ( Hex-t1 ) or ( Hex-t2 ) or ( Hex-A ) or ( Hex-C )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Hexokinase A CG3001-PB, isoform B ) or ( Hex-t1 CG33102-PA ) or ( Hex-t2 CG32849-PA ) or ( Hexokinase A CG3001-PA, isoform A ) or ( Hexokinase C CG8094-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRNA__45__PSEUDOURIDINE__45__SYNTHASE__45__I__45__RXN" name="tRNA-pseudouridine synthase I" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RluA-1 ) or ( RluA-2 ) or ( RluA-1 ) or ( RluA-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( RluA-1 CG31719-PC, isoform C ) or ( RluA-2 CG6187-PA ) or ( RluA-1 CG31719-PB, isoform B ) or ( RluA-1 CG31719-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8538" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8537" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIACYLGLYCEROL__45__O__45__ACYLTRANSFERASE__45__RXN" name="Diacylglycerol O-acyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mdy ) or ( mdy ) or ( mdy ) or ( mdy )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( midway CG31991-PB, isoform B ) or ( midway CG31991-PA, isoform A ) or ( midway CG31991-PD, isoform D ) or ( midway CG31991-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: triacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: wax esters biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.20</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Triacylglycerols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_ADP_COF_RXN" name="ATP_TO_ADP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLUCISOM__45__RXN" name="Glucose-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pgi ) or ( Pgi ) or ( Pgi )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoglucose isomerase CG8251-PA, isoform A ) or ( Phosphoglucose isomerase CG8251-PB, isoform B ) or ( Phosphoglucose isomerase CG8251-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__97__45__RXN" name="Glycylpeptide N-tetradecanoyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Nmt ) or ( CG3585 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-myristoyl transferase CG7436-PA ) or ( CG3585 CG3585-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.97</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TETRADECANOYL__45__COA" stoichiometry="1"/>
      <speciesReference species="GLYCYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__TETRADECANOYLGLYCYL__45__PEPTIDE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8748" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG3292 ) or ( CG5361 ) or ( CG3264 ) or ( CG8147 ) or ( Aph-4 ) or ( Aph-4 ) or ( CG5150 ) or ( CG16771 ) or ( CG1809 ) or ( CG10592 ) or ( CG5656 ) or ( CG10827 ) or ( CG8105 ) or ( CG3290 ) or ( CG8147 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG3292 CG3292-PA ) or ( CG5361 CG5361-PA ) or ( CG3264 CG3264-PA ) or ( CG8147 CG8147-PB, isoform B ) or ( Alkaline phosphatase ) or ( Alkaline phosphatase ) or ( CG5150 CG5150-PA ) or ( CG16771 CG16771-PA ) or ( CG1809 CG1809-PA ) or ( CG10592 CG10592-PA ) or ( CG5656 CG5656-PA ) or ( CG10827 CG10827-PA ) or ( CG8105 CG8105-PA ) or ( CG3290 CG3290-PA ) or ( CG8147 CG8147-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: diethylphosphate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ETOH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8978" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTKIN__45__RXN" name="Glutamate 5-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7470 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7470 CG7470-PA )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYKI__45__RXN" name="Thymidine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dnk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxyribonucleoside kinase CG5452-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THYMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CITSYN__45__RXN" name="Citrate (si)-synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( kdn ) or ( kdn ) or ( CG14740 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG3861-PA, isoform A ) or ( CG3861-PB, isoform B ) or ( CG14740 CG14740-PA )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: itaconate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.1</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2102" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG11913 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG11913 CG11913-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.11</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Methylesterified__45__homogalacturonan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METOH" stoichiometry="1"/>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__galacturonosyl__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8743" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG18473 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG18473 CG18473-PA )</html:p>
<html:p>SUBSYSTEM: methyl parathion degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8973" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
      <speciesReference species="CPD__45__8974" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBULP3EPIM__45__RXN" name="ribulose phosphate 3-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG30499 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG30499 CG30499-PA )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8746" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG18473 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG18473 CG18473-PA )</html:p>
<html:p>SUBSYSTEM: paraoxon degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PARAOXON" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
      <speciesReference species="DIETHYLPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8747" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pde8 ) or ( Pde9 ) or ( Pde8 ) or ( Pde8 ) or ( Pde8 ) or ( Pde8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphodiesterase 8 CG5411-PA, isoform A ) or ( Phosphodiesterase 9 CG32648-PA ) or ( Phosphodiesterase 8 CG5411-PB, isoform B ) or ( Phosphodiesterase 8 CG5411-PC, isoform C ) or ( Phosphodiesterase 8 CG5411-PE, isoform E ) or ( Phosphodiesterase 8 CG5411-PD, isoform D )</html:p>
<html:p>SUBSYSTEM: diethylphosphate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ETOH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIETHYLPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETOH" stoichiometry="1"/>
      <speciesReference species="CPD__45__8978" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__5__46__1__45__RXN" name="Nitrilase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG8129 ) or ( NitFhit ) or ( CG8132 ) or ( CG8129 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG8129 CG8129-PB, isoform B ) or ( Nitrilase and fragile histidine triad fusion protein CG7067-PA ) or ( CG8132 CG8132-PA ) or ( CG8129 CG8129-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.5.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nitriles__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__201__45__RXN" name="7-&amp;beta;-hydroxysteroid dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( scu )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( scully CG7113-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.201</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__7__45__Beta__45__Hydroxysteroids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__7__45__Oxosteroids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVINKIN__45__RXN" name="Riboflavin kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG2846 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2846 CG2846-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.26</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOFLAVIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Fatty__45__Acyl__45__CoA__124___TO_CO__45__A_COF_RXN" name="|Fatty-Acyl-CoA|_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="F16BDEPHOS__45__RXN" name="Fructose-bisphosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fbp ) or ( fbp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructose-1,6-bisphosphatase CG31692-PA, isoform A ) or ( fructose-1,6-bisphosphatase CG31692-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__20__45__RXN" name="Methylenetetrahydrofolate reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7560 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7560 CG7560-PA )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.20</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CERAMIDE__45__GLUCOSYLTRANSFERASE__45__RXN" name="Ceramide glucosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GlcT-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GlcT-1 CG6437-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.80</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCOSYL_CERAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDPMANDEHYDRA__45__RXN" name="GDP-mannose 4,6-dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gmd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-mannose 4,6-dehydratase CG8890-PA )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis I (from GDP-D-mannose)</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-&amp;alpha;-D-perosamine biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-D-rhamnose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.47</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOHEXOKINASE__45__RXN" name="Ketohexokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7551 ) or ( CG7335 ) or ( CG12289 ) or ( CG7328 ) or ( CG12289 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7551 CG7551-PB ) or ( CG7335 CG7335-PA ) or ( CG12289 CG12289-PB, isoform B ) or ( CG7328 CG7328-PA ) or ( CG12289 CG12289-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TYROSINE__45__3__45__MONOOXYGENASE__45__RXN" name="Tyrosine 3-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ple ) or ( ple )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pale CG10118-PB, isoform B ) or ( pale CG10118-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: betalain biosynthesis (to betalamic acid)</html:p>
<html:p>SUBSYSTEM: catecholamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.16.2</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CPD__45__5881</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="1"/>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATEHYDR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Irp-1A ) or ( CG4706 ) or ( Acon ) or ( Acon ) or ( Irp-1B )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Iron regulatory protein 1A CG4900-PA ) or ( CG4706 CG4706-PA ) or ( Aconitase CG9244-PB, isoform B ) or ( Aconitase CG9244-PC, isoform C ) or ( Iron regulatory protein 1B CG6342-PA )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTALDDEHYDROG__45__RXN" name="Lactaldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh-III ) or ( CG9629 ) or ( Aldh-III ) or ( CG31075 ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aldehyde dehydrogenase type III CG11140-PD, isoform D ) or ( CG9629 CG9629-PA ) or ( Aldehyde dehydrogenase type III CG11140-PA, isoform A ) or ( CG31075 CG31075-PA ) or ( Aldehyde dehydrogenase type III CG11140-PH, isoform H ) or ( Aldehyde dehydrogenase type III CG11140-PE, isoform E ) or ( Aldehyde dehydrogenase type III CG11140-PC, isoform C ) or ( Aldehyde dehydrogenase CG3752-PA ) or ( Aldehyde dehydrogenase type III CG11140-PB, isoform B ) or ( Aldehyde dehydrogenase type III CG11140-PI, isoform I ) or ( Aldehyde dehydrogenase type III CG11140-PG, isoform G ) or ( Aldehyde dehydrogenase type III CG11140-PF, isoform F )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.22</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE_TO_UDP_COF_RXN" name="UDP-N-ACETYL-D-GLUCOSAMINE_TO_UDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTEIN__45__KINASE__45__RXN" name="Protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ste:CG33245 ) or ( CkIIbeta ) or ( CkIIbeta ) or ( CkIIbeta ) or ( CkIIalpha ) or ( CkIIbeta ) or ( CkIIbeta ) or ( CkIIbeta2 ) or ( Ste:CG33243 ) or ( PKD ) or ( PKD ) or ( PKD ) or ( Ih ) or ( Ih ) or ( Ih ) or ( Pka-C2 ) or ( Pka-R2 ) or ( Pka-R1 ) or ( Pka-R2 ) or ( for ) or ( Pka-C1 ) or ( Pka-R2 ) or ( Ste:CG33246 ) or ( Pka-C1 ) or ( Pka-R2 ) or ( Pka-R2 ) or ( Ssl ) or ( Ste12DOR ) or ( Pka-C1 ) or ( Ste:CG33247 ) or ( CkIIalpha ) or ( CkIIalpha ) or ( Pkcdelta ) or ( Ssl ) or ( Ste:CG33244 ) or ( Pkg21D ) or ( Ste:CG33241 ) or ( for ) or ( for ) or ( for ) or ( for ) or ( for ) or ( for ) or ( Ih ) or ( for ) or ( for ) or ( for ) or ( Ste:CG33237 ) or ( Ste:CG33238 ) or ( PKD ) or ( Ste:CG33242 ) or ( Pka-C3 ) or ( Pka-C2 ) or ( Pka-C3 ) or ( Epac ) or ( Pka-R1 ) or ( Ste:CG33239 ) or ( Pka-R1 ) or ( Pka-R1 ) or ( Pka-R1 ) or ( Pka-R1 ) or ( Pka-R1 ) or ( Pka-R1 ) or ( Pka-R1 ) or ( Pka-R1 ) or ( CkIIbeta ) or ( Ste:CG33236 ) or ( Epac ) or ( Ste:CG33240 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ste:CG33245 CG33245-PA ) or ( Casein kinase II beta subunit CG15224-PA, isoform A ) or ( Casein kinase II beta subunit CG15224-PB, isoform B ) or ( Casein kinase II beta subunit CG15224-PE, isoform E ) or ( Casein kinase II alpha subunit CG17520-PC, isoform C ) or ( Casein kinase II beta subunit CG15224-PC, isoform C ) or ( Casein kinase II beta subunit CG15224-PF, isoform F ) or ( Casein kinase II beta2 subunit CG8914-PA ) or ( Ste:CG33243 CG33243-PA ) or ( Protein Kinase D CG7125-PA, isoform A ) or ( Protein Kinase D CG7125-PB, isoform B ) or ( Protein Kinase D CG7125-PC, isoform C ) or ( I[[h]] channel CG8585-PC, isoform C ) or ( I[[h]] channel CG8585-PE, isoform E ) or ( I[[h]] channel CG8585-PB, isoform B ) or ( cAMP-dependent protein kinase 2 CG12066-PB, isoform B ) or ( cAMP-dependent protein kinase R2 CG15862-PE, isoform E ) or ( cAMP-dependent protein kinase R1 CG3263-PF, isoform F ) or ( cAMP-dependent protein kinase R2 CG15862-PD, isoform D ) or ( foraging CG10033-PF, isoform F ) or ( cAMP-dependent protein kinase 1 CG4379-PB, isoform B ) or ( cAMP-dependent protein kinase R2 CG15862-PC, isoform C ) or ( Ste:CG33246 CG33246-PA ) or ( cAMP-dependent protein kinase 1 CG4379-PC, isoform C ) or ( cAMP-dependent protein kinase R2 CG15862-PB, isoform B ) or ( cAMP-dependent protein kinase R2 CG15862-PA, isoform A ) or ( Suppressor of Stellate-like CG13591-PB, isoform B ) or ( Stellate 12D orphon CG32616-PA ) or ( cAMP-dependent protein kinase 1 CG4379-PA, isoform A ) or ( Ste:CG33247 CG33247-PA ) or ( Casein kinase II alpha subunit CG17520-PB, isoform B ) or ( Casein kinase II alpha subunit CG17520-PA, isoform A ) or ( Protein kinase C delta CG10524-PA ) or ( Suppressor of Stellate-like CG13591-PA, isoform A ) or ( Ste:CG33244 CG33244-PA ) or ( cGMP-dependent protein kinase 21D CG3324-PA ) or ( Ste:CG33241 CG33241-PA ) or ( foraging CG10033-PJ, isoform J ) or ( foraging CG10033-PE, isoform E ) or ( foraging CG10033-PD, isoform D ) or ( foraging CG10033-PC, isoform C ) or ( foraging CG10033-PG, isoform G ) or ( foraging CG10033-PH, isoform H ) or ( I[[h]] channel CG8585-PD, isoform D ) or ( foraging CG10033-PI, isoform I ) or ( foraging CG10033-PA, isoform A ) or ( foraging CG10033-PB, isoform B ) or ( Ste:CG33237 CG33237-PA ) or ( Ste:CG33238 CG33238-PA ) or ( Protein Kinase D CG7125-PD, isoform D ) or ( Ste:CG33242 CG33242-PA ) or ( cAMP-dependent protein kinase 3 CG6117-PA, isoform A ) or ( cAMP-dependent protein kinase 2 CG12066-PA, isoform A ) or ( cAMP-dependent protein kinase 3 CG6117-PB, isoform B ) or ( Epac CG34392-PC, isoform C ) or ( cAMP-dependent protein kinase R1 CG3263-PC, isoform C ) or ( Ste:CG33239 CG33239-PA ) or ( cAMP-dependent protein kinase R1 CG3263-PI, isoform I ) or ( cAMP-dependent protein kinase R1 CG3263-PH, isoform H ) or ( cAMP-dependent protein kinase R1 CG3263-PG, isoform G ) or ( cAMP-dependent protein kinase R1 CG3263-PA, isoform A ) or ( cAMP-dependent protein kinase R1 CG3263-PB, isoform B ) or ( cAMP-dependent protein kinase R1 CG3263-PD, isoform D ) or ( cAMP-dependent protein kinase R1 CG3263-PE, isoform E ) or ( cAMP-dependent protein kinase R1 CG3263-PJ, isoform J ) or ( Casein kinase II beta subunit CG15224-PD, isoform D ) or ( Ste:CG33236 CG33236-PA ) or ( Epac CG34392-PD, isoform D ) or ( Ste:CG33240 CG33240-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANYLCYC__45__RXN" name="Guanylate cyclase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gyc88E ) or ( Gyc88E ) or ( Gycalpha99B ) or ( Gyc76C ) or ( Gyc76C ) or ( Gyc-89Db ) or ( CG14877 ) or ( Gyc76C ) or ( CG10738 ) or ( CG10738 ) or ( Gyc88E ) or ( Gyc-89Da ) or ( CG31183 ) or ( Gyc32E ) or ( CG3216 ) or ( CG33958 ) or ( Gycbeta100B ) or ( CG3618 ) or ( Gyc-89Da ) or ( CG34357 ) or ( CG3216 ) or ( CG34357 ) or ( Gyc32E )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Guanylyl cyclase at 88E CG4154-PD, isoform D ) or ( Guanylyl cyclase at 88E CG4154-PC, isoform C ) or ( Guanyl cyclase alpha-subunit at 63A ) or ( Guanylyl cyclase at 76C CG8742-PA, isoform A ) or ( Guanylyl cyclase at 76C CG8742-PB, isoform B ) or ( Guanylyl cyclase at 89Db CG14886-PA ) or ( CG14877 CG14877-PA ) or ( Guanylyl cyclase at 76C CG8742-PC, isoform C ) or ( CG10738 CG10738-PB, isoform B ) or ( CG10738 CG10738-PA, isoform A ) or ( Guanylyl cyclase at 88E CG4154-PA, isoform A ) or ( Guanylyl cyclase at 89Da CG14885-PC, isoform C ) or ( CG31183 CG31183-PA ) or ( Guanyl cyclase at 32E CG33114-PA, isoform A ) or ( CG3216 CG3216-PB, isoform B ) or ( CG33958 CG33958-PA ) or ( Guanylyl cyclase beta-subunit at 100B CG1470-PA ) or ( CG3618 CG3618-PA ) or ( Guanylyl cyclase at 89Da CG14885-PB, isoform B ) or ( CG14652 ) or ( CG3216 CG3216-PA, isoform A ) or ( CG14652 ) or ( Guanyl cyclase at 32E CG33114-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.6.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CGMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5114" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aay )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( astray CG3705-PA )</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__P__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARALKYLAMINE__45__N__45__ACETYLTRANSFERASE__45__RXN" name="Aralkylamine N-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dat ) or ( Dat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dopamine N acetyltransferase CG3318-PB, isoform B ) or ( Dopamine N acetyltransferase CG3318-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.87</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__Arylethylamines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__N__45__Acetyl__45__2__45__Arylethylamines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8461" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: betalain biosynthesis (to betalamic acid)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8650" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8651" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTIDINE__45__DECARBOXYLASE__45__RXN" name="Histidine decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hdc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Histidine decarboxylase CG3454-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.22</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HISTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8730" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( synj ) or ( CG3573 ) or ( synj ) or ( 5PtaseI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( synaptojanin CG6562-PA, isoform A ) or ( CG3573 CG3573-PA ) or ( synaptojanin CG6562-PB, isoform B ) or ( 5PtaseI CG31107-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.56</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__506" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL__45__1__45__3__45__4__45__TRIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R223__45__RXN" name="long-chain-fatty-acid-CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6178 ) or ( CG3961 ) or ( CG9009 ) or ( CG3961 ) or ( l(2)44DEa ) or ( l(2)44DEa ) or ( CG3961 ) or ( CG18155 ) or ( CG4500 ) or ( l(2)44DEa ) or ( l(2)44DEa ) or ( CG18155 ) or ( l(2)44DEa ) or ( l(2)44DEa ) or ( l(2)44DEa ) or ( l(2)44DEa ) or ( l(2)44DEa ) or ( bgm ) or ( CG12512 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6178 CG6178-PA ) or ( CG3961 CG3961-PA, isoform A ) or ( CG9009 CG9009-PA ) or ( CG3961 CG3961-PC, isoform C ) or ( lethal (2) 44DEa CG8732-PD, isoform D ) or ( lethal (2) 44DEa CG8732-PI, isoform I ) or ( CG3961 CG3961-PB, isoform B ) or ( CG18155 CG18155-PA, isoform A ) or ( CG4500 CG4500-PA ) or ( lethal (2) 44DEa CG8732-PB, isoform B ) or ( lethal (2) 44DEa CG8732-PE, isoform E ) or ( CG18155 CG18155-PB, isoform B ) or ( lethal (2) 44DEa CG8732-PA, isoform A ) or ( lethal (2) 44DEa CG8732-PC, isoform C ) or ( lethal (2) 44DEa CG8732-PH, isoform H ) or ( lethal (2) 44DEa CG8732-PG, isoform G ) or ( lethal (2) 44DEa CG8732-PF, isoform F ) or ( bubblegum CG4501-PA ) or ( CG12512 CG12512-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__195" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OCTANOYL__45__COA" stoichiometry="1"/>
      <speciesReference species="CPD__45__196" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GPPSYN__45__RXN" name="Dimethylallyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( qm ) or ( Fpps )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quemao CG8593-PA ) or ( Farnesyl pyrophosphate synthase CG12389-PA )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__FORMYL__45__THF__45__CYCLO__45__LIGASE__45__RXN" name="5-formyltetrahydrofolate cyclo-ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9875 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9875 CG9875-PA )</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPTOPHAN__45__5__45__MONOOXYGENASE__45__RXN" name="Tryptophan 5-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hn ) or ( Hn ) or ( Trh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Henna CG7399-PA, isoform A ) or ( Henna CG7399-PB, isoform B ) or ( Tryptophan hydroxylase CG9122-PA )</html:p>
<html:p>SUBSYSTEM: serotonin and melatonin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.16.4</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CPD__45__5881</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
      <speciesReference species="_5__45__HYDROXY__45__TRYPTOPHAN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNKIN__45__RXN" name="D-mannose transport" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hex-A ) or ( Hex-A ) or ( Hex-C )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Hexokinase A CG3001-PB, isoform B ) or ( Hexokinase A CG3001-PA, isoform A ) or ( Hexokinase C CG8094-PA )</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>SUBSYSTEM: mannitol degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.7</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PREPHENATEDEHYDRAT__45__RXN" name="Prephenate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( trpgamma ) or ( trpgamma )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trpgamma CG5996-PB, isoform B ) or ( trpgamma CG5996-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.51</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PREPHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8772" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6084 ) or ( CG12766 ) or ( CG6083 ) or ( CG9436 ) or ( CG10863 ) or ( CG6084 ) or ( CG10638 ) or ( CG10638 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6084-PB, isoform B ) or ( CG12766 CG12766-PA ) or ( CG6083 CG6083-PA ) or ( CG9436 CG9436-PA ) or ( CG10863 CG10863-PA ) or ( CG6084-PA, isoform A ) or ( CG10638 CG10638-PB, isoform B ) or ( CG10638 CG10638-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ARABINOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ARABITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGSUCCINSYN__45__RXN" name="argininosuccinate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1315 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1315 CG1315-PA )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: citrulline-nitric oxide cycle</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ARGININO__45__SUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRIC__45__OXIDE__45__SYNTHASE__45__RXN" name="Nitric-oxide synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nos ) or ( Nos ) or ( Nos ) or ( Nos ) or ( Nos ) or ( Nos ) or ( Nos ) or ( Nos ) or ( Nos ) or ( Nos )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nitric oxide synthase CG6713-PG, isoform G ) or ( Nitric oxide synthase CG6713-PE, isoform E ) or ( Nitric oxide synthase CG6713-PA, isoform A ) or ( Nitric oxide synthase CG6713-PC, isoform C ) or ( Nitric oxide synthase CG6713-PD, isoform D ) or ( Nitric oxide synthase CG6713-PB, isoform B ) or ( Nitric oxide synthase CG6713-PJ, isoform J ) or ( Nitric oxide synthase CG6713-PI, isoform I ) or ( Nitric oxide synthase CG6713-PF, isoform F ) or ( Nitric oxide synthase CG6713-PH, isoform H )</html:p>
<html:p>SUBSYSTEM: citrulline-nitric oxide cycle</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.39</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NITRIC__45__OXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRIC__45__OXIDE" stoichiometry="1"/>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GALACTOSE_TO_UDP_COF_RXN" name="UDP-GALACTOSE_TO_UDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8086" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt36Bc ) or ( Ext2 ) or ( Ext2 ) or ( Ugt86Di ) or ( Ugt86Dd ) or ( CG5724 ) or ( CG5999 ) or ( Ugt37b1 ) or ( GlcAT-P ) or ( ttv ) or ( GlcAT-S ) or ( GlcAT-P ) or ( CG15661 ) or ( Ugt86Dh ) or ( Ugt37c1 ) or ( GlcAT-P ) or ( Ugt86Dc ) or ( Act57B ) or ( GlcAT-S ) or ( CG3797 ) or ( GlcAT-I ) or ( CG17323 ) or ( Ugt58Fa ) or ( Ugt86De ) or ( Ugt86Dg ) or ( Act57B ) or ( Ugt36Bc ) or ( Ugt36Ba ) or ( CG11289 ) or ( CG6475 ) or ( Ugt36Bb ) or ( Ugt35b ) or ( CG4302 ) or ( CG31002 ) or ( Ugt35a ) or ( CG15661 ) or ( CG10178 ) or ( Ugt86Dj ) or ( Ugt86Da ) or ( CG9220 ) or ( Ugt37a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ugt36Bc CG17932-PB, isoform B ) or ( CG8433-PA, isoform A ) or ( CG8433-PB, isoform B ) or ( Ugt86Di CG6658-PA ) or ( Ugt86Dd CG6633-PB ) or ( CG5724 CG5724-PA ) or ( CG5999 CG5999-PA ) or ( UDP-glycosyltransferase 37b1 CG9481-PA ) or ( GlcAT-P CG6207-PC, isoform C ) or ( tout-velu CG10117-PA ) or ( GlcAT-S CG3881-PB, isoform B ) or ( GlcAT-P CG6207-PB, isoform B ) or ( CG15661 CG15661-PA, isoform A ) or ( Ugt86Dh CG4772-PA ) or ( UDP-glycosyltransferase 37c1 CG8652-PA ) or ( GlcAT-P CG6207-PA, isoform A ) or ( Ugt86Dc CG4739-PA ) or ( Actin 57B CG10067-PB, isoform B ) or ( GlcAT-S CG3881-PA, isoform A ) or ( CG3797 CG3797-PA ) or ( GlcAT-I CG32775-PA ) or ( CG17323 CG17323-PA ) or ( Ugt58Fa CG4414-PA ) or ( Ugt86De CG6653-PA ) or ( Ugt86Dg CG17200-PA ) or ( Actin 57B CG10067-PA, isoform A ) or ( Ugt36Bc CG17932-PA, isoform A ) or ( Ugt36Ba CG13270-PA ) or ( CG11289 CG11289-PA ) or ( CG6475 CG6475-PB ) or ( Ugt36Bb CG13271-PA ) or ( UDP-glycosyltransferase ) or ( CG4302 CG4302-PA ) or ( CG31002 CG31002-PA ) or ( UDP-glycosyltransferase 35a CG6644-PA ) or ( CG15661 CG15661-PB, isoform B ) or ( CG10178 CG10178-PA ) or ( Ugt86Dj CG15902-PA ) or ( Ugt86Da CG18578-PA ) or ( CG9220 CG9220-PC ) or ( UDP-glycosyltransferase 37a1 CG11012-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7610" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7612" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIPHOSPHOMEVALONTE__45__DECARBOXYLASE__45__RXN" name="Diphosphomevalonate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG8239 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG8239 CG8239-PA )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.33</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__641" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_P__45__COUMAROYL__45__COA_COF_RXN" name="CO-A_TO_P-COUMAROYL-COA_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__COUMAROYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__300" name="Glyoxylate reductase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG31674 ) or ( CG31673 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG31674 CG31674-PA ) or ( CG31673 CG31673-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.79</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLINE__45__KINASE__45__RXN" name="Choline kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG2201 ) or ( CG2201 ) or ( CG2201 ) or ( CG2201 ) or ( CG2201 ) or ( eas ) or ( eas ) or ( eas ) or ( eas ) or ( eas )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2201 CG2201-PA, isoform A ) or ( CG2201 CG2201-PB, isoform B ) or ( CG2201 CG2201-PE, isoform E ) or ( CG2201 CG2201-PC, isoform C ) or ( CG2201 CG2201-PD, isoform D ) or ( easily shocked CG3525-PA, isoform A ) or ( easily shocked CG3525-PD, isoform D ) or ( easily shocked CG3525-PE, isoform E ) or ( easily shocked CG3525-PC, isoform C ) or ( easily shocked CG3525-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.32</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Deoxy__45__Ribonucleosides__124___TO___124__Deoxy__45__Ribonucleoside__45__Monophosphates__124___COF_RXN" name="|Deoxy-Ribonucleosides|_TO_|Deoxy-Ribonucleoside-Monophosphates|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxy__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Deoxy__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="INOPHOSPHOR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG16758 ) or ( CG16758 ) or ( CG16758 ) or ( CG16758 ) or ( CG18128 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG16758 CG16758-PD, isoform D ) or ( CG16758 CG16758-PE, isoform E ) or ( CG16758 CG16758-PB, isoform B ) or ( CG16758 CG16758-PF, isoform F ) or ( CG18128 CG18128-PA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5901" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( scu )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( scully CG7113-PA )</html:p>
<html:p>SUBSYSTEM: polyhydroxybutyrate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.36</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: CPD__45__650</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOSIDE__45__DIP__45__KIN__45__RXN" name="Nucleoside-diphosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG15547 ) or ( nmdyn-D7 ) or ( awd ) or ( nmdyn-D6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG15547 CG15547-PA ) or ( nmdyn-D7 CG8362-PA ) or ( Killer of prune ) or ( nmdyn-D6 CG5310-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__45__PHOSPHATIDYLINOSITOL__45__3__45__KINASE__45__RXN" name="1-phosphatidylinositol 3-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pi3K92E ) or ( Pi3K68D ) or ( Pi3K68D ) or ( Nrx-IV ) or ( Pi3K92E ) or ( Nrx-IV ) or ( Pi3K68D ) or ( Pi3K59F )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PI 3-kinase ) or ( Phosphotidylinositol 3 kinase 68D CG11621-PB, isoform B ) or ( Phosphotidylinositol 3 kinase 68D CG11621-PA, isoform A ) or ( Neurexin IV CG6827-PB, isoform B ) or ( PI 3-kinase ) or ( Neurexin IV CG6827-PA, isoform A ) or ( Phosphotidylinositol 3 kinase 68D CG11621-PC, isoform C ) or ( Phosphotidylinositol 3 kinase 59F CG5373-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.137</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__L__45__1__45__phosphatidyl__45__inositols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__177" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7226" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( qm ) or ( Fpps )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quemao CG8593-PA ) or ( Farnesyl pyrophosphate synthase CG12389-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6641" stoichiometry="1"/>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6645" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_ACETYL__45__COA_COF_RXN" name="CO-A_TO_ACETYL-COA_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__4__46__1__46__14__45__RXN" name="1-aminocyclopropane-1-carboxylate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1640 ) or ( CG1640 ) or ( CG6950 ) or ( CG1640 ) or ( CG1640 ) or ( CG1640 ) or ( CG6950 ) or ( CG1640 ) or ( CG1461 ) or ( CG6950 ) or ( CG6950 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1640 CG1640-PE, isoform E ) or ( CG1640 CG1640-PA, isoform A ) or ( CG6950 CG6950-PD, isoform D ) or ( CG1640 CG1640-PC, isoform C ) or ( CG1640 CG1640-PB, isoform B ) or ( CG1640 CG1640-PD, isoform D ) or ( CG6950 CG6950-PB, isoform B ) or ( CG1640 CG1640-PF, isoform F ) or ( CG1461 CG1461-PA ) or ( CG6950 CG6950-PC, isoform C ) or ( CG6950 CG6950-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: ethylene biosynthesis from methionine</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.14</html:p>
<html:p>SIDE: _5__45__METHYLTHIOADENOSINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__68" stoichiometry="1"/>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSE__45__6__45__PHOSPHATASE__45__RXN" name="Glucose-6-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG15400 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG15400 CG15400-PB )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRIOSEPISOMERIZATION__45__RXN" name="Triosephosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Tpi ) or ( Tpi ) or ( Tpi )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2171-PC, isoform C ) or ( CG2171-PA, isoform A ) or ( CG2171-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__AMINOLEVULINIC__45__ACID__45__SYNTHASE__45__RXN" name="5-aminolevulinic acid synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Alas )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aminolevulinate synthase CG3017-PA )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.37</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5146" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9485 ) or ( CG9485 ) or ( CG9485 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9485 CG9485-PA, isoform A ) or ( CG9485 CG9485-PB, isoform B ) or ( CG9485 CG9485-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.33</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__971" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1027" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KYNURENINE__45__3__45__MONOOXYGENASE__45__RXN" name="Kynurenine 3-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cn )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cinnabar CG1555-PA )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.9</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__L__45__KYNURENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5226" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hexo1 ) or ( fdl ) or ( Hexo1 ) or ( Hexo1 ) or ( CG15012 ) or ( fdl ) or ( Hexo2 ) or ( Hexo1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Hexosaminidase 1 CG1318-PA, isoform A ) or ( fused lobes CG8824-PC, isoform C ) or ( Hexosaminidase 1 CG1318-PD, isoform D ) or ( Hexosaminidase 1 CG1318-PB, isoform B ) or ( CG15012 CG15012-PB ) or ( fused lobes CG8824-PB, isoform B ) or ( Hexosaminidase 2 CG1787-PA ) or ( Hexosaminidase 1 CG1318-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.52</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1081" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
      <speciesReference species="CPD0__45__882" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5225" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PGRP-LA ) or ( PGRP-SB2 ) or ( PGRP-SD ) or ( PGRP-SB1 ) or ( PGRP-LC ) or ( PGRP-LB ) or ( PGRP-LB ) or ( PGRP-LA ) or ( PGRP-SC1b ) or ( PGRP-LE ) or ( PGRP-LA ) or ( PGRP-LF ) or ( PGRP-LA ) or ( PGRP-SC1a ) or ( PGRP-LC ) or ( PGRP-LC ) or ( PGRP-SC2 ) or ( PGRP-SA ) or ( PGRP-LB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Peptidoglycan recognition protein LA CG32042-PC, isoform C ) or ( PGRP-SB2 CG9697-PA ) or ( PGRP-SD CG7496-PA ) or ( PGRP-SB1 CG9681-PA ) or ( Peptidoglycan recognition protein LC CG4432-PA, isoform A ) or ( Peptidoglycan recognition protein LB CG14704-PB, isoform B ) or ( Peptidoglycan recognition protein LB CG14704-PA, isoform A ) or ( Peptidoglycan recognition protein LA CG32042-PE, isoform E ) or ( PGRP-SC1b CG8577-PA ) or ( Peptidoglycan recognition protein LE CG8995-PA ) or ( Peptidoglycan recognition protein LA CG32042-PF, isoform F ) or ( Peptidoglycan recognition protein LF CG4437-PA ) or ( Peptidoglycan recognition protein LA CG32042-PD, isoform D ) or ( PGRP-SC1a CG14746-PA ) or ( Peptidoglycan recognition protein LC CG4432-PC, isoform C ) or ( Peptidoglycan recognition protein LC CG4432-PB, isoform B ) or ( PGRP-SC2 CG14745-PA ) or ( Peptidoglycan recognition protein SA CG11709-PA ) or ( Peptidoglycan recognition protein LB CG14704-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.28</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1080" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1082" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1081" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOVALERYL__45__COA__45__FAD__45__RXN" name="Isovaleryl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6638 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6638 CG6638-PA )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.10</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVALERYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__221" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tdc1 ) or ( Ddc ) or ( amd ) or ( Tdc2 ) or ( amd ) or ( Ddc ) or ( Ddc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Tyrosine decarboxylase 1 CG30445-PA ) or ( Dopa decarboxylase CG10697-PB, isoform B ) or ( alpha methyl dopa-resistant CG10501-PA, isoform A ) or ( Tyrosine decarboxylase 2 CG30446-PA ) or ( alpha methyl dopa-resistant CG10501-PB, isoform B ) or ( Dopa decarboxylase CG10697-PC, isoform C ) or ( Dopa decarboxylase CG10697-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis (via dopamine)</html:p>
<html:p>SUBSYSTEM: catecholamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.28</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROURACIL__45__DEHYDROGENASE__45__NAD__43____45__RXN" name="Dihydrouracil dehydrogenase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( su(r) ) or ( su(r) )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2194-PB, isoform B ) or ( CG2194-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__URACIL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URACIL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTONE__45__LYSINE__45__N__45__METHYLTRANSFERASE__45__RXN" name="Histone-lysine N-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1716 ) or ( CG4565 ) or ( egg ) or ( CG2995 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1716 CG1716-PA ) or ( CG4565 CG4565-PB ) or ( CG12196-PA ) or ( CG2995 CG2995-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.43</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8578" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8579" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TIGLYLCOA__45__HYDROXY__45__RXN" name="Enoyl-CoA hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6984 ) or ( CG6543 ) or ( CG8778 ) or ( CG6543 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6984 CG6984-PA ) or ( CG6543 CG6543-PA, isoform A ) or ( CG8778 CG8778-PA ) or ( CG6543 CG6543-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation I</html:p>
<html:p>SUBSYSTEM: 2-methylbutyrate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TIGLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__METHYL__45__3__45__HYDROXY__45__BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FADSYN__45__RXN" name="FMN adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG16848 ) or ( CG4407 ) or ( CG4407 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG16848 CG16848-PA ) or ( CG4407 CG4407-PB, isoform B ) or ( CG4407 CG4407-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENPHOSPHOR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG16758 ) or ( CG16758 ) or ( CG16758 ) or ( CG16758 ) or ( CG18128 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG16758 CG16758-PD, isoform D ) or ( CG16758 CG16758-PE, isoform E ) or ( CG16758 CG16758-PB, isoform B ) or ( CG16758 CG16758-PF, isoform F ) or ( CG18128 CG18128-PA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__80__45__RXN" name="N-acetylgalactosamine-6-phosphate deacetylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG17065 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG17065 CG17065-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.25</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GALACTOSAMINE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="D__45__GALACTOSAMINE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRPPAMIDOTRANS__45__RXN" name="Amidophosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Prat2 ) or ( Prat ) or ( Prat2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoribosylamidotransferase 2 CG10078-PB, isoform B ) or ( Phosphoribosylamidotransferase CG2867-PA ) or ( Phosphoribosylamidotransferase 2 CG10078-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.14</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__P__45__BETA__45__D__45__RIBOSYL__45__AMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYBUTYRATE__45__DEHYDROGENASE__45__RXN" name="3-hydroxybutyrate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG12068 ) or ( CG13377 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG12068 CG12068-PA ) or ( CG13377 CG13377-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.30</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__335" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__3__46__12__45__RXN" name="6-pyruvoyltetrahydropterin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pr ) or ( pr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purple CG16784-PB, isoform B ) or ( purple CG16784-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.12</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRONEOPTERIN__45__P3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P3I" stoichiometry="1"/>
      <speciesReference species="_6__45__PYRUVOYL__45__5678__45__TETRAHYDROPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROCOLLAGEN__45__LYSINE__45__5__45__DIOXYGENASE__45__RXN" name="Procollagen-lysine 5-dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6199 ) or ( CG31915 ) or ( CG6199 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6199 CG6199-PB, isoform B ) or ( CG31915 CG31915-PA ) or ( CG6199 CG6199-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.4</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROCOLLAGEN__45__L__45__LYSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROCOLLAGEN__45__5__45__HYDROXY__45__L__45__LYSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIPHTHINE__45__SYNTHASE__45__RXN" name="Diphthine synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dph5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Diphthamide methyltransferase CG31289-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.98</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__3__45__CARBOXY__45__3__45__AMINOPROPYL__45__L__45__HISTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__3__45__CARBOXY__45__3__45__METHYLAMMONIOPROPYL__45__L__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8853" name="Sepiapterin reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Es2 ) or ( Sptr ) or ( CG12116 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Es2 CG1474-PA ) or ( Sepiapterin reductase CG12117-PA ) or ( CG12116 CG12116-PA )</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.153</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6__45__PYRUVOYL__45__5678__45__TETRAHYDROPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPDEPHOS__45__RXN" name="Pyruvate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7069 ) or ( PyK ) or ( CG12229 ) or ( PyK ) or ( CG7362 ) or ( CG11249 ) or ( CG2964 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7069 CG7069-PA ) or ( Pyruvate kinase CG7070-PB, isoform B ) or ( CG12229 CG12229-PA ) or ( Pyruvate kinase CG7070-PA, isoform A ) or ( CG7362 CG7362-PA ) or ( CG11249 CG11249-PA ) or ( CG2964 CG2964-PA )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.40</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOLIPASE__45__C__45__RXN" name="Phospholipase C" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( norpA ) or ( norpA ) or ( norpA ) or ( norpA ) or ( CG10747 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( no receptor potential A CG3620-PA, isoform A ) or ( no receptor potential A CG3620-PD, isoform D ) or ( no receptor potential A CG3620-PB, isoform B ) or ( no receptor potential A CG3620-PC, isoform C ) or ( CG10747 CG10747-PA )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5216" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( alpha-Man-I ) or ( alpha-Man-I ) or ( alpha-Man-I ) or ( alpha-Man-I ) or ( alpha-Man-I ) or ( alpha-Man-I ) or ( alpha-Man-I )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha Mannosidase I CG32684-PD, isoform D ) or ( alpha Mannosidase I CG32684-PC, isoform C ) or ( alpha Mannosidase I CG32684-PF, isoform F ) or ( alpha Mannosidase I CG32684-PE, isoform E ) or ( alpha Mannosidase I CG32684-PA, isoform A ) or ( alpha Mannosidase I CG32684-PB, isoform B ) or ( alpha Mannosidase I CG32684-PG, isoform G )</html:p>
<html:p>SUBSYSTEM: 2-O-&amp;alpha;-mannosyl-D-glycerate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1063" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYSINE__45__N__45__ACETYLTRANSFERASE__45__RXN" name="Lysine N-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mof )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( males absent on the first CG3025-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.32</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__P" stoichiometry="1"/>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__567" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5341" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG33090 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG33090 CG33090-PB )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.21</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LINAMARIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__HYDROXY__45__2__45__METHYLPROPANENITRILE" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XYLISOM__45__RXN" name="Xylose isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( beta4GalNAcTA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta4GalNAcTA CG8536-PA )</html:p>
<html:p>SUBSYSTEM: xylose degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6384" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5044 ) or ( CG5044 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5044 CG5044-PA, isoform A ) or ( CG5044 CG5044-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="_3__45__HYDROXY__45__PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AICARSYN__45__RXN" name="Adenylosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG3590 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG3590 CG3590-PA )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.2</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AICAR" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRROLINECARBDEHYDROG__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG33092 ) or ( CG33092 ) or ( CG33092 ) or ( CG7145 ) or ( CG7145 ) or ( CG7145 ) or ( CG33092 ) or ( CG6661 ) or ( CG33092 ) or ( CG33092 ) or ( CG33092 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG33092 CG33092-PD, isoform D ) or ( CG33092 CG33092-PE, isoform E ) or ( CG33092 CG33092-PG, isoform G ) or ( CG7145 CG7145-PD, isoform D ) or ( CG7145 CG7145-PA, isoform A ) or ( CG7145 CG7145-PB, isoform B ) or ( CG33092 CG33092-PA, isoform A ) or ( CG6661 CG6661-PA ) or ( CG33092 CG33092-PB, isoform B ) or ( CG33092 CG33092-PC, isoform C ) or ( CG33092 CG33092-PF, isoform F )</html:p>
<html:p>SUBSYSTEM: proline degradation I</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFITE__45__OXIDASE__45__RXN" name="Sulfite oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7280 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7280 CG7280-PA )</html:p>
<html:p>SUBSYSTEM: sulfite oxidation IV</html:p>
<html:p>PROTEIN_CLASS: 1.8.3.1</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6382" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9629 ) or ( CG31075 ) or ( Aldh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9629 CG9629-PA ) or ( CG31075 CG31075-PA ) or ( Aldehyde dehydrogenase CG3752-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6082" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8486" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis (via dopamine)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CPD__45__8651</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
      <speciesReference species="CPD__45__8651" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8659" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6383" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6984 ) or ( CG6543 ) or ( CG8778 ) or ( CG6543 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6984 CG6984-PA ) or ( CG6543 CG6543-PA, isoform A ) or ( CG8778 CG8778-PA ) or ( CG6543 CG6543-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACRYLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOPORGENOXI__45__RXN" name="Protoporphyrinogen oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ppox ) or ( CG9531 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Protoporphyrinogen oxidase CG5796-PA ) or ( CG9531 CG9531-PA )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOPORPHYRINOGEN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPORPHYRIN_IX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__KETOGLUTARATE_TO_GLT_COF_RXN" name="2-KETOGLUTARATE_TO_GLT_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__43__45__RXN" name="[Pyruvate dehydrogenase (lipoamide)]-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pdp ) or ( CG3626 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pyruvate dehydrogenase phosphatase CG12151-PA ) or ( CG3626 CG3626-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.43</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__91__PYRUVATE__32__DEHYDROGENASE__32____40__LIPOAMIDE__41____93____32__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__91__PYRUVATE__32__DEHYDROGENASE__32____40__LIPOAMIDE__41____93__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLU6PDEHYDROG__45__RXN" name="Glucose-6-phosphate 1-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Zw ) or ( CG7140 ) or ( Zw )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Zwischenferment CG12529-PA, isoform A ) or ( CG7140 CG7140-PA ) or ( Zwischenferment CG12529-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.49</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERDEAM__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG12264 ) or ( Eip55E )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG12264 CG12264-PA ) or ( Eip55E CG5345-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8642" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Idh ) or ( Idh ) or ( Idh ) or ( Idh ) or ( Idh ) or ( Idh ) or ( Idh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Isocitrate dehydrogenase CG7176-PG, isoform G ) or ( Isocitrate dehydrogenase CG7176-PC, isoform C ) or ( Isocitrate dehydrogenase CG7176-PB, isoform B ) or ( Isocitrate dehydrogenase CG7176-PD, isoform D ) or ( Isocitrate dehydrogenase CG7176-PE, isoform E ) or ( Isocitrate dehydrogenase CG7176-PA, isoform A ) or ( Isocitrate dehydrogenase CG7176-PF, isoform F )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.42</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALO__45__SUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMP__45__DEPHOSPHORYLATION__45__RXN" name="5&apos;-nucleotidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG2862 ) or ( CG11883 ) or ( CG1961 ) or ( CG11883 ) or ( CG2862 ) or ( CG4827 ) or ( CG11883 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG32549 ) or ( CG11126 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2862 CG2862-PA, isoform A ) or ( CG11883 CG11883-PA, isoform A ) or ( CG1961 CG1961-PA ) or ( CG11883 CG11883-PC, isoform C ) or ( CG2862 CG2862-PB, isoform B ) or ( CG4827 CG4827-PA ) or ( CG11883 CG11883-PB, isoform B ) or ( CG32549 CG32549-PE, isoform E ) or ( CG32549 CG32549-PA, isoform A ) or ( CG32549 CG32549-PB, isoform B ) or ( CG32549 CG32549-PC, isoform C ) or ( CG32549 CG32549-PF, isoform F ) or ( CG32549 CG32549-PD, isoform D ) or ( CG11126 CG11126-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UMPKI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dak1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dak1 CG6092-PA )</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides interconversion</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2PTERIDINEPYROPHOSPHOKIN__45__RXN" name="2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nompC ) or ( nompC ) or ( nompC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( no mechanoreceptor potential C CG11020-PA, isoform A ) or ( no mechanoreceptor potential C CG11020-PC, isoform C ) or ( no mechanoreceptor potential C CG11020-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.3</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__OH__45__HYDROXYMETHYL__45__DIHYDROPTERIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROPTERIN__45__CH2OH__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__81" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fmo-2 ) or ( Fmo-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Flavin-containing monooxygenase 2 CG3174-PA ) or ( Flavin-containing monooxygenase 1 CG3006-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.8</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2743" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FGAMSYN__45__RXN" name="phosphoribosylformylglycinamidine synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ade2 ) or ( ade2 ) or ( ade2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenosine 2 CG9127-PC, isoform C ) or ( adenosine 2 CG9127-PB, isoform B ) or ( adenosine 2 CG9127-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DOPAMINE__45__BETA__45__MONOOXYGENASE__45__RXN" name="Dopamine-&amp;beta;-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nahoda ) or ( Tbh ) or ( knk ) or ( olf413 ) or ( CG14681 ) or ( CG14681 ) or ( CG5235 ) or ( nahoda )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nahoda CG12781-PA, isoform A ) or ( Tyramine beta hydroxylase CG1543-PB ) or ( gnarled ) or ( olf413 CG12673-PA ) or ( CG14681-PA, isoform A ) or ( CG14681-PB, isoform B ) or ( CG5235 CG5235-PA ) or ( nahoda CG12781-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: catecholamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.17.1</html:p>
<html:p>SIDE: L__45__DEHYDRO__45__ASCORBATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: ASCORBATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NOREPINEPHRINE" stoichiometry="1"/>
      <speciesReference species="L__45__DEHYDRO__45__ASCORBATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOGENTISATE__45__12__45__DIOXYGENASE__45__RXN" name="Homogentisate 1,2-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hgo )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homogentisate 1,2-dioxygenase CG4779-PA )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.5</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMOGENTISATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__MALEYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2141" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG11909 ) or ( LvpD ) or ( CG6453 ) or ( CG7685 ) or ( CG14935 ) or ( CG14934 ) or ( CG14476 ) or ( CG11669 ) or ( CG14476 ) or ( CG8690 ) or ( CG8693 ) or ( CG33080 ) or ( CG33080 ) or ( CG14935 ) or ( LvpH ) or ( LvpL ) or ( CG14476 ) or ( CG14476 ) or ( CG14476 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG11909 CG11909-PA ) or ( Larval visceral protein D CG8694-PA ) or ( CG6453 CG6453-PA ) or ( CG7685 CG7685-PA ) or ( CG14935 CG14935-PA, isoform A ) or ( CG14934 CG14934-PA ) or ( CG14476 CG14476-PB, isoform B ) or ( CG11669 CG11669-PA ) or ( CG14476 CG14476-PC, isoform C ) or ( CG8690 CG8690-PA ) or ( CG8693 CG8693-PA ) or ( CG33080 CG33080-PB, isoform B ) or ( CG33080 CG33080-PA, isoform A ) or ( CG14935 CG14935-PB, isoform B ) or ( Larval visceral protein H CG8696-PA ) or ( Larval visceral protein L CG8695-PA ) or ( CG14476 CG14476-PA, isoform A ) or ( CG14476 CG14476-PD, isoform D ) or ( CG14476 CG14476-PE, isoform E )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.20</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__MALTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLYLSULFKIN__45__RXN" name="Adenylylsulfate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Paps ) or ( Paps ) or ( Paps ) or ( Paps ) or ( Paps ) or ( Paps )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PAPS synthetase CG8363-PD, isoform D ) or ( PAPS synthetase CG8363-PE, isoform E ) or ( PAPS synthetase CG8363-PA, isoform A ) or ( PAPS synthetase CG8363-PF, isoform F ) or ( PAPS synthetase CG8363-PB, isoform B ) or ( PAPS synthetase CG8363-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: sulfate activation for sulfonation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.25</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="APS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PAPS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_PROPIONYL__45__COA_COF_RXN" name="CO-A_TO_PROPIONYL-COA_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCC__45__FUM__45__OXRED__45__RXN" name="Succinate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6629 ) or ( CG6666 ) or ( CG10219 ) or ( CG7349 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6629 CG6629-PA ) or ( CG6666 CG6666-PA ) or ( CG10219 CG10219-PA ) or ( CG7349 CG7349-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPTIDYLGLYCINE__45__MONOOXYGENASE__45__RXN" name="Peptidylglycine monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pal ) or ( Pal ) or ( Phm ) or ( Pal ) or ( CG12130 ) or ( Phm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase CG5472-PC, isoform C ) or ( Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase CG5472-PB, isoform B ) or ( Peptidylglycine-alpha-hydroxylating monooxygenase CG3832-PB, isoform B ) or ( Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase CG5472-PA, isoform A ) or ( CG12130 CG12130-PA ) or ( Peptidylglycine-alpha-hydroxylating monooxygenase CG3832-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.17.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Glycines__124__" stoichiometry="1"/>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8528" stoichiometry="1"/>
      <speciesReference species="L__45__DEHYDRO__45__ASCORBATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__66__45__RXN" name="Inositol-3,4-bisphosphate 4-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG33249 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG33249 CG33249-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.66</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__PHOSPHATIDYL__45__MYO__45__INOSITOL__45__34__45__BISPHOSP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__177" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALPHAGALACTOSID__45__RXN" name="&amp;alpha;-galactosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7997 ) or ( CG7997 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7997 CG7997-PA, isoform A ) or ( CG7997 CG7997-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: melibiose degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.22</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MELIBIOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8635" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Prx2540-2 ) or ( kek5 ) or ( kek2 ) or ( Prx6005 ) or ( CG12896 ) or ( Pxn ) or ( Pxd ) or ( Irc ) or ( Pxn ) or ( Pxn ) or ( Prx5037 ) or ( CG6879 ) or ( pxt ) or ( CG4009 ) or ( Cat ) or ( CG6969 ) or ( Prx2540-1 ) or ( CG13889 ) or ( CG9314 ) or ( da ) or ( Jafrac2 ) or ( kek6 ) or ( CG10211 ) or ( disp ) or ( Jafrac1 ) or ( PHGPx ) or ( Duox ) or ( Jafrac1 ) or ( Jafrac2 ) or ( CG33123 ) or ( CG10793 ) or ( pxt ) or ( PHGPx ) or ( CG5873 ) or ( PHGPx ) or ( PHGPx ) or ( Pxn ) or ( kek5 ) or ( Pxn )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Peroxiredoxin 2540 CG11765-PA ) or ( kekkon5 CG12199-PA, isoform A ) or ( kekkon-2 CG4977-PA ) or ( Peroxiredoxin 6005 CG3083-PA ) or ( CG12896 CG12896-PA ) or ( Peroxidasin CG12002-PC, isoform C ) or ( Peroxidase CG3477-PA ) or ( Immune-regulated catalase CG8913-PA ) or ( Peroxidasin CG12002-PD, isoform D ) or ( Peroxidasin CG12002-PE, isoform E ) or ( Peroxiredoxin 5037 CG5826-PA ) or ( CG6879 CG6879-PA ) or ( pxt CG7660-PA, isoform A ) or ( CG4009 CG4009-PA ) or ( Catalase CG6871-PA ) or ( CG6969 CG6969-PA ) or ( Peroxiredoxin 2540 CG12405-PA ) or ( CG13889 CG13889-PA ) or ( CG9314 CG9314-PA ) or ( daughterless CG5102-PA ) or ( thioredoxin peroxidase 2 CG1274-PB, isoform B ) or ( kek6 CG1804-PA ) or ( CG10211 CG10211-PA ) or ( dispatched CG2019-PA ) or ( thioredoxin peroxidase 1 CG1633-PA, isoform A ) or ( PHGPx CG12013-PA, isoform A ) or ( Dual oxidase CG3131-PA ) or ( thioredoxin peroxidase 1 CG1633-PB, isoform B ) or ( thioredoxin peroxidase 2 CG1274-PA, isoform A ) or ( CG33123 CG33123-PA ) or ( CG10793 CG10793-PA ) or ( pxt CG7660-PB, isoform B ) or ( PHGPx CG12013-PB, isoform B ) or ( CG5873 CG5873-PA ) or ( PHGPx CG12013-PD, isoform D ) or ( PHGPx CG12013-PC, isoform C ) or ( Peroxidasin CG12002-PA, isoform A ) or ( kekkon5 CG12199-PB, isoform B ) or ( Peroxidasin CG12002-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: betanidin degradation</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.7</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8653" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8890" stoichiometry="1"/>
      <speciesReference species="CPD__45__8653" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2901" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7433 ) or ( CG7433 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7433 CG7433-PA, isoform A ) or ( CG7433 CG7433-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.19</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8631" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ald ) or ( Ald ) or ( Ald ) or ( Ald ) or ( Ald ) or ( CG5432 ) or ( Ald ) or ( Ald ) or ( Ald )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aldolase CG6058-PC, isoform C ) or ( Aldolase CG6058-PE, isoform E ) or ( Aldolase CG6058-PD, isoform D ) or ( Aldolase CG6058-PF, isoform F ) or ( Aldolase CG6058-PB, isoform B ) or ( CG5432 CG5432-PA ) or ( Aldolase CG6058-PG, isoform G ) or ( Aldolase CG6058-PA, isoform A ) or ( Aldolase CG6058-PH, isoform H )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="GLYCERALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CTP_TO_CDP_COF_RXN" name="CTP_TO_CDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GABATRANSAM__45__RXN" name="4-aminobutyrate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7433 ) or ( CG7433 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7433 CG7433-PA, isoform A ) or ( CG7433 CG7433-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation I</html:p>
<html:p>SUBSYSTEM: glutamate degradation IV</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.19</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_325__45__BISPHOSPHATE__45__NUCLEOTIDASE__45__RXN" name="3&apos;(2&apos;),5&apos;-bisphosphate nucleotidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7789 ) or ( CG15743 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7789 CG7789-PA ) or ( CG15743 CG15743-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PAP" stoichiometry="1"/>
      <speciesReference species="_3__45__5__45__ADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHASERDECARB__45__RXN" name="Phosphatidylserine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5991 ) or ( CG5991 ) or ( CG5991 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5991 CG5991-PA, isoform A ) or ( CG5991 CG5991-PC, isoform C ) or ( CG5991 CG5991-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: phosphatidyl-ethanolamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.65</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__83" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt36Bc ) or ( Ext2 ) or ( Ext2 ) or ( Ugt86Di ) or ( Ugt86Dd ) or ( CG5724 ) or ( CG5999 ) or ( Ugt37b1 ) or ( GlcAT-P ) or ( ttv ) or ( GlcAT-S ) or ( GlcAT-P ) or ( CG15661 ) or ( Ugt86Dh ) or ( Ugt37c1 ) or ( GlcAT-P ) or ( Ugt86Dc ) or ( Act57B ) or ( GlcAT-S ) or ( CG3797 ) or ( GlcAT-I ) or ( CG17323 ) or ( Ugt58Fa ) or ( Ugt86De ) or ( Ugt86Dg ) or ( Act57B ) or ( Ugt36Bc ) or ( Ugt36Ba ) or ( CG11289 ) or ( CG6475 ) or ( Ugt36Bb ) or ( Ugt35b ) or ( CG4302 ) or ( CG31002 ) or ( Ugt35a ) or ( CG15661 ) or ( CG10178 ) or ( Ugt86Dj ) or ( Ugt86Da ) or ( CG9220 ) or ( Ugt37a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ugt36Bc CG17932-PB, isoform B ) or ( CG8433-PA, isoform A ) or ( CG8433-PB, isoform B ) or ( Ugt86Di CG6658-PA ) or ( Ugt86Dd CG6633-PB ) or ( CG5724 CG5724-PA ) or ( CG5999 CG5999-PA ) or ( UDP-glycosyltransferase 37b1 CG9481-PA ) or ( GlcAT-P CG6207-PC, isoform C ) or ( tout-velu CG10117-PA ) or ( GlcAT-S CG3881-PB, isoform B ) or ( GlcAT-P CG6207-PB, isoform B ) or ( CG15661 CG15661-PA, isoform A ) or ( Ugt86Dh CG4772-PA ) or ( UDP-glycosyltransferase 37c1 CG8652-PA ) or ( GlcAT-P CG6207-PA, isoform A ) or ( Ugt86Dc CG4739-PA ) or ( Actin 57B CG10067-PB, isoform B ) or ( GlcAT-S CG3881-PA, isoform A ) or ( CG3797 CG3797-PA ) or ( GlcAT-I CG32775-PA ) or ( CG17323 CG17323-PA ) or ( Ugt58Fa CG4414-PA ) or ( Ugt86De CG6653-PA ) or ( Ugt86Dg CG17200-PA ) or ( Actin 57B CG10067-PA, isoform A ) or ( Ugt36Bc CG17932-PA, isoform A ) or ( Ugt36Ba CG13270-PA ) or ( CG11289 CG11289-PA ) or ( CG6475 CG6475-PB ) or ( Ugt36Bb CG13271-PA ) or ( UDP-glycosyltransferase ) or ( CG4302 CG4302-PA ) or ( CG31002 CG31002-PA ) or ( UDP-glycosyltransferase 35a CG6644-PA ) or ( CG15661 CG15661-PB, isoform B ) or ( CG10178 CG10178-PA ) or ( Ugt86Dj CG15902-PA ) or ( Ugt86Da CG18578-PA ) or ( CG9220 CG9220-PC ) or ( UDP-glycosyltransferase 37a1 CG11012-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2744" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DNA__45__LIGASE__45__ATP__45__RXN" name="DNA ligase (ATP)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5602 ) or ( Tom34 ) or ( lig3 ) or ( Lig4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5602 CG5602-PA ) or ( Translocase of outer membrane 34 CG2708-PA ) or ( CG17227 ) or ( Ligase4 CG12176-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.5.1.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
      <speciesReference species="DEOXYNUCLEOTIDESM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__KETOGLUTARATE_TO_SUC_COF_RXN" name="2-KETOGLUTARATE_TO_SUC_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__36__45__RXN" name="&amp;alpha;,&amp;alpha;-trehalose-phosphate synthase (GDP-forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tps1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Trehalose-6-phosphate synthase 1 CG4104-PA )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.36</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__3__46__2__46__9__45__RXN" name="Microsomal epoxide hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Jheh3 ) or ( Jheh2 ) or ( Jheh2 ) or ( Jheh1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Juvenile hormone epoxide hydrolase 3 CG15106-PA ) or ( Juvenile hormone epoxide hydrolase 2 CG15102-PA, isoform A ) or ( Juvenile hormone epoxide hydrolase 2 CG15102-PB, isoform B ) or ( Juvenile hormone epoxide hydrolase 1 CG15101-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8984" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8985" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCGLU__45__SEMIALDEHYDE__45__SUCCGLU__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG33092 ) or ( CG33092 ) or ( CG33092 ) or ( CG7145 ) or ( CG7145 ) or ( CG7145 ) or ( CG33092 ) or ( CG6661 ) or ( CG33092 ) or ( CG33092 ) or ( CG33092 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG33092 CG33092-PD, isoform D ) or ( CG33092 CG33092-PE, isoform E ) or ( CG33092 CG33092-PG, isoform G ) or ( CG7145 CG7145-PD, isoform D ) or ( CG7145 CG7145-PA, isoform A ) or ( CG7145 CG7145-PB, isoform B ) or ( CG33092 CG33092-PA, isoform A ) or ( CG6661 CG6661-PA ) or ( CG33092 CG33092-PB, isoform B ) or ( CG33092 CG33092-PC, isoform C ) or ( CG33092 CG33092-PF, isoform F )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__822" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N2__45__SUCCINYLGLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__67__45__RXN" name="Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pten ) or ( Pten ) or ( Pten ) or ( Pten ) or ( Pten ) or ( Pten )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pten CG5671-PC, isoform C ) or ( Pten CG5671-PD, isoform D ) or ( Pten CG5671-PB, isoform B ) or ( Pten CG5671-PE, isoform E ) or ( Pten CG5671-PA, isoform A ) or ( Pten CG5671-PF, isoform F )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.67</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYL__45__INOSITOL__45__345__45__TRISPHOSPHAT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__SULFINYL__45__PYRUVATE__45__SPON__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__SULFINYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CATECHOL__45__OXIDASE__45__RXN" name="Catechol oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dox-A2 ) or ( Dox-A3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Diphenol oxidase A2 CG10484-PA ) or ( Diphenol oxidase A3 CG2952-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CATECHOL" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__385" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPHINGOMYELIN__45__PHOSPHODIESTERASE__45__RXN" name="Sphingomyelin phosphodiesterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG3376 ) or ( CG32052 ) or ( CG15533 ) or ( CG12034 ) or ( CG15534 ) or ( CG3376 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG3376 CG3376-PA, isoform A ) or ( CG32052 CG32052-PA ) or ( CG15533 CG15533-PA ) or ( CG12034 CG12034-PA ) or ( CG15534 CG15534-PA ) or ( CG3376 CG3376-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: sphingomyelin metabolism</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.12</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PHOSPHORYL__45__CHOLINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sphingomyelins__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
      <speciesReference species="CERAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GSHTRAN__45__RXN" name="Glutathione transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG17639 ) or ( GstE10 ) or ( CG1702 ) or ( CG33177 ) or ( GstD4 ) or ( GstS1 ) or ( CG6776 ) or ( CG1681 ) or ( GstD8 ) or ( GstD2 ) or ( GstE9 ) or ( gfzf ) or ( GstD1 ) or ( GstE1 ) or ( Mgstl ) or ( CG6673 ) or ( GstE3 ) or ( GstD7 ) or ( GstD6 ) or ( GstD9 ) or ( GstE2 ) or ( GstE5 ) or ( Mgstl ) or ( GstD1 ) or ( CG11784 ) or ( CG9362 ) or ( gfzf ) or ( CG6662 ) or ( se ) or ( GstE4 ) or ( GstD3 ) or ( GstS1 ) or ( GstE6 ) or ( GstS1 ) or ( CG9363 ) or ( CG4688 ) or ( CG6673 ) or ( CG16936 ) or ( CG9363 ) or ( GstD5 ) or ( GstD10 ) or ( CG9363 ) or ( GstE7 ) or ( CG5224 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG17639 CG17639-PA ) or ( Glutathione S transferase E10 CG17522-PA ) or ( CG1702 CG1702-PA ) or ( CG33177 CG33177-PA ) or ( Glutathione S transferase D23 ) or ( Glutathione S transferase S1 CG8938-PC, isoform C ) or ( CG6776 CG6776-PA ) or ( CG1681 CG1681-PA ) or ( Glutathione S transferase D27 ) or ( Glutathione S transferase D2 CG4181-PA ) or ( Glutathione S transferase E9 CG17534-PA ) or ( GST-containing FLYWCH zinc-finger protein CG33546-PC, isoform C ) or ( CG10045 Glutathione S-transferase ) or ( Glutathione S transferase E1 CG5164-PA ) or ( Microsomal glutathione S-transferase-like CG1742-PA, isoform A ) or ( CG6673 CG6673-PA, isoform A ) or ( Glutathione S transferase E3 CG17524-PA ) or ( Glutathione S transferase D26 ) or ( Glutathione S transferase D25 ) or ( Glutathione S transferase D9 CG10091-PA ) or ( Glutathione S transferase E2 CG17523-PA ) or ( Glutathione S transferase E5 CG17527-PA ) or ( Microsomal glutathione S-transferase-like CG1742-PB, isoform B ) or ( CG10045 Glutathione S-transferase ) or ( CG11784 CG11784-PA ) or ( CG9362 CG9362-PA ) or ( GST-containing FLYWCH zinc-finger protein CG33546-PB, isoform B ) or ( CG6662 CG6662-PA ) or ( CG6781-PA ) or ( Glutathione S transferase E4 CG17525-PA ) or ( Glutathione S transferase D22 ) or ( Glutathione S transferase S1 CG8938-PB, isoform B ) or ( Glutathione S transferase E6 CG17530-PA ) or ( Glutathione S transferase S1 CG8938-PA, isoform A ) or ( CG9363 CG9363-PA, isoform A ) or ( CG4688 CG4688-PA ) or ( CG6673 CG6673-PB, isoform B ) or ( CG16936 CG16936-PA ) or ( CG9363 CG9363-PC, isoform C ) or ( Glutathione S transferase D24 ) or ( Glutathione S transferase D10 CG18548-PA ) or ( CG9363 CG9363-PB, isoform B ) or ( Glutathione S transferase E7 CG17531-PA ) or ( CG5224 CG5224-PA )</html:p>
<html:p>SUBSYSTEM: glutathione-mediated detoxification</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.18</html:p>
<html:p>SIDE: HX</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RX" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HX" stoichiometry="1"/>
      <speciesReference species="__124__S__45__Substituted__45__Glutathione__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2301" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6638 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6638 CG6638-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.10</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVALERYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PECTINESTERASE__45__RXN" name="Pectinesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG11913 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG11913 CG11913-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.11</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PECTIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PECTATE" stoichiometry="1"/>
      <speciesReference species="METOH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTARYL__45__COA__45__DEHYDROGENASE__45__RXN" name="Glutaryl-CoA dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9547 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9547 CG9547-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.7</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINATEPRIBOSYLTRANS__45__RXN" name="Nicotinate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG3714 ) or ( CG3714 ) or ( CG3714 ) or ( CG3714 ) or ( CG3714 ) or ( CG3714 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG3714 CG3714-PF, isoform F ) or ( CG3714 CG3714-PD, isoform D ) or ( CG3714 CG3714-PC, isoform C ) or ( CG3714 CG3714-PE, isoform E ) or ( CG3714 CG3714-PB, isoform B ) or ( CG3714 CG3714-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.11</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DUDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG15547 ) or ( nmdyn-D7 ) or ( awd ) or ( nmdyn-D6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG15547 CG15547-PA ) or ( nmdyn-D7 CG8362-PA ) or ( Killer of prune ) or ( nmdyn-D6 CG5310-PA )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYRIBOSE__45__P__45__ALD__45__RXN" name="Deoxyribose-phosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG8525 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG8525 CG8525-PA )</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>SUBSYSTEM: purine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXY__45__RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTDEAM__45__RXN" name="Cytosine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5292 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5292 CG5292-PA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URACIL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__26__45__RXN" name="N4-(&amp;beta;-N-acetylglucosaminyl)-L-asparaginase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG4372 ) or ( CG1827 ) or ( CG1827 ) or ( CG10474 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG4372 CG4372-PA ) or ( CG1827 CG1827-PA, isoform A ) or ( CG1827 CG1827-PB, isoform B ) or ( CG10474 CG10474-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.26</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__ETCETERA__45__L__45__ASPARAGINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="N__45__ACETYL__45__BETA__45__GLUCOSAMINYLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADDALT__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Adar ) or ( Adar ) or ( Adar )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Adenosine deaminase acting on RNA CG12598-PC, isoform C ) or ( Adenosine deaminase acting on RNA CG12598-PB, isoform B ) or ( Adenosine deaminase acting on RNA CG12598-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: purine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYINOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__METHYLTHIOADENOSINE__45__PHOSPHORYLASE__45__RXN" name="5&apos;-methylthioadenosine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG31115 ) or ( CG4802 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG31115 CG31115-PA ) or ( CG4802 CG4802-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.28</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__444" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROPIONYL__45__COA__45__CARBOXY__45__RXN" name="Propionyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG3267 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG3267 CG3267-PA )</html:p>
<html:p>SUBSYSTEM: methylmalonyl pathway</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__1OR__45__4__45__MONOPHOSPHATASE__45__RXN" name="Myo-inositol-1(or 4)-monophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG17028 ) or ( CG17026 ) or ( CG9391 ) or ( CG9389 ) or ( CG9391 ) or ( CG17027 ) or ( CG17029 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG17028 CG17028-PA ) or ( CG17026 CG17026-PA ) or ( CG9391 CG9391-PB, isoform B ) or ( CG9389 CG9389-PA ) or ( CG9391 CG9391-PA, isoform A ) or ( CG17027 CG17027-PA ) or ( CG17029 CG17029-PA )</html:p>
<html:p>SUBSYSTEM: myo-inositol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.25</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__225__45__RXN" name="N-acetylglucosaminyl-proteoglycan 4-&amp;beta;-glucuronosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ext2 ) or ( Ext2 ) or ( ttv )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG8433-PB, isoform B ) or ( CG8433-PA, isoform A ) or ( tout-velu CG10117-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.225</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8597" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8598" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALANINE__45____45__GLYOXYLATE__45__AMINOTRANSFERASE__45__RXN" name="Alanine--glyoxylate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG11241 ) or ( Spat ) or ( CG8745 ) or ( CG11241 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG11241 CG11241-PA, isoform A ) or ( Serine pyruvate aminotransferase CG3926-PA ) or ( CG8745 CG8745-PA ) or ( CG11241 CG11241-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.44</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ETHANOLAMINE__45__KINASE__45__RXN" name="Ethanolamine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG2201 ) or ( CG2201 ) or ( CG2201 ) or ( CG2201 ) or ( CG2201 ) or ( eas ) or ( eas ) or ( eas ) or ( eas ) or ( eas )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2201 CG2201-PA, isoform A ) or ( CG2201 CG2201-PB, isoform B ) or ( CG2201 CG2201-PE, isoform E ) or ( CG2201 CG2201-PC, isoform C ) or ( CG2201 CG2201-PD, isoform D ) or ( easily shocked CG3525-PA, isoform A ) or ( easily shocked CG3525-PD, isoform D ) or ( easily shocked CG3525-PE, isoform E ) or ( easily shocked CG3525-PC, isoform C ) or ( easily shocked CG3525-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: phosphatidylethanolamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.82</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETHANOL__45__AMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__162" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt36Bc ) or ( Ext2 ) or ( Ext2 ) or ( Ugt86Di ) or ( Ugt86Dd ) or ( CG5724 ) or ( CG5999 ) or ( Ugt37b1 ) or ( GlcAT-P ) or ( ttv ) or ( GlcAT-S ) or ( GlcAT-P ) or ( CG15661 ) or ( Ugt86Dh ) or ( Ugt37c1 ) or ( GlcAT-P ) or ( Ugt86Dc ) or ( Act57B ) or ( GlcAT-S ) or ( CG3797 ) or ( GlcAT-I ) or ( CG17323 ) or ( Ugt58Fa ) or ( Ugt86De ) or ( Ugt86Dg ) or ( Act57B ) or ( Ugt36Bc ) or ( Ugt36Ba ) or ( CG11289 ) or ( CG6475 ) or ( Ugt36Bb ) or ( Ugt35b ) or ( CG4302 ) or ( CG31002 ) or ( Ugt35a ) or ( CG15661 ) or ( CG10178 ) or ( Ugt86Dj ) or ( Ugt86Da ) or ( CG9220 ) or ( Ugt37a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ugt36Bc CG17932-PB, isoform B ) or ( CG8433-PA, isoform A ) or ( CG8433-PB, isoform B ) or ( Ugt86Di CG6658-PA ) or ( Ugt86Dd CG6633-PB ) or ( CG5724 CG5724-PA ) or ( CG5999 CG5999-PA ) or ( UDP-glycosyltransferase 37b1 CG9481-PA ) or ( GlcAT-P CG6207-PC, isoform C ) or ( tout-velu CG10117-PA ) or ( GlcAT-S CG3881-PB, isoform B ) or ( GlcAT-P CG6207-PB, isoform B ) or ( CG15661 CG15661-PA, isoform A ) or ( Ugt86Dh CG4772-PA ) or ( UDP-glycosyltransferase 37c1 CG8652-PA ) or ( GlcAT-P CG6207-PA, isoform A ) or ( Ugt86Dc CG4739-PA ) or ( Actin 57B CG10067-PB, isoform B ) or ( GlcAT-S CG3881-PA, isoform A ) or ( CG3797 CG3797-PA ) or ( GlcAT-I CG32775-PA ) or ( CG17323 CG17323-PA ) or ( Ugt58Fa CG4414-PA ) or ( Ugt86De CG6653-PA ) or ( Ugt86Dg CG17200-PA ) or ( Actin 57B CG10067-PA, isoform A ) or ( Ugt36Bc CG17932-PA, isoform A ) or ( Ugt36Ba CG13270-PA ) or ( CG11289 CG11289-PA ) or ( CG6475 CG6475-PB ) or ( Ugt36Bb CG13271-PA ) or ( UDP-glycosyltransferase ) or ( CG4302 CG4302-PA ) or ( CG31002 CG31002-PA ) or ( UDP-glycosyltransferase 35a CG6644-PA ) or ( CG15661 CG15661-PB, isoform B ) or ( CG10178 CG10178-PA ) or ( Ugt86Dj CG15902-PA ) or ( Ugt86Da CG18578-PA ) or ( CG9220 CG9220-PC ) or ( UDP-glycosyltransferase 37a1 CG11012-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2750" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2752" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TREHALA__45__RXN" name="&amp;alpha;,&amp;alpha;-trehalase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6262 ) or ( Treh ) or ( CG6262 ) or ( CG6262 ) or ( CG16965 ) or ( Treh ) or ( CG6262 ) or ( CG6262 ) or ( Treh ) or ( Treh ) or ( Treh ) or ( Treh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6262 CG6262-PE, isoform E ) or ( Trehalase CG9364-PF, isoform F ) or ( CG6262 CG6262-PC, isoform C ) or ( CG6262 CG6262-PD, isoform D ) or ( CG16965 CG16965-PA ) or ( Trehalase CG9364-PB, isoform B ) or ( CG6262 CG6262-PB, isoform B ) or ( CG6262 CG6262-PA, isoform A ) or ( Trehalase CG9364-PA, isoform A ) or ( Trehalase CG9364-PC, isoform C ) or ( Trehalase CG9364-PE, isoform E ) or ( Trehalase CG9364-PD, isoform D )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.28</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="PORPHOBILSYNTH__45__RXN" name="Porphobilinogen synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pbgs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Porphobilinogen synthase CG10335-PA )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.24</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PORPHOBILINOGEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8036" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG33090 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG33090 CG33090-PB )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.21</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7417" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7418" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8728" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ipk2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ipk2 CG13688-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.151</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1456__45__TETRAKISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1107" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTMPKI__45__RXN" name="Thymidylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5757 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5757 CG5757-PA )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__168" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt36Bc ) or ( Ext2 ) or ( Ext2 ) or ( Ugt86Di ) or ( Ugt86Dd ) or ( CG5724 ) or ( CG5999 ) or ( Ugt37b1 ) or ( GlcAT-P ) or ( ttv ) or ( GlcAT-S ) or ( GlcAT-P ) or ( CG15661 ) or ( Ugt86Dh ) or ( Ugt37c1 ) or ( GlcAT-P ) or ( Ugt86Dc ) or ( Act57B ) or ( GlcAT-S ) or ( CG3797 ) or ( GlcAT-I ) or ( CG17323 ) or ( Ugt58Fa ) or ( Ugt86De ) or ( Ugt86Dg ) or ( Act57B ) or ( Ugt36Bc ) or ( Ugt36Ba ) or ( CG11289 ) or ( CG6475 ) or ( Ugt36Bb ) or ( Ugt35b ) or ( CG4302 ) or ( CG31002 ) or ( Ugt35a ) or ( CG15661 ) or ( CG10178 ) or ( Ugt86Dj ) or ( Ugt86Da ) or ( CG9220 ) or ( Ugt37a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ugt36Bc CG17932-PB, isoform B ) or ( CG8433-PA, isoform A ) or ( CG8433-PB, isoform B ) or ( Ugt86Di CG6658-PA ) or ( Ugt86Dd CG6633-PB ) or ( CG5724 CG5724-PA ) or ( CG5999 CG5999-PA ) or ( UDP-glycosyltransferase 37b1 CG9481-PA ) or ( GlcAT-P CG6207-PC, isoform C ) or ( tout-velu CG10117-PA ) or ( GlcAT-S CG3881-PB, isoform B ) or ( GlcAT-P CG6207-PB, isoform B ) or ( CG15661 CG15661-PA, isoform A ) or ( Ugt86Dh CG4772-PA ) or ( UDP-glycosyltransferase 37c1 CG8652-PA ) or ( GlcAT-P CG6207-PA, isoform A ) or ( Ugt86Dc CG4739-PA ) or ( Actin 57B CG10067-PB, isoform B ) or ( GlcAT-S CG3881-PA, isoform A ) or ( CG3797 CG3797-PA ) or ( GlcAT-I CG32775-PA ) or ( CG17323 CG17323-PA ) or ( Ugt58Fa CG4414-PA ) or ( Ugt86De CG6653-PA ) or ( Ugt86Dg CG17200-PA ) or ( Actin 57B CG10067-PA, isoform A ) or ( Ugt36Bc CG17932-PA, isoform A ) or ( Ugt36Ba CG13270-PA ) or ( CG11289 CG11289-PA ) or ( CG6475 CG6475-PB ) or ( Ugt36Bb CG13271-PA ) or ( UDP-glycosyltransferase ) or ( CG4302 CG4302-PA ) or ( CG31002 CG31002-PA ) or ( UDP-glycosyltransferase 35a CG6644-PA ) or ( CG15661 CG15661-PB, isoform B ) or ( CG10178 CG10178-PA ) or ( Ugt86Dj CG15902-PA ) or ( Ugt86Da CG18578-PA ) or ( CG9220 CG9220-PC ) or ( UDP-glycosyltransferase 37a1 CG11012-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2747" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5184" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GlyP ) or ( CG16965 ) or ( GlyP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glycogen phosphorylase CG7254-PA, isoform A ) or ( CG16965 CG16965-PA ) or ( Glycogen phosphorylase CG7254-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACCASE__45__RXN" name="Laccase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG32838 ) or ( CG32557 ) or ( CG30437 ) or ( CG30437 ) or ( CG30437 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG32838 CG32838-PA ) or ( CG32557 CG32557-PA ) or ( CG30437 CG30437-PA, isoform A ) or ( CG30437 CG30437-PC, isoform C ) or ( CG30437 CG30437-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CATECHOL" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZOSEMIQUINONE" stoichiometry="4"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5183" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG11909 ) or ( LvpD ) or ( CG6453 ) or ( CG7685 ) or ( CG14935 ) or ( CG14934 ) or ( CG14476 ) or ( CG11669 ) or ( CG14476 ) or ( CG8690 ) or ( CG8693 ) or ( CG33080 ) or ( CG33080 ) or ( CG14935 ) or ( LvpH ) or ( LvpL ) or ( CG14476 ) or ( CG14476 ) or ( CG14476 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG11909 CG11909-PA ) or ( Larval visceral protein D CG8694-PA ) or ( CG6453 CG6453-PA ) or ( CG7685 CG7685-PA ) or ( CG14935 CG14935-PA, isoform A ) or ( CG14934 CG14934-PA ) or ( CG14476 CG14476-PB, isoform B ) or ( CG11669 CG11669-PA ) or ( CG14476 CG14476-PC, isoform C ) or ( CG8690 CG8690-PA ) or ( CG8693 CG8693-PA ) or ( CG33080 CG33080-PB, isoform B ) or ( CG33080 CG33080-PA, isoform A ) or ( CG14935 CG14935-PB, isoform B ) or ( Larval visceral protein H CG8696-PA ) or ( Larval visceral protein L CG8695-PA ) or ( CG14476 CG14476-PA, isoform A ) or ( CG14476 CG14476-PD, isoform D ) or ( CG14476 CG14476-PE, isoform E )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.20</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOTRIOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__140__45__RXN" name="1D-myo-inositol-tetrakisphosphate 5-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ipk2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ipk2 CG13688-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.140</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__505" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1107" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TYROSINE__45__ESTER__45__SULFOTRANSFERASE__45__RXN" name="Tyrosine-ester sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5431 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5431 CG5431-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.9</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__TYROSINE__45__METHYL__45__ESTER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__TYROSINE__45__METHYL__45__ESTER__45__4__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5182" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GlyP ) or ( CG16965 ) or ( GlyP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glycogen phosphorylase CG7254-PA, isoform A ) or ( CG16965 CG16965-PA ) or ( Glycogen phosphorylase CG7254-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOTRIOSE" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__46__45__RXN" name="Fructose-2,6-bisphosphate 2-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pfrx ) or ( Pfrx ) or ( Pfrx ) or ( Pfrx ) or ( Pfrx ) or ( Pfrx ) or ( Pfrx ) or ( Pfrx )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphofructo-2-kinase CG3400-PH, isoform H ) or ( 6-phosphofructo-2-kinase CG3400-PD, isoform D ) or ( 6-phosphofructo-2-kinase CG3400-PE, isoform E ) or ( 6-phosphofructo-2-kinase CG3400-PF, isoform F ) or ( 6-phosphofructo-2-kinase CG3400-PI, isoform I ) or ( 6-phosphofructo-2-kinase CG3400-PA, isoform A ) or ( 6-phosphofructo-2-kinase CG3400-PB, isoform B ) or ( 6-phosphofructo-2-kinase CG3400-PG, isoform G )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.46</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__535" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5181" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Amy-d ) or ( Amy-p ) or ( Amyrel )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Amylase distal CG17876-PA ) or ( Amylase proximal CG18730-PA ) or ( Amyrel CG8221-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOHEXAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTAGLY__45__RXN" name="Cystathionine &amp;gamma;-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG12264 ) or ( Eip55E )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG12264 CG12264-PA ) or ( Eip55E CG5345-PA )</html:p>
<html:p>SUBSYSTEM: homocysteine degradation</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R311__45__RXN" name="Amidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7910 ) or ( CG5191 ) or ( CG8839 ) or ( gatA ) or ( CG5191 ) or ( CG5191 ) or ( CG8839 ) or ( CG5191 ) or ( CG5191 ) or ( PGRP-LB ) or ( PGRP-LB ) or ( CG5112 ) or ( CG8839 ) or ( CG7900 ) or ( CG8839 ) or ( PGRP-LB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7910 CG7910-PA ) or ( CG5191 CG5191-PD, isoform D ) or ( CG8839 CG8839-PC, isoform C ) or ( benedict ) or ( CG5191 CG5191-PC, isoform C ) or ( CG5191 CG5191-PA, isoform A ) or ( CG8839 CG8839-PD, isoform D ) or ( CG5191 CG5191-PB, isoform B ) or ( CG5191 CG5191-PE, isoform E ) or ( Peptidoglycan recognition protein LB CG14704-PB, isoform B ) or ( Peptidoglycan recognition protein LB CG14704-PA, isoform A ) or ( CG5112 CG5112-PA ) or ( CG8839 CG8839-PA, isoform A ) or ( CG7900 CG7900-PB ) or ( CG8839 CG8839-PE, isoform E ) or ( Peptidoglycan recognition protein LB CG14704-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACRYLAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACRYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDOSE__45__1__45__EPIMERASE__45__RXN" name="Aldose 1-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9008 ) or ( CG10996 ) or ( CG32445 ) or ( CG4988 ) or ( CG10467 ) or ( CG9008 ) or ( CG32444 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9008 CG9008-PB, isoform B ) or ( CG10996 CG10996-PA ) or ( CG32445 CG32445-PA ) or ( CG4988 CG4988-PA ) or ( CG10467 CG10467-PA ) or ( CG9008 CG9008-PA, isoform A ) or ( CG32444 CG32444-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__11417" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sk1 ) or ( Sk2 ) or ( Sk1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Sphingosine kinase 1 CG1747-PA, isoform A ) or ( Sphingosine kinase 2 CG32484-PA ) or ( Sphingosine kinase 1 CG1747-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: sphingosine and sphingosine-1-phosphate metabolism</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPHINGOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3DJ__45__11366" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRROLINECARBREDUCT__45__RXN" name="Pyrroline-5-carboxylate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( P5cr ) or ( CG5840 ) or ( CG5840 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pyrroline 5-carboyxlate reductase CG6009-PA ) or ( CG5840 CG5840-PA, isoform A ) or ( CG5840 CG5840-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis II</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__114__45__RXN" name="Hexaprenyldihydroxybenzoate methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9249 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9249 CG9249-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.114</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HEXAPRENYL__45__45__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HEXAPRENYL__45__4__45__HYDROXY__45__5__45__METHOXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPCARBTRANS__45__RXN" name="Aspartate carbamoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( r ) or ( r )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( rudimentary CG18572-PA, isoform A ) or ( rudimentary CG18572-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: uridine-5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.2</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMYUL__45__L__45__ASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTEINE__45__DIOXYGENASE__45__RXN" name="Cysteine dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5493 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5493 CG5493-PA )</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation I</html:p>
<html:p>SUBSYSTEM: taurine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.20</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__SULFINOALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__3" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9629 ) or ( CG31075 ) or ( Aldh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9629 CG9629-PA ) or ( CG31075 CG31075-PA ) or ( Aldehyde dehydrogenase CG3752-PA )</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation III</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__1" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Irc ) or ( CG9314 ) or ( Cat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Immune-regulated catalase CG8913-PA ) or ( CG9314 CG9314-PA ) or ( Catalase CG6871-PA )</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.6</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8442" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG16758 ) or ( CG16758 ) or ( CG16758 ) or ( CG16758 ) or ( CG18128 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG16758 CG16758-PE, isoform E ) or ( CG16758 CG16758-PD, isoform D ) or ( CG16758 CG16758-PB, isoform B ) or ( CG16758 CG16758-PF, isoform F ) or ( CG18128 CG18128-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINE" stoichiometry="1"/>
      <speciesReference species="D__45__RIBULOSE__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8259" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3902" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9547 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9547 CG9547-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BIS5__45__ADENOSYL__45__TRIPHOSPHATASE__45__RXN" name="Bis(5&apos;-adenosyl)-triphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NitFhit )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nitrilase and fragile histidine triad fusion protein CG7067-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.29</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE5TRIPHOSPHO5ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGSUCCINLYA__45__RXN" name="Argininosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9510 ) or ( CG9510 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9510-PB, isoform B ) or ( CG9510-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: citrulline-nitric oxide cycle</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.1</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ARGININO__45__SUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ARG" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AIRCARBOXY__45__RXN" name="Phosphoribosylaminoimidazole carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG17024 ) or ( ade5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG17024 CG17024-PA ) or ( ade5 CG3989-PA )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.21</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6841" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( l(2)k05713 ) or ( l(2)k05713 ) or ( l(2)k05713 ) or ( CG7311 ) or ( CG31169 ) or ( Dhc36C ) or ( CG8046 ) or ( CG31169 ) or ( l(2)k05713 ) or ( CG2137 ) or ( Gpdh ) or ( Gpdh ) or ( CG8046 ) or ( CG3215 ) or ( Gpdh ) or ( CG7311 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lethal (2) k05713 CG8256-PA, isoform A ) or ( lethal (2) k05713 CG8256-PC, isoform C ) or ( lethal (2) k05713 CG8256-PB, isoform B ) or ( CG7311 CG7311-PB, isoform B ) or ( CG31169 CG31169-PA, isoform A ) or ( Dynein heavy chain at 36C CG5526-PA ) or ( CG8046 CG8046-PB, isoform B ) or ( CG31169 CG31169-PB, isoform B ) or ( lethal (2) k05713 CG8256-PD, isoform D ) or ( CG2137 CG2137-PA ) or ( Glycerol 3 phosphate dehydrogenase CG9042-PC, isoform C ) or ( Glycerol 3 phosphate dehydrogenase CG9042-PB, isoform B ) or ( CG8046 CG8046-PA, isoform A ) or ( CG3215 CG3215-PA ) or ( Glycerol 3 phosphate dehydrogenase CG9042-PA, isoform A ) or ( CG7311 CG7311-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXII__45__RXN" name="Hydroxyacylglutathione hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG4365 ) or ( CG4365 ) or ( CG4365 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG4365 CG4365-PC, isoform C ) or ( CG4365 CG4365-PA, isoform A ) or ( CG4365 CG4365-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__LACTOYL__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__1__45__PHOSPHATE__45__SYNTHASE__45__RXN" name="myo-inositol-1-phosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Inos )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Inos CG11143-PA )</html:p>
<html:p>SUBSYSTEM: myo-inositol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__709" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7724 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7724 CG7724-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__707" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__708" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLCHOLINESTERASE__45__RXN" name="Acetylcholinesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ace )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acetylcholine esterase CG17907-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7699" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6984 ) or ( CG6543 ) or ( CG8778 ) or ( CG6543 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6984 CG6984-PA ) or ( CG6543 CG6543-PA, isoform A ) or ( CG8778 CG8778-PA ) or ( CG6543 CG6543-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: very long chain fatty acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__214__45__RXN" name="Glycoprotein 3-&amp;alpha;-L-fucosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FucTA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( FucTA CG6869-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.214</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N4__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__12" stoichiometry="1"/>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N4__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__F" stoichiometry="1"/>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLYCDEHYDROG__45__RXN" name="Phosphoglycerate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1236 ) or ( CG6287 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1236 CG1236-PA ) or ( CG6287 CG6287-PA )</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.95</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__P__45__HYDROXYPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTCYSLIG__45__RXN" name="Glutamate--cysteine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gclc ) or ( Gclc ) or ( wfs1 ) or ( wfs1 ) or ( Gclm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glutamate-cysteine ligase catalytic subunit CG2259-PA, isoform A ) or ( Glutamate-cysteine ligase catalytic subunit CG2259-PB, isoform B ) or ( wolfram syndrome 1 CG4917-PA, isoform A ) or ( wolfram syndrome 1 CG4917-PB, isoform B ) or ( Glutamate-cysteine ligase modifier subunit CG4919-PA )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>SUBSYSTEM: glutathione biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GAMMA__45__GLUTAMYLCYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7698" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( scu )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( scully CG7113-PA )</html:p>
<html:p>SUBSYSTEM: very long chain fatty acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.36</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__125__45__RXN" name="Histone-arginine N-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Art4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Arginine methyltransferase 4 CG5358-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.125</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Histone__45__L__45__arginines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Histone__45__N__45__o__45__methyl__45__arginines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALEYLACETOACETATE__45__ISOMERASE__45__RXN" name="Maleylacetoacetate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9363 ) or ( CG9363 ) or ( CG9363 ) or ( CG9362 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9363 CG9363-PA, isoform A ) or ( CG9363 CG9363-PC, isoform C ) or ( CG9363 CG9363-PB, isoform B ) or ( CG9362 CG9362-PA )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.2.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__MALEYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__FUMARYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TYROSINE__45__DECARBOXYLASE__45__RXN" name="Tyrosine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tdc1 ) or ( Tdc2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Tyrosine decarboxylase 1 CG30445-PA ) or ( Tyrosine decarboxylase 2 CG30446-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.25</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TYRAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6021" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG18814 ) or ( Adh ) or ( Fdh ) or ( Adh ) or ( Adh ) or ( Adh ) or ( Fbp2 ) or ( Adh ) or ( T3dh ) or ( CG4842 ) or ( Pdh ) or ( Pdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG18814 CG18814-PA ) or ( CG3481-PE, isoform E ) or ( Formaldehyde dehydrogenase CG6598-PA ) or ( CG3481-PC, isoform C ) or ( CG3481-PI, isoform I ) or ( CG3481-PH, isoform H ) or ( Fat body protein 2 CG3763-PA ) or ( CG3481-PF, isoform F ) or ( Type III alcohol dehydrogenase CG3425-PA ) or ( CG4842 CG4842-PA ) or ( Photoreceptor dehydrogenase CG4899-PA, isoform A ) or ( Photoreceptor dehydrogenase CG4899-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__7__45__RXN" name="Saccharopine dehydrogenase (NAD+, L-lysine forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7144 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7144 CG7144-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.7</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SACCHAROPINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CERAMIDASE__45__RXN" name="Ceramidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CDase ) or ( CDase ) or ( CDase ) or ( bwa ) or ( CDase ) or ( CDase )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ceramidase CG1471-PB, isoform B ) or ( Ceramidase CG1471-PC, isoform C ) or ( Ceramidase CG1471-PA, isoform A ) or ( brain washing CG13969-PA ) or ( Ceramidase CG1471-PD, isoform D ) or ( Ceramidase CG1471-PE, isoform E )</html:p>
<html:p>SUBSYSTEM: sphingosine and sphingosine-1-phosphate metabolism</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.23</html:p>
<html:p>SIDE: __124__Carboxylates__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="SPHINGOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMPSYN__45__RXN" name="Adenylosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG3590 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG3590 CG3590-PA )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.2</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENYLOSUCC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__LACTATE__45__DEHYDROGENASE__45__RXN" name="L-lactate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG10748 ) or ( ImpL3 ) or ( CG13334 ) or ( CG5362 ) or ( CG7998 ) or ( CG10749 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG10748 CG10748-PA ) or ( Ecdysone-inducible gene L3 CG10160-PA ) or ( CG13334 CG13334-PA ) or ( CG5362 CG5362-PA ) or ( CG7998 CG7998-PA ) or ( CG10749 CG10749-PA )</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to lactate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.27</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__68__45__RXN" name="Glycoprotein 6-&amp;alpha;-L-fucosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FucT6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha1,6-fucosyltransferase CG2448-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.68</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N4__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__12" stoichiometry="1"/>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N4__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__F6" stoichiometry="1"/>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROGENIIISYN__45__RXN" name="uroporphyrinogen-III synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9589 ) or ( CG1885 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9589 CG9589-PA ) or ( CG1885 CG1885-PA )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.75</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXYMETHYLBILANE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_10__45__FORMYL__45__THF_TO_THF_COF_RXN" name="10-FORMYL-THF_TO_THF_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="_10__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5199" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG16758 ) or ( CG16758 ) or ( CG16758 ) or ( CG16758 ) or ( CG18128 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG16758 CG16758-PD, isoform D ) or ( CG16758 CG16758-PE, isoform E ) or ( CG16758 CG16758-PB, isoform B ) or ( CG16758 CG16758-PF, isoform F ) or ( CG18128 CG18128-PA )</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROPCOASYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Arc42 ) or ( CG4860 ) or ( CG5009 ) or ( Acox57D-d ) or ( Acox57D-p ) or ( CG4586 ) or ( CG17544 ) or ( CG12262 ) or ( CG17544 ) or ( CG9527 ) or ( CG17544 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Arc42 CG4703-PA ) or ( CG4860 CG4860-PA ) or ( CG5009 CG5009-PA ) or ( acyl-Coenzyme A oxidase at 57D distal CG9709-PA ) or ( acyl-Coenzyme A oxidase at 57D proximal CG9707-PA ) or ( CG4586 CG4586-PA ) or ( CG17544 CG17544-PC, isoform C ) or ( CG12262 CG12262-PA ) or ( CG17544 CG17544-PB, isoform B ) or ( CG9527 CG9527-PA ) or ( CG17544 CG17544-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.3</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACRYLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1105" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG8834 ) or ( CG4563 ) or ( CG8834 ) or ( CG9993 ) or ( CG11453 ) or ( CG5568 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG8834 CG8834-PB, isoform B ) or ( CG4563 CG4563-PA ) or ( CG8834 CG8834-PA, isoform A ) or ( CG9993 CG9993-PA ) or ( CG11453 CG11453-PA ) or ( CG5568 CG5568-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.12</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="FERULIC__45__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FERULOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSACETYLGLUCOSAMINEMUT__45__RXN" name="Phosphoacetylglucosamine mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG10627 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG10627 CG10627-PA )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP__45__CYCLOHYDRO__45__I__45__RXN" name="GTP cyclohydrolase I" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pu ) or ( Pu ) or ( Pu ) or ( T3dh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Punch CG9441-PB, isoform B ) or ( Punch CG9441-PA, isoform A ) or ( Punch CG9441-PC, isoform C ) or ( Type III alcohol dehydrogenase CG3425-PA )</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.16</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDRONEOPTERIN__45__P3" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__2__46__1__46__33__45__RXN" name="Amylo-1,6-glucosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9485 ) or ( CG9485 ) or ( CG9485 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9485 CG9485-PA, isoform A ) or ( CG9485 CG9485-PB, isoform B ) or ( CG9485 CG9485-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.33</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Truncated__45__Limit__45__Dextrins__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1027" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROFOLATEREDUCT__45__RXN" name="Dihydrofolate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dhfr ) or ( Dhfr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dihydrofolate reductase CG14887-PA, isoform A ) or ( Dihydrofolate reductase CG14887-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.3</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOLIPASE__45__A2__45__RXN" name="Phospholipase A2" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sPLA2 ) or ( Egfr ) or ( CG10133 ) or ( CG6718 ) or ( SK ) or ( SK ) or ( DNApol-delta ) or ( SK ) or ( rad ) or ( GIIIspla2 ) or ( GXIVsPLA2 ) or ( SK ) or ( CG3009 ) or ( SK ) or ( GXIVsPLA2 ) or ( SK ) or ( Egfr ) or ( SK ) or ( CG6718 ) or ( sPLA2 ) or ( CG6718 ) or ( CG6718 ) or ( CG32741 ) or ( CG30184 ) or ( sPLA2 ) or ( CG7351 ) or ( CG14507 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( secretory Phospholipase A2 CG11124-PB, isoform B ) or ( Epidermal growth factor receptor CG10079-PB, isoform B ) or ( CG10133 CG10133-PA ) or ( CG6718 CG6718-PD, isoform D ) or ( small conductance calcium-activated potassium channel CG10706-PE, isoform E ) or ( small conductance calcium-activated potassium channel CG10706-PG, isoform G ) or ( DNA-polymerase-delta CG5949-PA ) or ( small conductance calcium-activated potassium channel CG10706-PB, isoform B ) or ( radish CG4346-PA ) or ( CG1583 CG1583-PA ) or ( GXIVsPLA2 CG17035-PA, isoform A ) or ( small conductance calcium-activated potassium channel CG10706-PD, isoform D ) or ( CG3009 CG3009-PA ) or ( small conductance calcium-activated potassium channel CG10706-PC, isoform C ) or ( GXIVsPLA2 CG17035-PB, isoform B ) or ( small conductance calcium-activated potassium channel CG10706-PA, isoform A ) or ( Epidermal growth factor receptor CG10079-PA, isoform A ) or ( small conductance calcium-activated potassium channel CG10706-PF, isoform F ) or ( CG6718 CG6718-PA, isoform A ) or ( secretory Phospholipase A2 CG11124-PC, isoform C ) or ( CG6718 CG6718-PB, isoform B ) or ( CG6718 CG6718-PC, isoform C ) or ( CG32741 CG32741-PA ) or ( CG30184 CG30184-PA ) or ( secretory Phospholipase A2 CG11124-PA, isoform A ) or ( CG7351 CG7351-PA ) or ( CG14507 CG14507-PC )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.4</html:p>
<html:p>SIDE: __124__Carboxylates__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYMETHYLGLUTARYL__45__COA__45__SYNTHASE__45__RXN" name="Hydroxymethylglutaryl-CoA synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hmgs ) or ( Hmgs ) or ( Hmgs ) or ( Hmgs ) or ( Hmgs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( HMG Coenzyme A synthase CG4311-PB, isoform B ) or ( HMG Coenzyme A synthase CG4311-PC, isoform C ) or ( HMG Coenzyme A synthase CG4311-PA, isoform A ) or ( HMG Coenzyme A synthase CG4311-PD, isoform D ) or ( HMG Coenzyme A synthase CG4311-PE, isoform E )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.10</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__11__45__RXN" name="Glycogen (starch) synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6904 ) or ( CG6904 ) or ( CG6904 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6904 CG6904-PC, isoform C ) or ( CG6904 CG6904-PA, isoform A ) or ( CG6904 CG6904-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.11</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALPHA__45__AMYL__45__RXN" name="&amp;alpha;-amylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Amy-d ) or ( Amy-p ) or ( Amyrel )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Amylase distal CG17876-PA ) or ( Amylase proximal CG18730-PA ) or ( Amyrel CG8221-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOPENTAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1381" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5508 ) or ( CG5508 ) or ( Dhap-at ) or ( CG5508 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5508 CG5508-PC, isoform C ) or ( CG5508 CG5508-PA, isoform A ) or ( Dihydroxyacetone phosphate acyltransferase CG4625-PA ) or ( CG5508 CG5508-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: triacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis II</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.15</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACYL__45__SN__45__GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7693" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG18814 ) or ( Adh ) or ( Fdh ) or ( Adh ) or ( Adh ) or ( Adh ) or ( Fbp2 ) or ( Adh ) or ( T3dh ) or ( CG4842 ) or ( Pdh ) or ( Pdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG18814 CG18814-PA ) or ( CG3481-PE, isoform E ) or ( Formaldehyde dehydrogenase CG6598-PA ) or ( CG3481-PC, isoform C ) or ( CG3481-PI, isoform I ) or ( CG3481-PH, isoform H ) or ( Fat body protein 2 CG3763-PA ) or ( CG3481-PF, isoform F ) or ( Type III alcohol dehydrogenase CG3425-PA ) or ( CG4842 CG4842-PA ) or ( Photoreceptor dehydrogenase CG4899-PA, isoform A ) or ( Photoreceptor dehydrogenase CG4899-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: leucine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7031" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7032" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7694" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG18814 ) or ( Adh ) or ( Fdh ) or ( Adh ) or ( Adh ) or ( Adh ) or ( Fbp2 ) or ( Adh ) or ( T3dh ) or ( CG4842 ) or ( Pdh ) or ( Pdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG18814 CG18814-PA ) or ( CG3481-PE, isoform E ) or ( Formaldehyde dehydrogenase CG6598-PA ) or ( CG3481-PC, isoform C ) or ( CG3481-PI, isoform I ) or ( CG3481-PH, isoform H ) or ( Fat body protein 2 CG3763-PA ) or ( CG3481-PF, isoform F ) or ( Type III alcohol dehydrogenase CG3425-PA ) or ( CG4842 CG4842-PA ) or ( Photoreceptor dehydrogenase CG4899-PA, isoform A ) or ( Photoreceptor dehydrogenase CG4899-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLBUT__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7033" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__17__45__RXN" name="Calcium/calmodulin-dependent protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Strn-Mlck ) or ( Strn-Mlck ) or ( Strn-Mlck ) or ( Strn-Mlck ) or ( Strn-Mlck ) or ( CaMKI ) or ( CaMKI ) or ( Strn-Mlck ) or ( CaMKI ) or ( CaMKI ) or ( CG17698 ) or ( CG17698 ) or ( CaMKI ) or ( Caki ) or ( Caki ) or ( Caki ) or ( Caki ) or ( CaMKI ) or ( CaMKII ) or ( CaMKII ) or ( CaMKII ) or ( CaMKII ) or ( CaMKII ) or ( Caki ) or ( CaMKI ) or ( CG17698 ) or ( CaMKII ) or ( Strn-Mlck )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Stretchin-Mlck CG18255-PC, isoform C ) or ( Stretchin-Mlck CG18255-PF, isoform F ) or ( Stretchin-Mlck CG18255-PB, isoform B ) or ( Stretchin-Mlck CG18255-PG, isoform G ) or ( Stretchin-Mlck CG18255-PD, isoform D ) or ( Calcium/calmodulin-dependent protein kinase I CG1495-PA, isoform A ) or ( Calcium/calmodulin-dependent protein kinase I CG1495-PE, isoform E ) or ( Stretchin-Mlck CG18255-PE, isoform E ) or ( Calcium/calmodulin-dependent protein kinase I CG1495-PH, isoform H ) or ( Calcium/calmodulin-dependent protein kinase I CG1495-PC, isoform C ) or ( CG17698 CG17698-PB, isoform B ) or ( CG17698 CG17698-PC, isoform C ) or ( Calcium/calmodulin-dependent protein kinase I CG1495-PB, isoform B ) or ( Calcium/calmodulin-dependent protein kinase CG6703-PE, isoform E ) or ( Calcium/calmodulin-dependent protein kinase CG6703-PA, isoform A ) or ( Calcium/calmodulin-dependent protein kinase CG6703-PD, isoform D ) or ( Calcium/calmodulin-dependent protein kinase CG6703-PB, isoform B ) or ( Calcium/calmodulin-dependent protein kinase I CG1495-PG, isoform G ) or ( Calcium/calmodulin-dependent protein kinase II CG18069-PC, isoform C ) or ( Calcium/calmodulin-dependent protein kinase II CG18069-PG, isoform G ) or ( Calcium/calmodulin-dependent protein kinase II CG18069-PB, isoform B ) or ( Calcium/calmodulin-dependent protein kinase II CG18069-PD, isoform D ) or ( Calcium/calmodulin-dependent protein kinase II CG18069-PE, isoform E ) or ( Calcium/calmodulin-dependent protein kinase CG6703-PC, isoform C ) or ( Calcium/calmodulin-dependent protein kinase I CG1495-PD, isoform D ) or ( CG17698 CG17698-PA, isoform A ) or ( Calcium/calmodulin-dependent protein kinase II CG18069-PA, isoform A ) or ( Stretchin-Mlck CG18255-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVINSYNDEAM__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RluA-1 ) or ( RluA-1 ) or ( RluA-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( RluA-1 CG31719-PC, isoform C ) or ( RluA-1 CG31719-PB, isoform B ) or ( RluA-1 CG31719-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.26</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIAMINO__45__OH__45__PHOSPHORIBOSYLAMINO__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__602" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDEAM__45__RXN" name="Cytidine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG8360 ) or ( CG8353 ) or ( CG8349 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG8360 CG8360-PA ) or ( CG8353 CG8353-PA ) or ( CG8349 CG8349-PA )</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYCYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYURIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSAMINEPNACETYLTRANS__45__RXN" name="Glucosamine-phosphate N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1969 ) or ( CG1969 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1969 CG1969-PA, isoform A ) or ( CG1969 CG1969-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.4</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DUTP__45__PYROP__45__RXN" name="dUTP pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dUTPase ) or ( dUTPase )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Deoxyuridine triphosphatase CG4584-PA, isoform A ) or ( Deoxyuridine triphosphatase CG4584-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.23</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLCOASYN__45__RXN" name="long-chain-fatty-acid--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6178 ) or ( CG3961 ) or ( CG9009 ) or ( CG3961 ) or ( l(2)44DEa ) or ( l(2)44DEa ) or ( CG3961 ) or ( CG18155 ) or ( CG4500 ) or ( l(2)44DEa ) or ( l(2)44DEa ) or ( CG18155 ) or ( l(2)44DEa ) or ( l(2)44DEa ) or ( l(2)44DEa ) or ( l(2)44DEa ) or ( l(2)44DEa ) or ( bgm ) or ( CG12512 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6178 CG6178-PA ) or ( CG3961 CG3961-PA, isoform A ) or ( CG9009 CG9009-PA ) or ( CG3961 CG3961-PC, isoform C ) or ( lethal (2) 44DEa CG8732-PD, isoform D ) or ( lethal (2) 44DEa CG8732-PI, isoform I ) or ( CG3961 CG3961-PB, isoform B ) or ( CG18155 CG18155-PA, isoform A ) or ( CG4500 CG4500-PA ) or ( lethal (2) 44DEa CG8732-PB, isoform B ) or ( lethal (2) 44DEa CG8732-PE, isoform E ) or ( CG18155 CG18155-PB, isoform B ) or ( lethal (2) 44DEa CG8732-PA, isoform A ) or ( lethal (2) 44DEa CG8732-PC, isoform C ) or ( lethal (2) 44DEa CG8732-PH, isoform H ) or ( lethal (2) 44DEa CG8732-PG, isoform G ) or ( lethal (2) 44DEa CG8732-PF, isoform F ) or ( bubblegum CG4501-PA ) or ( CG12512 CG12512-PA )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation II (core pathway)</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9023" name="disproportionating enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9485 ) or ( CG9485 ) or ( CG9485 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9485 CG9485-PA, isoform A ) or ( CG9485 CG9485-PB, isoform B ) or ( CG9485 CG9485-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.25</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__971" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Truncated__45__Limit__45__Dextrins__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPGLUCDEHYDRAT__45__RXN" name="dTDP-glucose 4,6-dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7979 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7979 CG7979-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.46</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9025" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GlyP ) or ( CG16965 ) or ( GlyP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glycogen phosphorylase CG7254-PA, isoform A ) or ( CG16965 CG16965-PA ) or ( Glycogen phosphorylase CG7254-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1027" stoichiometry="1"/>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__971" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUMARYLACETOACETASE__45__RXN" name="Fumarylacetoacetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Faa )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Fumarylacetoacetase CG14993-PA )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__FUMARYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENOSYLHOMOCYSTEINASE__45__RXN" name="Adenosylhomocysteinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9977 ) or ( Ahcy89E ) or ( Ahcy89E ) or ( Ahcy13 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9977 CG9977-PA ) or ( Adenosylhomocysteinase 89E CG8956-PC, isoform C ) or ( Adenosylhomocysteinase 89E CG8956-PD, isoform D ) or ( Adenosylhomocysteinase at 13 CG11654-PA )</html:p>
<html:p>SUBSYSTEM: methionine degradation I (to homocysteine)</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>PROTEIN_CLASS: 3.3.1.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADENOSINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__8__45__RXN" name="Glycerol-3-phosphate dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gpdh ) or ( Gpdh ) or ( CG31169 ) or ( CG3215 ) or ( Gpdh ) or ( CG31169 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glycerol 3 phosphate dehydrogenase CG9042-PC, isoform C ) or ( Glycerol 3 phosphate dehydrogenase CG9042-PB, isoform B ) or ( CG31169 CG31169-PA, isoform A ) or ( CG3215 CG3215-PA ) or ( Glycerol 3 phosphate dehydrogenase CG9042-PA, isoform A ) or ( CG31169 CG31169-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: glycerol-3-phosphate shuttle</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.8</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASNSYNB__45__RXN" name="asparagine synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG17486 ) or ( asparagine-synthetase )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG17486 CG17486-PA ) or ( CG33486-PA )</html:p>
<html:p>SUBSYSTEM: asparagine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.4</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLOSUCCINATE__45__SYNTHASE__45__RXN" name="adenylosuccinate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG17273 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG17273 CG17273-PA )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.4</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENYLOSUCC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOGLUCMUT__45__RXN" name="Phosphoglucomutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pgm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphogluconate mutase CG5165-PA )</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6182" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pgi ) or ( Pgi ) or ( Pgi )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoglucose isomerase CG8251-PA, isoform A ) or ( Phosphoglucose isomerase CG8251-PB, isoform B ) or ( Phosphoglucose isomerase CG8251-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALATE__45__DEH__45__RXN" name="Malate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG10748 ) or ( CG5362 ) or ( CG7998 ) or ( CG10749 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG10748 CG10748-PA ) or ( CG5362 CG5362-PA ) or ( CG7998 CG7998-PA ) or ( CG10749 CG10749-PA )</html:p>
<html:p>SUBSYSTEM: aspartate degradation II</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.37</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__5" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9629 ) or ( CG31075 ) or ( Aldh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9629 CG9629-PA ) or ( CG31075 CG31075-PA ) or ( Aldehyde dehydrogenase CG3752-PA )</html:p>
<html:p>SUBSYSTEM: dopamine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_34__45__DIHYDROXYPHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__782" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEXOKINASE__45__RXN" name="Hexokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hex-A ) or ( Hex-t1 ) or ( Hex-t2 ) or ( Hex-A ) or ( Hex-C )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Hexokinase A CG3001-PB, isoform B ) or ( Hex-t1 CG33102-PA ) or ( Hex-t2 CG32849-PA ) or ( Hexokinase A CG3001-PA, isoform A ) or ( Hexokinase C CG8094-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__Hexoses__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__HEXOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__821" name="Proline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( slgA ) or ( slgA ) or ( slgA ) or ( slgA ) or ( slgA ) or ( slgA ) or ( slgA ) or ( slgA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sluggish A CG1417-PE, isoform E ) or ( sluggish A CG1417-PA, isoform A ) or ( sluggish A CG1417-PH, isoform H ) or ( sluggish A CG1417-PG, isoform G ) or ( sluggish A CG1417-PF, isoform F ) or ( sluggish A CG1417-PD, isoform D ) or ( sluggish A CG1417-PB, isoform B ) or ( sluggish A CG1417-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: proline degradation I</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.8</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__9" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG16733 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG16733 CG16733-PA )</html:p>
<html:p>SUBSYSTEM: dopamine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.1</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>SIDE: PAP</html:p>
<html:p>SIDE: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7649" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__62__45__RXN" name="Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mipp2 ) or ( Mipp1 ) or ( Mipp1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Multiple inositol polyphosphate phosphatase 2 CG4317-PA ) or ( Multiple inositol polyphosphate phosphatase 1 CG4123-PB, isoform B ) or ( Multiple inositol polyphosphate phosphatase 1 CG4123-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.62</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__506" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNPOXI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG31473 ) or ( CG31472 ) or ( CG15343 ) or ( CG31472 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG31473 CG31473-PA ) or ( CG31472 CG31472-PB, isoform B ) or ( CG15343 CG15343-PA ) or ( CG31472 CG31472-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXINE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6283" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pug ) or ( pug ) or ( pug ) or ( pug )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pugilist CG4067-PD, isoform D ) or ( pugilist CG4067-PA, isoform A ) or ( pugilist CG4067-PC, isoform C ) or ( pugilist CG4067-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOMEVALONATE__45__KINASE__45__RXN" name="Phosphomevalonate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG10268 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG10268 CG10268-PA )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__499" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__641" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6282" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pug ) or ( pug ) or ( Nmdmc ) or ( Nmdmc ) or ( pug ) or ( pug )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pugilist CG4067-PD, isoform D ) or ( pugilist CG4067-PA, isoform A ) or ( NAD-dependent methylenetetrahydrofolate dehydrogenase CG18466-PB, isoform B ) or ( NAD-dependent methylenetetrahydrofolate dehydrogenase CG18466-PA, isoform A ) or ( pugilist CG4067-PC, isoform C ) or ( pugilist CG4067-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.9</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5727" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTDECARBOX__45__RXN" name="Glutamate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gad1 ) or ( b ) or ( Gad1 ) or ( Gad1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glutamic acid decarboxylase 1 CG14994-PA, isoform A ) or ( black CG7811-PA ) or ( Glutamic acid decarboxylase 1 CG14994-PC, isoform C ) or ( Glutamic acid decarboxylase 1 CG14994-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: glutamate dependent acid resistance</html:p>
<html:p>SUBSYSTEM: glutamate degradation IV</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.15</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRPPSYN__45__RXN" name="ribose-phosphate diphosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6767 ) or ( CG6767 ) or ( CG2246 ) or ( CG2246 ) or ( CG2246 ) or ( CG2246 ) or ( CG2246 ) or ( CG2246 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6767 CG6767-PA, isoform A ) or ( CG6767 CG6767-PB, isoform B ) or ( CG2246 CG2246-PB, isoform B ) or ( CG2246 CG2246-PD, isoform D ) or ( CG2246 CG2246-PC, isoform C ) or ( CG2246 CG2246-PA, isoform A ) or ( CG2246 CG2246-PE, isoform E ) or ( CG2246 CG2246-PF, isoform F )</html:p>
<html:p>SUBSYSTEM: PRPP biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.1</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALPHA__45__L__45__FUCOSIDASE__45__RXN" name="&amp;alpha;-L-fucosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6128 ) or ( CG6128 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6128-PB, isoform B ) or ( CG6128-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.51</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AN__45__ALPHA__45__L__45__FUCOSIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="L__45__FUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__15" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1998 ) or ( CG11162 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1998 CG1998-PA ) or ( CG11162 CG11162-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8610" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8611" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__16" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1998 ) or ( CG11162 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1998 CG1998-PA ) or ( CG11162 CG11162-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8611" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8612" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__17" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1998 ) or ( CG11162 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1998 CG1998-PA ) or ( CG11162 CG11162-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8612" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8613" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__16__45__RXN" name="Serine/threonine specific protein phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( tws ) or ( CG11597 ) or ( Pten ) or ( puc ) or ( tws ) or ( tws ) or ( tws ) or ( tws ) or ( tws ) or ( tws ) or ( tws ) or ( yrt ) or ( Pp1-87B ) or ( Ptp10D ) or ( Mipp1 ) or ( mts ) or ( Mkp ) or ( CanB ) or ( CG11597 ) or ( Mbs ) or ( flw ) or ( CG14411 ) or ( CG6746 ) or ( Ptp10D ) or ( Ptp10D ) or ( Mbs ) or ( Mbs ) or ( Mbs ) or ( CG14411 ) or ( flw ) or ( CanA1 ) or ( Pten ) or ( Pten ) or ( Pten ) or ( rdgC ) or ( Pten ) or ( Pten ) or ( rdgC ) or ( Mbs ) or ( CG6036 ) or ( CG9236 ) or ( MYPT-75D ) or ( rdgC ) or ( rdgC ) or ( Pdp ) or ( CG32812 ) or ( CG12252 ) or ( CG9267 ) or ( Mkp ) or ( Pp2B-14D ) or ( CanB2 ) or ( Mipp1 ) or ( Mbs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Protein phosphatase 2A at 85F ) or ( CG11597 CG11597-PA, isoform A ) or ( Pten CG5671-PF, isoform F ) or ( Velcro ) or ( Protein phosphatase 2A at 85F ) or ( Protein phosphatase 2A at 85F ) or ( Protein phosphatase 2A at 85F ) or ( Protein phosphatase 2A at 85F ) or ( Protein phosphatase 2A at 85F ) or ( Protein phosphatase 2A at 85F ) or ( Protein phosphatase 2A at 85F ) or ( dorsal holes B ) or ( Protein phosphatase 1 ) or ( Protein tyrosine phosphatase 10D CG1817-PB, isoform B ) or ( Multiple inositol polyphosphate phosphatase 1 CG4123-PB, isoform B ) or ( microtubule star CG7109-PA ) or ( CG34099-PA, isoform A ) or ( Calcineurin B CG4209-PA ) or ( CG11597 CG11597-PB, isoform B ) or ( Myosin binding subunit CG32156-PE, isoform E ) or ( flap wing CG2096-PB, isoform B ) or ( CG14411 CG14411-PB, isoform B ) or ( CG6746 CG6746-PA ) or ( Protein tyrosine phosphatase 10D CG1817-PD, isoform D ) or ( Protein tyrosine phosphatase 10D CG1817-PA, isoform A ) or ( Myosin binding subunit CG32156-PC, isoform C ) or ( Myosin binding subunit CG32156-PA, isoform A ) or ( Myosin binding subunit CG32156-PG, isoform G ) or ( CG14411 CG14411-PA, isoform A ) or ( flap wing CG2096-PA, isoform A ) or ( Calcineurin A1 CG1455-PA ) or ( Pten CG5671-PC, isoform C ) or ( Pten CG5671-PD, isoform D ) or ( Pten CG5671-PB, isoform B ) or ( retinal degeneration C CG6571-PA, isoform A ) or ( Pten CG5671-PE, isoform E ) or ( Pten CG5671-PA, isoform A ) or ( retinal degeneration C CG6571-PD, isoform D ) or ( Myosin binding subunit CG32156-PF, isoform F ) or ( CG6036 CG6036-PA ) or ( CG9236 CG9236-PA ) or ( MYPT-75D CG6896-PA ) or ( retinal degeneration C CG6571-PB, isoform B ) or ( retinal degeneration C CG6571-PC, isoform C ) or ( Pyruvate dehydrogenase phosphatase CG12151-PA ) or ( CG32812 CG32812-PA ) or ( CG12252 CG12252-PA ) or ( CG9267 CG9267-PA ) or ( CG34099-PB, isoform B ) or ( Protein phosphatase 2B at 14D CG9842-PA ) or ( Calcineurin B2 CG11217-PA ) or ( Multiple inositol polyphosphate phosphatase 1 CG4123-PA, isoform A ) or ( Myosin binding subunit CG32156-PH, isoform H )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.16</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOSIDE__45__TRIPHOSPHATASE__45__RXN" name="Nucleoside-triphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gnf1 ) or ( cutlet ) or ( CG3499 ) or ( NTPase ) or ( sick ) or ( sick ) or ( NTPase ) or ( rept ) or ( katanin-60 ) or ( CG11919 ) or ( NTPase ) or ( c12.2 ) or ( Orc5 ) or ( CG8798 ) or ( Srp54k ) or ( sick ) or ( CG9425 ) or ( Orc1 ) or ( CG8798 ) or ( Orc4 ) or ( Gnf1 ) or ( bor ) or ( CG9425 ) or ( CG5276 ) or ( CG13185 ) or ( Gtp-bp ) or ( CG13185 ) or ( Nsf2 ) or ( RfC3 ) or ( NTPase ) or ( CG8142 ) or ( pont ) or ( CG31453 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Germ line transcription factor 1 CG1119-PB, isoform B ) or ( cutlet CG33122-PA ) or ( CG3499 CG3499-PB ) or ( NTPase CG3059-PB, isoform B ) or ( CG34343-PD, isoform D ) or ( CG34343-PB, isoform B ) or ( NTPase CG3059-PA, isoform A ) or ( reptin CG9750-PA ) or ( katanin 60 CG10229-PA ) or ( CG11919 CG11919-PA, isoform A ) or ( NTPase CG3059-PD, isoform D ) or ( c12.2 CG12149-PA ) or ( Origin recognition complex subunit 5 CG7833-PA ) or ( CG8798 CG8798-PA, isoform A ) or ( Signal recognition particle protein 54k CG4659-PA ) or ( CG34343-PC, isoform C ) or ( CG9425 CG9425-PA, isoform A ) or ( Origin recognition complex subunit 1 CG10667-PA ) or ( CG8798 CG8798-PB, isoform B ) or ( Origin recognition complex subunit 4 CG2917-PA ) or ( Germ line transcription factor 1 CG1119-PA, isoform A ) or ( Cytoplasmic Protein 89BC ) or ( CG9425 CG9425-PB, isoform B ) or ( CG5276 CG5276-PA ) or ( CG13185 CG13185-PC, isoform C ) or ( GTP-binding protein CG2522-PA ) or ( CG13185 CG13185-PB, isoform B ) or ( NEM-sensitive fusion protein 2 CG33101-PA ) or ( RfC3 CG5313-PA ) or ( NTPase CG3059-PC, isoform C ) or ( CG8142 CG8142-PA ) or ( dPontin ) or ( CG31453 CG31453-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.15</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__SYN__45__GLUT__45__RXN" name="GMP synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bur )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( burgundy CG9242-PA )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.2</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__2" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7910 ) or ( CG5191 ) or ( CG8839 ) or ( gatA ) or ( CG5191 ) or ( CG5191 ) or ( CG8839 ) or ( CG5191 ) or ( CG5191 ) or ( PGRP-LB ) or ( PGRP-LB ) or ( CG5112 ) or ( CG8839 ) or ( CG7900 ) or ( CG8839 ) or ( PGRP-LB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7910 CG7910-PA ) or ( CG5191 CG5191-PD, isoform D ) or ( CG8839 CG8839-PC, isoform C ) or ( benedict ) or ( CG5191 CG5191-PC, isoform C ) or ( CG5191 CG5191-PA, isoform A ) or ( CG8839 CG8839-PD, isoform D ) or ( CG5191 CG5191-PB, isoform B ) or ( CG5191 CG5191-PE, isoform E ) or ( Peptidoglycan recognition protein LB CG14704-PB, isoform B ) or ( Peptidoglycan recognition protein LB CG14704-PA, isoform A ) or ( CG5112 CG5112-PA ) or ( CG8839 CG8839-PA, isoform A ) or ( CG7900 CG7900-PB ) or ( CG8839 CG8839-PE, isoform E ) or ( Peptidoglycan recognition protein LB CG14704-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: anandamide degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7598" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETHANOL__45__AMINE" stoichiometry="1"/>
      <speciesReference species="ARACHIDONIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FPPSYN__45__RXN" name="geranyltranstransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( qm ) or ( Fpps )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quemao CG8593-PA ) or ( Farnesyl pyrophosphate synthase CG12389-PA )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALIC__45__NADP__45__RXN" name="Malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Menl-1 ) or ( Menl-2 ) or ( Men ) or ( CG7848 ) or ( Menl-1 ) or ( Menl-2 ) or ( Mdh ) or ( Menl-2 ) or ( Menl-1 ) or ( Men )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Menl-1 CG7964-PA, isoform A ) or ( Menl-2 CG7969-PA, isoform A ) or ( Malic enzyme CG10120-PB, isoform B ) or ( CG7848 CG7848-PA ) or ( Menl-1 CG7964-PC, isoform C ) or ( CG7969-PC, isoform C ) or ( Malic DH ) or ( CG7969-PB, isoform B ) or ( Menl-1 CG7964-PB, isoform B ) or ( Malic enzyme CG10120-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.40</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETAGALACTOSID__45__RXN" name="&amp;beta;-galactosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gal ) or ( Ect3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta galactosidase CG9092-PA ) or ( Ect3 CG3132-PA )</html:p>
<html:p>SUBSYSTEM: lactose degradation III</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.23</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__4__46__10__45__RXN" name="Nucleoside-triphosphate--adenylate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Adk3 ) or ( Adk3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Adenylate kinase-3 CG6612-PB, isoform B ) or ( Adenylate kinase-3 CG6612-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.10</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nucleoside__45__Triphosphates__124__" stoichiometry="1"/>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleoside__45__Diphosphates__124__" stoichiometry="1"/>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__101__45__RXN" name="&amp;alpha;-1,3-mannosyl-glycoprotein &amp;beta;-1,2-N- acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mgat1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-GlcNAc:a-3-D-mannoside-beta-1, 2-N-acetylglucosaminyltransferase I CG13431-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.101</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__D__45__MANNOSYL__45__13__45__R1__45__BETA__45__D__45__MANNOSY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__12__45__ALPHA__45__D" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__HYDROXYPHENYLPYRUVATE__45__DIOXYGENASE__45__RXN" name="4-hydroxyphenylpyruvate dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG11796 ) or ( CG11796 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG11796 CG11796-PA, isoform A ) or ( CG11796 CG11796-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.27</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMOGENTISATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3341" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG15093 ) or ( CG15093 ) or ( Pgi ) or ( Pgi ) or ( Pgd ) or ( CG4747 ) or ( Pgi ) or ( CG15093 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG15093 CG15093-PA, isoform A ) or ( CG15093 CG15093-PB, isoform B ) or ( Phosphoglucose isomerase CG8251-PA, isoform A ) or ( Phosphoglucose isomerase CG8251-PB, isoform B ) or ( Phosphogluconate dehydrogenase CG3724-PA ) or ( CG4747 CG4747-PA ) or ( Phosphoglucose isomerase CG8251-PC, isoform C ) or ( CG15093 CG15093-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.44</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1122" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG8834 ) or ( CG4563 ) or ( CG8834 ) or ( CG9993 ) or ( CG11453 ) or ( CG5568 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG8834 CG8834-PB, isoform B ) or ( CG4563 CG4563-PA ) or ( CG8834 CG8834-PA, isoform A ) or ( CG9993 CG9993-PA ) or ( CG11453 CG11453-PA ) or ( CG5568 CG5568-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.12</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="_5__45__HYDROXY__45__FERULIC__45__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__HYDROXY__45__FERULOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LEUKOTRIENE__45__A4__45__HYDROLASE__45__RXN" name="Leukotriene-A4 hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG10602 ) or ( CG10602 ) or ( CG10602 ) or ( CG10602 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG10602 CG10602-PD, isoform D ) or ( CG10602 CG10602-PA, isoform A ) or ( CG10602 CG10602-PB, isoform B ) or ( CG10602 CG10602-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LEUKOTRIENE__45__A4" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_6Z8E10E14Z__45__5S12R__45__512__45__DIHYDROXYI" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6002" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III ) or ( Aldh-III )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aldehyde dehydrogenase type III CG11140-PD, isoform D ) or ( Aldehyde dehydrogenase type III CG11140-PA, isoform A ) or ( Aldehyde dehydrogenase type III CG11140-PH, isoform H ) or ( Aldehyde dehydrogenase type III CG11140-PE, isoform E ) or ( Aldehyde dehydrogenase type III CG11140-PC, isoform C ) or ( Aldehyde dehydrogenase type III CG11140-PI, isoform I ) or ( Aldehyde dehydrogenase type III CG11140-PB, isoform B ) or ( Aldehyde dehydrogenase type III CG11140-PG, isoform G ) or ( Aldehyde dehydrogenase type III CG11140-PF, isoform F )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.5</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5682" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R9__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6984 ) or ( CG6543 ) or ( CG8778 ) or ( CG6543 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6984 CG6984-PA ) or ( CG6543 CG6543-PA, isoform A ) or ( CG8778 CG8778-PA ) or ( CG6543 CG6543-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3742" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG2543 ) or ( CG31773 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2543 CG2543-PA ) or ( CG31773 CG31773-PA )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Folatepolyglutamate__45__n__124__" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Folatepolyglutamate__45__n__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9000" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt36Bc ) or ( Ext2 ) or ( Ext2 ) or ( Ugt86Di ) or ( Ugt86Dd ) or ( CG5724 ) or ( CG5999 ) or ( Ugt37b1 ) or ( GlcAT-P ) or ( ttv ) or ( GlcAT-S ) or ( GlcAT-P ) or ( CG15661 ) or ( Ugt86Dh ) or ( Ugt37c1 ) or ( GlcAT-P ) or ( Ugt86Dc ) or ( Act57B ) or ( GlcAT-S ) or ( CG3797 ) or ( GlcAT-I ) or ( CG17323 ) or ( Ugt58Fa ) or ( Ugt86De ) or ( Ugt86Dg ) or ( Act57B ) or ( Ugt36Bc ) or ( Ugt36Ba ) or ( CG11289 ) or ( CG6475 ) or ( Ugt36Bb ) or ( Ugt35b ) or ( CG4302 ) or ( CG31002 ) or ( Ugt35a ) or ( CG15661 ) or ( CG10178 ) or ( Ugt86Dj ) or ( Ugt86Da ) or ( CG9220 ) or ( Ugt37a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ugt36Bc CG17932-PB, isoform B ) or ( CG8433-PA, isoform A ) or ( CG8433-PB, isoform B ) or ( Ugt86Di CG6658-PA ) or ( Ugt86Dd CG6633-PB ) or ( CG5724 CG5724-PA ) or ( CG5999 CG5999-PA ) or ( UDP-glycosyltransferase 37b1 CG9481-PA ) or ( GlcAT-P CG6207-PC, isoform C ) or ( tout-velu CG10117-PA ) or ( GlcAT-S CG3881-PB, isoform B ) or ( GlcAT-P CG6207-PB, isoform B ) or ( CG15661 CG15661-PA, isoform A ) or ( Ugt86Dh CG4772-PA ) or ( UDP-glycosyltransferase 37c1 CG8652-PA ) or ( GlcAT-P CG6207-PA, isoform A ) or ( Ugt86Dc CG4739-PA ) or ( Actin 57B CG10067-PB, isoform B ) or ( GlcAT-S CG3881-PA, isoform A ) or ( CG3797 CG3797-PA ) or ( GlcAT-I CG32775-PA ) or ( CG17323 CG17323-PA ) or ( Ugt58Fa CG4414-PA ) or ( Ugt86De CG6653-PA ) or ( Ugt86Dg CG17200-PA ) or ( Actin 57B CG10067-PA, isoform A ) or ( Ugt36Bc CG17932-PA, isoform A ) or ( Ugt36Ba CG13270-PA ) or ( CG11289 CG11289-PA ) or ( CG6475 CG6475-PB ) or ( Ugt36Bb CG13271-PA ) or ( UDP-glycosyltransferase ) or ( CG4302 CG4302-PA ) or ( CG31002 CG31002-PA ) or ( UDP-glycosyltransferase 35a CG6644-PA ) or ( CG15661 CG15661-PB, isoform B ) or ( CG10178 CG10178-PA ) or ( Ugt86Dj CG15902-PA ) or ( Ugt86Da CG18578-PA ) or ( CG9220 CG9220-PC ) or ( UDP-glycosyltransferase 37a1 CG11012-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9459" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9460" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__20" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1998 ) or ( CG11162 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1998 CG1998-PA ) or ( CG11162 CG11162-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4184" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8617" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOACYLCOATHIOL__45__RXN" name="Acetyl-CoA C-acyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Thiolase ) or ( CG17597 ) or ( yip2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Thiolase CG4581-PA ) or ( CG17597 CG17597-PA ) or ( yippee interacting protein 2 CG4600-PA )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation II (core pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.16</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD_TO_NADH_COF_RXN" name="NAD_TO_NADH_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOKIN__45__RXN" name="Ribokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG13369 ) or ( CG17010 ) or ( CG17010 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG13369 CG13369-PA ) or ( CG17010 CG17010-PB, isoform B ) or ( CG17010 CG17010-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.15</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHENYLTHFCYCLOHYDRO__45__RXN" name="Methenyltetrahydrofolate cyclohydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pug ) or ( pug ) or ( Nmdmc ) or ( Nmdmc ) or ( pug ) or ( pug )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pugilist CG4067-PD, isoform D ) or ( pugilist CG4067-PA, isoform A ) or ( NAD-dependent methylenetetrahydrofolate dehydrogenase CG18466-PB, isoform B ) or ( NAD-dependent methylenetetrahydrofolate dehydrogenase CG18466-PA, isoform A ) or ( pugilist CG4067-PC, isoform C ) or ( pugilist CG4067-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation V (tetrahydrofolate pathway)</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_10__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__21" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1998 ) or ( CG11162 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1998 CG1998-PA ) or ( CG11162 CG11162-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8617" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8618" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__22" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1998 ) or ( CG11162 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1998 CG1998-PA ) or ( CG11162 CG11162-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8618" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8619" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3541" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5959 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5959 CG5959-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__318" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBOXYLESTERASE__45__RXN" name="Carboxylesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( alpha-Est2 ) or ( CG10175 ) or ( neuroligin ) or ( CG34127 ) or ( CG6018 ) or ( alpha-Est7 ) or ( CG9289 ) or ( clt ) or ( alpha-Est9 ) or ( alpha-Est1 ) or ( Gli ) or ( alpha-Est3 ) or ( alpha-Est5 ) or ( CG4757 ) or ( alpha-Est6 ) or ( alpha-Est4 ) or ( Jhedup ) or ( CG34139 ) or ( CG3635 ) or ( CG3841 ) or ( CG7529 ) or ( CG10339 ) or ( alpha-Est8 ) or ( CG12869 ) or ( Est-P ) or ( CG6414 ) or ( Gli ) or ( Gli ) or ( alpha-Est9 ) or ( CG4382 ) or ( alpha-Est10 ) or ( CG31146 ) or ( Gli ) or ( Gli ) or ( CG10175 ) or ( alpha-Est7 ) or ( CG10175 ) or ( CG9287 ) or ( Est-6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-Esterase-2 CG2505-PA ) or ( CG10175 CG10175-PC, isoform C ) or ( neuroligin CG13772-PA ) or ( CG34127 CG34127-PA ) or ( CG6018 CG6018-PA ) or ( Aliesterase ) or ( CG9289 CG9289-PA ) or ( cricklet CG9858-PA ) or ( alpha-Esterase-9 CG1128-PA, isoform A ) or ( alpha-Esterase-1 CG1031-PA ) or ( Gliotactin CG3903-PB, isoform B ) or ( alpha-Esterase-3 CG1257-PA ) or ( alpha-Esterase-5 CG1089-PA ) or ( CG4757 CG4757-PA ) or ( alpha-Esterase-6 CG1108-PA ) or ( alpha-Esterase-4 CG1082-PA ) or ( Juvenile hormone esterase duplication CG8424-PA ) or ( CG34139 CG34139-PA ) or ( CG3635 CG3635-PA ) or ( CG3841 CG3841-PA ) or ( CG7529 CG7529-PA ) or ( CG10339 CG10339-PA ) or ( alpha-Esterase-8 CG1121-PA ) or ( CG12869 CG12869-PA ) or ( Esterase P CG17148-PA ) or ( CG6414 CG6414-PA ) or ( Gliotactin CG3903-PC, isoform C ) or ( Gliotactin CG3903-PA, isoform A ) or ( alpha-Esterase-9 CG1128-PB, isoform B ) or ( CG4382 CG4382-PA ) or ( alpha-Esterase-10 CG1131-PA ) or ( CG31146 CG31146-PD ) or ( Gliotactin CG3903-PE, isoform E ) or ( Gliotactin CG3903-PD, isoform D ) or ( CG10175 CG10175-PA, isoform A ) or ( Aliesterase ) or ( CG10175 CG10175-PB, isoform B ) or ( CG9287 CG9287-PA ) or ( Esterase 6 CG6917-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Carboxylic__45__esters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ESTRADIOL__45__17__45__BETA__45__DEHYDROGENASE__45__RXN" name="Estradiol 17 &amp;beta;-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( scu ) or ( CG11151 ) or ( CG3415 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( scully CG7113-PA ) or ( CG11151 CG11151-PA ) or ( CG3415 CG3415-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.62</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__352" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ESTRONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__68__45__RXN" name="1-phosphatidylinositol-4-phosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PIP5K59B ) or ( CG6355 ) or ( CG17471 ) or ( sktl ) or ( PIP5K59B ) or ( CG6355 ) or ( CG17471 ) or ( PIP5K59B )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PIP5K59B CG3682-PA, isoform A ) or ( CG6355-PB, isoform B ) or ( CG17471 CG17471-PB, isoform B ) or ( skittles CG9985-PA ) or ( PIP5K59B CG3682-PB, isoform B ) or ( CG6355-PA, isoform A ) or ( CG17471 CG17471-PA, isoform A ) or ( PIP5K59B CG3682-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.68</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1108" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OXALYL__45__COA__45__DECARBOXYLASE__45__RXN" name="Oxalyl-CoA decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG11208 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG11208 CG11208-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2PGADEHYDRAT__45__RXN" name="Phosphopyruvate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Eno ) or ( Eno ) or ( Eno ) or ( Eno ) or ( Eno )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Enolase CG17654-PB, isoform B ) or ( Enolase CG17654-PA, isoform A ) or ( Enolase CG17654-PE, isoform E ) or ( Enolase CG17654-PC, isoform C ) or ( Enolase CG17654-PD, isoform D )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__149__45__RXN" name="N-acetyllactosaminide &amp;beta;-1,3-N-acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG11149 ) or ( CG3253 ) or ( CG15483 ) or ( CG11149 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG11149 CG11149-PA, isoform A ) or ( CG3253 CG3253-PA ) or ( CG15483 CG15483-PA ) or ( CG11149 CG11149-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.149</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINYL__45__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__13__45__ETCETERA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__7__45__RXN" name="Kynurenine--oxoglutarate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6950 ) or ( CG6950 ) or ( CG6950 ) or ( CG6950 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6950 CG6950-PD, isoform D ) or ( CG6950 CG6950-PB, isoform B ) or ( CG6950 CG6950-PC, isoform C ) or ( CG6950 CG6950-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.7</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__476" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1TRANSKETO__45__RXN" name="Transketolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5103 ) or ( CG8036 ) or ( CG8036 ) or ( CG8036 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5103 CG5103-PA ) or ( CG8036 CG8036-PD, isoform D ) or ( CG8036 CG8036-PB, isoform B ) or ( CG8036 CG8036-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__IDITOL__45__2__45__DEHYDROGENASE__45__RXN" name="L-iditol 2-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG4836 ) or ( Sodh-2 ) or ( Sodh-1 ) or ( CG4836 ) or ( CG4836 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG4836 CG4836-PA, isoform A ) or ( Sorbitol dehydrogenase-2 CG4649-PA ) or ( Sorbitol dehydrogenase 1 CG1982-PA ) or ( CG4836 CG4836-PB, isoform B ) or ( CG4836 CG4836-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.14</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__369" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SORBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYISOBUTYRYL__45__COA__45__HYDROLASE__45__RXN" name="3-hydroxyisobutyryl-CoA hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG5044 ) or ( CG5044 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG5044 CG5044-PA, isoform A ) or ( CG5044 CG5044-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTEIN__45__TYROSINE__45__PHOSPHATASE__45__RXN" name="Protein-tyrosine-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ptp69D ) or ( eya ) or ( l(1)G0232 ) or ( Ptpmeg ) or ( l(1)G0232 ) or ( l(1)G0232 ) or ( Pten ) or ( puc ) or ( l(1)G0232 ) or ( Ptpmeg ) or ( Ptpmeg ) or ( ia2 ) or ( l(1)G0232 ) or ( Ptp10D ) or ( CG31469 ) or ( Ptp4E ) or ( PTP-ER ) or ( Ptpmeg ) or ( CG14714 ) or ( eya ) or ( EDTP ) or ( Ptp61F ) or ( CG7180 ) or ( Ptp10D ) or ( Pez ) or ( Ptp10D ) or ( primo-2 ) or ( csw ) or ( csw ) or ( ssh ) or ( csw ) or ( primo-1 ) or ( PRL-1 ) or ( Lar ) or ( Lar ) or ( l(1)G0232 ) or ( Ptp4E ) or ( Ptp69D ) or ( EDTP ) or ( Ptp99A ) or ( CG14714 ) or ( Pten ) or ( Pten ) or ( Pten ) or ( Pten ) or ( CG14714 ) or ( Pten ) or ( primo-1 ) or ( primo-1 ) or ( primo-2 ) or ( Ptp61F ) or ( ssh ) or ( twe ) or ( Ptp52F ) or ( CG9311 ) or ( Ptp61F ) or ( Ptp61F ) or ( CG14297 ) or ( dome ) or ( cdc14 ) or ( stg ) or ( Ptp99A ) or ( Ptp99A ) or ( Ptp99A ) or ( PRL-1 ) or ( ia2 ) or ( Ptp99A )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Protein tyrosine phosphatase 69D CG10975-PB, isoform B ) or ( eyes absent CG9554-PB, isoform B ) or ( lethal (1) G0232 CG32697-PF, isoform F ) or ( Ptpmeg CG1228-PB, isoform B ) or ( lethal (1) G0232 CG32697-PB, isoform B ) or ( lethal (1) G0232 CG32697-PA, isoform A ) or ( Pten CG5671-PF, isoform F ) or ( Velcro ) or ( lethal (1) G0232 CG32697-PC, isoform C ) or ( Ptpmeg CG1228-PD, isoform D ) or ( Ptpmeg CG1228-PC, isoform C ) or ( ia2 CG31795-PB, isoform B ) or ( lethal (1) G0232 CG32697-PD, isoform D ) or ( Protein tyrosine phosphatase 10D CG1817-PB, isoform B ) or ( CG31469 CG31469-PA ) or ( Protein tyrosine phosphatase 4E CG6899-PA, isoform A ) or ( Protein tyrosine phosphatase-ERK/Enhancer of Ras1 CG9856-PA ) or ( Ptpmeg CG1228-PA, isoform A ) or ( CG14714 CG14714-PA, isoform A ) or ( eyes absent CG9554-PA, isoform A ) or ( Egg-derived tyrosine phosphatase CG6542-PA, isoform A ) or ( Protein tyrosine phosphatase 61F CG9181-PD, isoform D ) or ( CG7180 CG7180-PA ) or ( Protein tyrosine phosphatase 10D CG1817-PD, isoform D ) or ( Pez CG9493-PA ) or ( Protein tyrosine phosphatase 10D CG1817-PA, isoform A ) or ( CG33747-PC, isoform C ) or ( corkscrew CG3954-PC, isoform C ) or ( corkscrew CG3954-PB, isoform B ) or ( MAP-kinase-phosphatase ) or ( corkscrew CG3954-PA, isoform A ) or ( CG33748-PC, isoform C ) or ( PRL-1 CG4993-PA, isoform A ) or ( Leukocyte-antigen-related-like CG10443-PB, isoform B ) or ( Leukocyte-antigen-related-like CG10443-PA, isoform A ) or ( lethal (1) G0232 CG32697-PE, isoform E ) or ( Protein tyrosine phosphatase 4E CG6899-PB, isoform B ) or ( Protein tyrosine phosphatase 69D CG10975-PA, isoform A ) or ( Egg-derived tyrosine phosphatase CG6542-PB, isoform B ) or ( Protein tyrosine phosphatase 99A CG11516-PD, isoform D ) or ( CG14714 CG14714-PB, isoform B ) or ( Pten CG5671-PC, isoform C ) or ( Pten CG5671-PD, isoform D ) or ( Pten CG5671-PB, isoform B ) or ( Pten CG5671-PE, isoform E ) or ( CG14714 CG14714-PC, isoform C ) or ( Pten CG5671-PA, isoform A ) or ( CG33748-PA, isoform A ) or ( CG33748-PB, isoform B ) or ( CG33747-PB, isoform B ) or ( Protein tyrosine phosphatase 61F CG9181-PA, isoform A ) or ( MAP-kinase-phosphatase ) or ( twine CG4965-PA ) or ( Ptp52F CG18243-PA ) or ( CG9311 CG9311-PA ) or ( Protein tyrosine phosphatase 61F CG9181-PC, isoform C ) or ( Protein tyrosine phosphatase 61F CG9181-PB, isoform B ) or ( CG14297 CG14297-PA ) or ( domeless CG14226-PA ) or ( cdc14 CG7134-PA ) or ( String/Cdc25 phosphatase ) or ( Protein tyrosine phosphatase 99A CG11516-PC, isoform C ) or ( Protein tyrosine phosphatase 99A CG11516-PB, isoform B ) or ( Protein tyrosine phosphatase 99A CG11516-PE, isoform E ) or ( PRL-1 CG4993-PB, isoform B ) or ( ia2 CG31795-PA, isoform A ) or ( Protein tyrosine phosphatase 99A CG2005-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.48</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__tyrosine__45__phosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Tyrosines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHASERSYN__45__RXN" name="CDP-diacylglycerol--serine O-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG4825 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG4825 CG4825-PA )</html:p>
<html:p>SUBSYSTEM: phosphatidyl-ethanolamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.8</html:p>
<html:p>SIDE: SER</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__SERINE" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BIOPTERIN_TO_TETRA__45__H__45__BIOPTERIN_COF_RXN" name="BIOPTERIN_TO_TETRA-H-BIOPTERIN_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="BIOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALONYL__45__COA_TO_CO__45__A_COF_RXN" name="MALONYL-COA_TO_CO-A_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__88__45__RXN" name="Peptide deformylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG31278 ) or ( CG31373 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG31278 CG31278-PA ) or ( CG31373 CG31373-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.88</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__L__45__METHIONYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="METHIONYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMIDINESYN__45__RXN" name="Spermidine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG4300 ) or ( CG4300 ) or ( SpdS ) or ( SpdS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG4300 CG4300-PA, isoform A ) or ( CG4300 CG4300-PB, isoform B ) or ( Spermidine Synthase CG8327-PB, isoform B ) or ( Spermidine Synthase CG8327-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: spermidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNDECARBOX__45__RXN" name="Ornithine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Odc1 ) or ( Odc2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ornithine decarboxylase 1 CG8721-PA ) or ( Ornithine decarboxylase 2 CG8719-PA )</html:p>
<html:p>SUBSYSTEM: putrescine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.17</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__KIN__45__RXN" name="Glycerol kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7995 ) or ( CG7995 ) or ( CG8298 ) or ( Gyk ) or ( CG7995 ) or ( CG8298 ) or ( CG1271 ) or ( CG1271 ) or ( CG1271 ) or ( CG1271 ) or ( mri ) or ( mri ) or ( Gyk ) or ( CG7995 ) or ( mri ) or ( CG7995 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7995 CG7995-PB, isoform B ) or ( CG7995 CG7995-PD, isoform D ) or ( CG8298 CG8298-PA, isoform A ) or ( Glycerol kinase CG18374-PB, isoform B ) or ( CG7995 CG7995-PA, isoform A ) or ( CG8298 CG8298-PB, isoform B ) or ( CG1271 CG1271-PA, isoform A ) or ( CG1271 CG1271-PC, isoform C ) or ( CG1271 CG1271-PD, isoform D ) or ( CG1271 CG1271-PB, isoform B ) or ( mrityu CG1216-PB, isoform B ) or ( mrityu CG1216-PC, isoform C ) or ( Glycerol kinase CG18374-PA, isoform A ) or ( CG7995 CG7995-PC, isoform C ) or ( mrityu CG1216-PA, isoform A ) or ( CG7995 CG7995-PE, isoform E )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.30</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URKI__45__RXN" name="Uridine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( l(2)k01209 ) or ( CG6364 ) or ( l(2)k01209 ) or ( Adk1 ) or ( Adk1 ) or ( l(2)k01209 ) or ( l(2)k01209 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lethal (2) k01209 CG4798-PA, isoform A ) or ( CG6364 CG6364-PA ) or ( lethal (2) k01209 CG4798-PB, isoform B ) or ( Adenylate kinase-1 CG17146-PB, isoform B ) or ( Adenylate kinase-1 CG17146-PA, isoform A ) or ( lethal (2) k01209 CG4798-PD, isoform D ) or ( lethal (2) k01209 CG4798-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.48</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANSENOYLCOARED__45__RXN" name="Trans-2-enoyl-CoA reductase (NADPH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG16935 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG16935 CG16935-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.38</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__60__45__RXN" name="Protein geranylgeranyltransferase type II" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( l(1)G0144 ) or ( CG17565 ) or ( CG12007 ) or ( Rep )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lethal (1) G0144 CG3073-PA ) or ( CG17565 CG17565-PA ) or ( CG12007 CG12007-PA ) or ( Rab escort protein CG8432-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.60</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="2"/>
      <speciesReference species="PROT__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__GERANYLGERANYL__45__PROTEIN" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__27__45__RXN" name="Methylmalonate-semialdehyde dehydrogenase (acylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG17896 ) or ( CG17896 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG17896 CG17896-PA, isoform A ) or ( CG17896 CG17896-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.27</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>COFACTOR: PROPIONYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CH3__45__MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6271" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1998 ) or ( CG11162 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1998 CG1998-PA ) or ( CG11162 CG11162-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5847" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5845" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__83__45__RXN" name="Dolichyl-phosphate &amp;beta;-D-mannosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG10166 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG10166 CG10166-PA )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.83</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__XYLULOSE__45__REDUCTASE__45__RXN" name="D-xylulose reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sodh-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Sorbitol dehydrogenase 1 CG1982-PA )</html:p>
<html:p>SUBSYSTEM: xylitol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.9</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PMPOXI__45__RXN" name="Pyridoxamine-phosphate oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG31473 ) or ( CG31472 ) or ( CG15343 ) or ( CG31472 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG31473 CG31473-PA ) or ( CG31472 CG31472-PB, isoform B ) or ( CG15343 CG15343-PA ) or ( CG31472 CG31472-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCORN__45__AMINOTRANSFERASE__45__RXN" name="Ornithine--oxo-acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Oat ) or ( CG8745 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ornithine aminotransferase precursor CG8782-PA ) or ( CG8745 CG8745-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.13</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N2__45__SUCCINYLORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__822" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__UREIDOPROPIONASE__45__RXN" name="&amp;beta;-ureidopropionase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pyd3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyd3 CG3027-PA )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.6</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__UREIDO__45__PROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OCTANOL__45__DEHYDROGENASE__45__RXN" name="Octanol dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Fdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Formaldehyde dehydrogenase CG6598-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.73</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OCTANOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__371" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__43__45__RXN" name="Phosphatidylcholine--sterol O-acyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG18858 ) or ( CG31683 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG18858 CG18858-PA ) or ( CG31683 CG31683-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.43</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sterols__124__" stoichiometry="1"/>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Steryl__45__Esters__124__" stoichiometry="1"/>
      <speciesReference species="__124__1__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALLANTOINASE__45__RXN" name="Allantoinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG6106 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG6106 CG6106-PA )</html:p>
<html:p>SUBSYSTEM: allantoin degradation to ureidoglycolate I (urea producing)</html:p>
<html:p>SUBSYSTEM: allantoin degradation to ureidoglycolate II (ammonia producing)</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ALLANTOIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALLANTOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8988" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Scs-fp ) or ( CG6255 ) or ( Sucb ) or ( Scsalpha ) or ( Sucb ) or ( Scs-fp ) or ( Scs-fp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Succinyl coenzyme A synthetase flavoprotein subunit CG17246-PA, isoform A ) or ( CG6255 CG6255-PA ) or ( Sucb CG10622-PB, isoform B ) or ( Succinyl coenzyme A synthetase alpha subunit CG1065-PA ) or ( Sucb CG10622-PA, isoform A ) or ( Succinyl coenzyme A synthetase flavoprotein subunit CG17246-PC, isoform C ) or ( Succinyl coenzyme A synthetase flavoprotein subunit CG17246-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: itaconate degradation</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.4</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ITACONATE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1137" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__15__45__RXN" name="Cholinephosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cct1 ) or ( Cct1 ) or ( Cct1 ) or ( Cct2 ) or ( Cct1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CTP:phosphocholine cytidylyltransferase 1 CG1049-PB, isoform B ) or ( CTP:phosphocholine cytidylyltransferase 1 CG1049-PD, isoform D ) or ( CTP:phosphocholine cytidylyltransferase 1 CG1049-PC, isoform C ) or ( CTP:phosphocholine cytidylyltransferase 2 CG18330-PA ) or ( CTP:phosphocholine cytidylyltransferase 1 CG1049-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis</html:p>
<html:p>SUBSYSTEM: choline biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.15</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP__45__CHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSAMINE__45__6__45__P__45__DEAMIN__45__RXN" name="Glucosamine-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Oscillin ) or ( Oscillin )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Oscillin CG6957-PB, isoform B ) or ( Oscillin CG6957-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: N-acetylglucosamine degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.99.6</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__13__45__RXN" name="Mannose-1-phosphate guanylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1129 ) or ( CG1129 ) or ( CG8207 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1129 CG1129-PA, isoform A ) or ( CG1129 CG1129-PB, isoform B ) or ( CG8207 CG8207-PA )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.13</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
      <speciesReference species="MANNOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4941" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG10082 ) or ( CG10082 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG10082 CG10082-PB, isoform B ) or ( CG10082 CG10082-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1107" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIPHOSPHO__45__1D__45__MYO__45__INOSITOL__45__TETRAKISPHOSPH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__153__45__RXN" name="Phosphatidylinositol-4,5-bisphosphate 3-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pi3K92E ) or ( Pi3K92E )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PI 3-kinase ) or ( PI 3-kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.153</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHATIDYLINOSITOL__45__345__45__TRIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYRIBONUCSYN__45__RXN" name="Phosphoribosylamine--glycine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ade3 ) or ( ade3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenosine 3 CG31628-PA, isoform A ) or ( adenosine 3 CG31628-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__P__45__BETA__45__D__45__RIBOSYL__45__AMINE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDPDIGLYSYN__45__RXN" name="phosphatidate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CdsA ) or ( CG8311 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CDP diglyceride synthetase CG7962-PA ) or ( CG8311 CG8311-PA )</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis II</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis I (plastid)</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.41</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ECDYSONE__45__OXIDASE__45__RXN" name="Ecdysone oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Eo )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ecdysone oxidase CG9504-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ECDYSONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__331" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFATE__45__ADENYLYLTRANS__45__RXN" name="Sulfate adenylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Paps ) or ( Paps ) or ( Paps ) or ( Paps ) or ( Paps ) or ( Paps )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PAPS synthetase CG8363-PD, isoform D ) or ( PAPS synthetase CG8363-PE, isoform E ) or ( PAPS synthetase CG8363-PA, isoform A ) or ( PAPS synthetase CG8363-PF, isoform F ) or ( PAPS synthetase CG8363-PB, isoform B ) or ( PAPS synthetase CG8363-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: sulfate activation for sulfonation</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.4</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="APS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLCOADEHYDROG__45__RXN" name="Acyl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Arc42 ) or ( CG4860 ) or ( CG5009 ) or ( Acox57D-d ) or ( Acox57D-p ) or ( CG4586 ) or ( CG17544 ) or ( CG12262 ) or ( CG17544 ) or ( CG9527 ) or ( CG17544 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Arc42 CG4703-PA ) or ( CG4860 CG4860-PA ) or ( CG5009 CG5009-PA ) or ( acyl-Coenzyme A oxidase at 57D distal CG9709-PA ) or ( acyl-Coenzyme A oxidase at 57D proximal CG9707-PA ) or ( CG4586 CG4586-PA ) or ( CG17544 CG17544-PC, isoform C ) or ( CG12262 CG12262-PA ) or ( CG17544 CG17544-PB, isoform B ) or ( CG9527 CG9527-PA ) or ( CG17544 CG17544-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.3</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6269" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1998 ) or ( CG11162 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1998 CG1998-PA ) or ( CG11162 CG11162-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5845" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5846" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBONYL__45__REDUCTASE__45__NADPH__45__RXN" name="Carbonyl reductase (NADPH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( antdh ) or ( CG11200 ) or ( CG11200 ) or ( sni )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( antdh CG1386-PA ) or ( CG11200 CG11200-PA, isoform A ) or ( CG11200 CG11200-PB, isoform B ) or ( sniffer CG10964-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.184</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LONG__45__CHAIN__45__KETONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STRICTOSIDINE__45__SYNTHASE__45__RXN" name="Strictosidine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ssl2 ) or ( Hmu )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Strictosidine synthase-like 2 CG11833-PA ) or ( Hemomucin CG3373-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.3.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRYPTAMINE" stoichiometry="1"/>
      <speciesReference species="SECOLOGANIN__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="STRICTOSIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__34__45__RXN" name="6,7-dihydropteridine reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dhpr ) or ( Dhpr ) or ( Dhpr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dihydropteridine reductase CG4665-PB, isoform B ) or ( Dihydropteridine reductase CG4665-PC, isoform C ) or ( Dihydropteridine reductase CG4665-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.34</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5678__45__TETRAHYDROPTERIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_67__45__DIHYDROPTERIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINOPARATHION__45__PHOSPHATASE__45__RXN" name="Aryldialkylphosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG18473 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG18473 CG18473-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__PARATHION" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIETHYLTHIOPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__259" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUMHYDR__45__RXN" name="Fumarate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( l(1)G0255 ) or ( CG31874 ) or ( CG6140 ) or ( CG4095 ) or ( l(1)G0255 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lethal (1) G0255 CG4094-PB, isoform B ) or ( CG31874 CG31874-PA ) or ( CG6140 CG6140-PA ) or ( CG4095 CG4095-PA ) or ( lethal (1) G0255 CG4094-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STEROL__45__O__45__ACYLTRANSFERASE__45__RXN" name="Sterol O-acyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mdy ) or ( CG5397 ) or ( mdy ) or ( mdy ) or ( mdy ) or ( CG8112 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( midway CG31991-PB, isoform B ) or ( CG5397 CG5397-PA ) or ( midway CG31991-PA, isoform A ) or ( midway CG31991-PD, isoform D ) or ( midway CG31991-PC, isoform C ) or ( CG8112 CG8112-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.26</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Cholesterol__45__esters__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AROMATIC__45__L__45__AMINO__45__ACID__45__DECARBOXYLASE__45__RXN" name="Aromatic-L-amino-acid decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tdc1 ) or ( Ddc ) or ( amd ) or ( Tdc2 ) or ( amd ) or ( Ddc ) or ( Ddc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Tyrosine decarboxylase 1 CG30445-PA ) or ( Dopa decarboxylase CG10697-PB, isoform B ) or ( alpha methyl dopa-resistant CG10501-PA, isoform A ) or ( Tyrosine decarboxylase 2 CG30446-PA ) or ( alpha methyl dopa-resistant CG10501-PB, isoform B ) or ( Dopa decarboxylase CG10697-PC, isoform C ) or ( Dopa decarboxylase CG10697-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: beta-carboline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.28</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRYPTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYMALTOPHOSPHORYL__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GlyP ) or ( CG16965 ) or ( GlyP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glycogen phosphorylase CG7254-PA, isoform A ) or ( CG16965 CG16965-PA ) or ( Glycogen phosphorylase CG7254-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CMPKI__45__RXN" name="Cytidylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dak1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dak1 CG6092-PA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHAGLYPSYN__45__RXN" name="CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7718 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7718 CG7718-PA )</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis I (plastid)</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.5</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL__45__P" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPTIDYLPROLYL__45__ISOMERASE__45__RXN" name="Peptidylprolyl isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Cypl ) or ( ninaA ) or ( CG10907 ) or ( CG3511 ) or ( FK506-bp1 ) or ( Fkbp13 ) or ( dod ) or ( Moca-cyp ) or ( Fkbp13 ) or ( CG11777 ) or ( Cyp1 ) or ( CG17266 ) or ( CG2852 ) or ( FKBP59 ) or ( CG2852 ) or ( CG14715 ) or ( CG7768 ) or ( CG7768 ) or ( CG7747 ) or ( CG5071 ) or ( cyp33 ) or ( FK506-bp2 ) or ( CG5482 ) or ( CG5071 ) or ( Moca-cyp ) or ( CG11858 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cyclophilin-like CG13892-PA ) or ( neither inactivation nor afterpotential A CG3966-PA ) or ( CG10907 CG10907-PA ) or ( CG3511 CG3511-PA ) or ( FK506-binding protein 1 CG6226-PA ) or ( Fkbp13 CG9847-PB, isoform B ) or ( dodo CG17051-PA ) or ( Moca-cyp CG1866-PB, isoform B ) or ( Fkbp13 CG9847-PA, isoform A ) or ( CG11777 CG11777-PA ) or ( Cyclophilin 1 CG9916-PA ) or ( CG17266 CG17266-PA ) or ( CG2852 CG2852-PB, isoform B ) or ( FK506-binding protein FKBP59 CG4535-PA ) or ( CG2852 CG2852-PA, isoform A ) or ( CG14715 CG14715-PA ) or ( CG7768 CG7768-PB, isoform B ) or ( CG7768 CG7768-PA, isoform A ) or ( CG7747 CG7747-PA ) or ( CG5071 CG5071-PA, isoform A ) or ( cyclophilin-33 CG4886-PA ) or ( FK506-binding protein 2 CG11001-PA ) or ( CG5482 CG5482-PA ) or ( CG5071 CG5071-PB, isoform B ) or ( Moca-cyp CG1866-PA, isoform A ) or ( CG11858 CG11858-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.2.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8624" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8625" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CMP__45__N__45__ACETYL__45__NEURAMINATE_TO_CMP_COF_RXN" name="CMP-N-ACETYL-NEURAMINATE_TO_CMP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CMP__45__N__45__ACETYL__45__NEURAMINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AIRS__45__RXN" name="phosphoribosylformylglycinamidine cyclo-ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ade3 ) or ( ade3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenosine 3 CG31628-PA, isoform A ) or ( adenosine 3 CG31628-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROPRIBTRANS__45__RXN" name="Orotate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( r-l )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UMP synthase )</html:p>
<html:p>SUBSYSTEM: uridine-5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OROTATE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTIDINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYL__45__COA_TO_CO__45__A_COF_RXN" name="ACYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__99__46__5__45__RXN" name="3-oxo-5-&amp;alpha;-steroid 4-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7840 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7840 CG7840-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.5</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__3__45__Oxo__45__5__45__Alpha__45__Steroids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__3__45__Oxo__45__Delta__45__4__45__Steroids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TYROSINE__45__AMINOTRANSFERASE__45__RXN" name="Tyrosine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1461 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1461 CG1461-PA )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>SUBSYSTEM: 4-hydroxyphenylpyruvate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.5</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_SUC__45__COA_COF_RXN" name="CO-A_TO_SUC-COA_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUC1PURIDYLTRANS__45__RXN" name="UTP--glucose-1-phosphate uridylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( UGP ) or ( UGP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UGP CG4347-PC, isoform C ) or ( UGP CG4347-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis II (from UDP-D-Glucose)</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.9</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__14__45__RXN" name="Ethanolamine-phosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pect ) or ( Pect ) or ( Pect ) or ( Pect )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoethanolamine cytidylyltransferase CG5547-PC, isoform C ) or ( Phosphoethanolamine cytidylyltransferase CG5547-PD, isoform D ) or ( Phosphoethanolamine cytidylyltransferase CG5547-PB, isoform B ) or ( Phosphoethanolamine cytidylyltransferase CG5547-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: phosphatidylethanolamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.14</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FOLYLPOLYGLUTAMATESYNTH__45__RXN" name="folylpolyglutamate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG2543 ) or ( CG31773 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2543 CG2543-PA ) or ( CG31773 CG31773-PA )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYMETHYLGLUTARYL__45__COA__45__LYASE__45__RXN" name="Hydroxymethylglutaryl-CoA lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG10399 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG10399 CG10399-PA )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.4</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__43____45__ADP__45__RIBOSYLTRANSFERASE__45__RXN" name="NAD(+) ADP-ribosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( tankyrase )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tankyrase CG4719-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.30</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__ADP__45__D__45__Ribosyl__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="__40__ADP__45__D__45__RIBOSYL__41____40__N__41____45__ACCEPTOR" stoichiometry="1"/>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__ADP__45__D__45__Ribosyl__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="__40__ADP__45__D__45__RIBOSYL__41____40__N__43__1__41____45__ACCEPTOR" stoichiometry="1"/>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDLIPOXN__45__RXN" name="Dihydrolipoamide dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG7430 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG7430 CG7430-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROLIPOAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPOAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERLEU__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG1673 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG1673 CG1673-PA )</html:p>
<html:p>SUBSYSTEM: leucine degradation III</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LEU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__4CH3__45__PENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1024" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CG2767 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG2767 CG2767-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Primary__45__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONOSYLTRANSFERASE__45__RXN" name="UDP-glucuronosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt36Bc ) or ( Ext2 ) or ( Ext2 ) or ( Ugt86Di ) or ( Ugt86Dd ) or ( CG5724 ) or ( CG5999 ) or ( Ugt37b1 ) or ( GlcAT-P ) or ( ttv ) or ( GlcAT-S ) or ( GlcAT-P ) or ( CG15661 ) or ( Ugt86Dh ) or ( Ugt37c1 ) or ( GlcAT-P ) or ( Ugt86Dc ) or ( Act57B ) or ( GlcAT-S ) or ( CG3797 ) or ( GlcAT-I ) or ( CG17323 ) or ( Ugt58Fa ) or ( Ugt86De ) or ( Ugt86Dg ) or ( Act57B ) or ( Ugt36Bc ) or ( Ugt36Ba ) or ( CG11289 ) or ( CG6475 ) or ( Ugt36Bb ) or ( Ugt35b ) or ( CG4302 ) or ( CG31002 ) or ( Ugt35a ) or ( CG15661 ) or ( CG10178 ) or ( Ugt86Dj ) or ( Ugt86Da ) or ( CG9220 ) or ( Ugt37a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ugt36Bc CG17932-PB, isoform B ) or ( CG8433-PA, isoform A ) or ( CG8433-PB, isoform B ) or ( Ugt86Di CG6658-PA ) or ( Ugt86Dd CG6633-PB ) or ( CG5724 CG5724-PA ) or ( CG5999 CG5999-PA ) or ( UDP-glycosyltransferase 37b1 CG9481-PA ) or ( GlcAT-P CG6207-PC, isoform C ) or ( tout-velu CG10117-PA ) or ( GlcAT-S CG3881-PB, isoform B ) or ( GlcAT-P CG6207-PB, isoform B ) or ( CG15661 CG15661-PA, isoform A ) or ( Ugt86Dh CG4772-PA ) or ( UDP-glycosyltransferase 37c1 CG8652-PA ) or ( GlcAT-P CG6207-PA, isoform A ) or ( Ugt86Dc CG4739-PA ) or ( Actin 57B CG10067-PB, isoform B ) or ( GlcAT-S CG3881-PA, isoform A ) or ( CG3797 CG3797-PA ) or ( GlcAT-I CG32775-PA ) or ( CG17323 CG17323-PA ) or ( Ugt58Fa CG4414-PA ) or ( Ugt86De CG6653-PA ) or ( Ugt86Dg CG17200-PA ) or ( Actin 57B CG10067-PA, isoform A ) or ( Ugt36Bc CG17932-PA, isoform A ) or ( Ugt36Ba CG13270-PA ) or ( CG11289 CG11289-PA ) or ( CG6475 CG6475-PB ) or ( Ugt36Bb CG13271-PA ) or ( UDP-glycosyltransferase ) or ( CG4302 CG4302-PA ) or ( CG31002 CG31002-PA ) or ( UDP-glycosyltransferase 35a CG6644-PA ) or ( CG15661 CG15661-PB, isoform B ) or ( CG10178 CG10178-PA ) or ( Ugt86Dj CG15902-PA ) or ( Ugt86Da CG18578-PA ) or ( CG9220 CG9220-PC ) or ( UDP-glycosyltransferase 37a1 CG11012-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Acceptor__124__" stoichiometry="1"/>
      <speciesReference species="__124__Non__45__Glucur__45__Glucuronoside__45__Acceptors__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Beta__45__D__45__Glucuronides__124__" stoichiometry="1"/>
      <speciesReference species="__124__Glucuronosylated__45__Glucuronoside__45__Acceptors__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2962" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Formaldehyde dehydrogenase CG6598-PA )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation II (glutathione-dependent)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.284</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__HYDROXYMETHYLGLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__548" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOCYSTEINE__45__S__45__METHYLTRANSFERASE__45__RXN" name="Homocysteine S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG10623 ) or ( CG10621 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG10623 CG10623-PA ) or ( CG10621 CG10621-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.10</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GART__45__RXN" name="Phosphoribosylglycinamide formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ade3 ) or ( ade3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenosine 3 CG31628-PA, isoform A ) or ( adenosine 3 CG31628-PB, isoform B )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.2</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>COFACTOR: _10__45__FORMYL__45__THF</html:p>
<html:p>SIDE: THF</html:p>
<html:p>SIDE: _10__45__FORMYL__45__THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3443" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CG9629 ) or ( CG31075 ) or ( Aldh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CG9629 CG9629-PA ) or ( CG31075 CG31075-PA ) or ( Aldehyde dehydrogenase CG3752-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TESTOSTERONE__45__17__45__BETA__45__DEHYDROGENASE__45__RXN" name="Testosterone 17-&amp;beta;-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( scu )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( scully CG7113-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.63</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TESTOSTERONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ANDROST4ENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3701" name="Protein geranylgeranyltransferase type I" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( betaggt-II ) or ( betaggt-I )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta subunit of type II geranylgeranyl transferase CG18627-PA ) or ( beta subunit of type I geranylgeranyl transferase CG3469-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.59</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROT__45__CYS" stoichiometry="1"/>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__GERANYLGERANYL__45__PROTEIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SAMDECARB__45__RXN" name="Adenosylmethionine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SamDC ) or ( SamDC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-adenosylmethionine decarboxylase CG5029-PB, isoform B ) or ( S-adenosylmethionine decarboxylase CG5029-PA, isoform A )</html:p>
<html:p>SUBSYSTEM: spermidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.50</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OXIDIZED__45__DITHIOTHREITOL_TO_DITHIOTHREITOL_COF_RXN" name="OXIDIZED-DITHIOTHREITOL_TO_DITHIOTHREITOL_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="OXIDIZED__45__DITHIOTHREITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DITHIOTHREITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__8__45__RXN" name="Dimethylaniline monooxygenase (N-oxide forming)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Fmo-2 ) or ( Fmo-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Flavin-containing monooxygenase 2 CG3174-PA ) or ( Flavin-containing monooxygenase 1 CG3006-PA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.8</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NN__45__DIMETHYLANILINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NN__45__DIMETHYLANILINE__45__N__45__OXIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GAPOXNPHOSPHN__45__RXN" name="Glyceraldehyde 3-phosphate dehydrogenase (phosphorylating)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ca-alpha1T ) or ( CG13492 ) or ( CG9010 ) or ( oxt ) or ( Gapdh1 ) or ( Gapdh1 ) or ( DDB1 ) or ( Gapdh2 ) or ( Nup133 ) or ( CG9467 ) or ( Gapdh2 ) or ( CG13492 ) or ( Ca-alpha1T )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ca-alpha1T CG15899-PB, isoform B ) or ( CG13492 CG13492-PA, isoform A ) or ( CG9010 CG9010-PA ) or ( peptide O-xylosyltransferase CG32300-PB ) or ( Glyceraldehyde 3 phosphate dehydrogenase 1 CG12055-PA, isoform A ) or ( Glyceraldehyde 3 phosphate dehydrogenase 1 CG12055-PB, isoform B ) or ( DDB1 CG7769-PA ) or ( Glyceraldehyde 3 phosphate dehydrogenase 2 CG8893-PB, isoform B ) or ( CG6958 CG6958-PA ) or ( CG9467 CG9467-PA ) or ( Glyceraldehyde 3 phosphate dehydrogenase 2 CG8893-PA, isoform A ) or ( CG13492 CG13492-PB, isoform B ) or ( Ca-alpha1T CG15899-PC, isoform C )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FAD_TO_FADH2_COF_RXN" name="FAD_TO_FADH2_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="FAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FADH2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2961" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation II (glutathione-dependent)</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.22</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__HYDROXYMETHYLGLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
</listOfReactions>
</model>
</sbml>
